Mapping quantitative trait loci affecting feather pecking behavior and stress response in laying hens

Buitenhuis, A.J.; Rodenburg, T.B.; Hierden, Y.M. van; Siwek, Maria; Cornelissen, S.J.B.; Nieuwland, M.G.B.; Crooijmans, R.P.M.A.; Groenen, M.A.M.; Koene, P.; Korte, S. Mechiel; Bovenhuis, H.; Poel, J.J. van der

doi:10.1093/ps/82.8.1215

Cited by 89 publications

(44 citation statements)

References 34 publications

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“…Parent-of-origin effects have also been reported for QTL affecting the stress response and immune response . These two latter studies have been reported to be incorrect due to data handling error (Buitenhuis et al, 2006), but the parentof-origin effects have not yet been reanalyzed (van der Poel, personal communication).…”

Section: Qtl With Parent-of-origin Effectsmentioning

confidence: 99%

Parent-of-origin specific QTL – a possibility towards understanding reciprocal effects in chicken and the origin of imprinting

Tuiskula-Haavisto¹,

Vilkki²

2007

Cytogenet Genome Res

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Reciprocal effects for sexual maturity, egg production, egg quality traits and viability are well known in poultry crosses. They have been used in an optimal way to form profitable production hybrids. These effects have been hypothesized to originate from sex-linked genes, maternal effects or a combination of both. However, these may not be the only explanations for reciprocal effects. Recent mapping of quantitative trait loci (QTL) has revealed autosomal areas with parent-of-origin specific effects in the chicken. In mammals, parental imprinting, i.e. the specifically regulated expression of either maternal or paternal allele in the offspring, is the main cause of such effects. The most commonly accepted hypothesis for the origin of imprinting, the conflict hypothesis, assumes a genetic conflict of interest between the maternal and paternal genomes regarding the allocation of resources to the offspring. It also intrinsically implies that imprinting should not occur in oviparous taxa. However, new molecular genetic information has raised a need to review the possible involvement of imprinting or some related phenomena as a putative cause of reciprocal effects in poultry. Comparative mapping provides strong evidence for the conservation of orthologous imprinted gene clusters on chicken macrochromosomes. Furthermore, these gene clusters exhibit asynchronous DNA replication, an epigenetic mark specific for all imprinted regions. It has been proposed that these intrinsic chromosomal properties have been important for the evolution of imprinted gene expression in the mammalian lineage. Many of the mapped parent-of-origin specific QTL effects in chicken locate in or close to these conserved regions that show some of the basic features involved in monoallelic expression. If monoallelic expression in these regions would be observed in birds, the actual mechanism and cause may be different from the imprinting that evolved later in the mammalian lineage. In this review we discuss recent molecular genetic results that may provide tools for understanding of reciprocal differences in poultry breeding and the evolution of imprinting.

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Section: Qtl With Parent-of-origin Effectsmentioning

confidence: 99%

Parent-of-origin specific QTL – a possibility towards understanding reciprocal effects in chicken and the origin of imprinting

Tuiskula-Haavisto¹,

Vilkki²

2007

Cytogenet Genome Res

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“…Four microsatellite markers have been located within the chicken MHC-B region, LEI0258, MCW0371, MCW0312 and MHC-D (Buitenhuis et al, 2003;Crooijmans et al, 1997;Fulton et al, 2006;McConnell et al, 1999;Sironi et al, 2011), which can be effectively used to determine MHC-B haplotypes. Especially, LEI0258 marker genotypes could provide good indications of MHC-B haplotypes and can be used for preliminary screening in chicken populations (Chazara et al, 2013(Chazara et al, , 2011Fulton et al, 2006;Nikbakht et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Establishment of six homozygous MHC-B haplotype populations associated with susceptibility to Marek’s disease in Chinese specific pathogen-free BWEL chickens

Gao¹,

Han²,

Han³

et al. 2015

Infection, Genetics and Evolution

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“…QTLs for basal corticosterone (Cort) levels have also been identified (20,25,27). However, only three studies, each in a different species, have investigated QTL for Cort in response to stress (9,13,29), and to date, no QTL studies have been done investigating adrenal gland weight and its relationship to stress.…”

mentioning

confidence: 99%

Genetic analysis of the stress-responsive adrenocortical axis

Solberg

Baum

Ahmadiyeh

et al. 2006

Physiological Genomics

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The underlying genetic components contributing to individual variability in functions of the stress-responsive hypothalamic-pituitary-adrenal (HPA) axis are poorly understood. To determine genetic loci mediating three aspects of the adrenocortical function, we conducted a quantitative trait locus (QTL) analysis in the segregating F2 generation of a Wistar Kyoto (WKY) ϫ Fischer 344 (F344) cross, two inbred rat strains that differ in several HPA axis measures. The following three components of adrenocortical function are known to be regulated by different mechanisms that are mediated via suprahypothalamic, hypothalamic, pituitary, and intra-adrenal influences: basal plasma corticosterone (Cort) levels, plasma Cort response to a 10-min restraint stress, and adrenal weight. Genome scans identified a complex genetic architecture for the basal Cort phenotype, including sex and maternal lineage effects. Pairwise interactions were also identified for this trait. We identified three significant and two suggestive QTLs for stress Cort, along with two pairs of interacting loci for this trait. Four highly significant and two suggestive loci were identified for adrenal weight, with no interacting loci. In contrast to basal Cort, no sex-or lineagedependent QTL were identified for stress Cort or adrenal weight, despite the large sex differences in these phenotypes. We identified three nucleotide alterations in an obvious candidate gene mapped to the most significant QTL for stress Cort, Cort-binding globulin (CBG), one of which is known to alter CBG binding. This analysis confirms that three separate traits regulated by the HPA axis are controlled by multiple, but mainly nonoverlapping, QTLs.hypothalamic-pituitary-adrenal axis; corticosterone; quantitative trait loci analysis; Wistar Kyoto rat GENES INVOLVED IN individual variation of hypothalamic-pituitary-adrenal (HPA) axis activity, particularly in regard to disease-causing aspects of chronic stress, are unknown. While acute activation of the HPA axis during stress, "a state of threatened homeostasis," leads to a cascade of physiological and behavioral adaptive responses that increase survival of an organism (e.g., increased arousal, increased respiratory rate, and decreased appetite), chronic stress, which results in constant high levels of circulating glucocorticoids, can lead to pathophysiologies such as depression, diabetes, cardiovascular disease, and hypertension (10). There is a high degree of individual variation in response to both acute and chronic stress, and some individuals will not develop any of the abovementioned diseases when exposed to chronic stress. Family and twin studies have demonstrated that individual variation of HPA axis activity is regulated, at least in part, by genetics (e.g., Refs. 4, 16). Identification of the underlying genetic components, however, is difficult, because HPA axis function is so dependent on the environment.Although molecular techniques have been used to study the stress response (for a review, see Ref. 37), very little is kno...

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Mapping quantitative trait loci affecting feather pecking behavior and stress response in laying hens

Cited by 89 publications

References 34 publications

Parent-of-origin specific QTL – a possibility towards understanding reciprocal effects in chicken and the origin of imprinting

Parent-of-origin specific QTL – a possibility towards understanding reciprocal effects in chicken and the origin of imprinting

Establishment of six homozygous MHC-B haplotype populations associated with susceptibility to Marek’s disease in Chinese specific pathogen-free BWEL chickens

Genetic analysis of the stress-responsive adrenocortical axis

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