Nowadays, people are paying greater attention to the concept of childcare, and the healthy development of children is humanity’s hope for the future. The newborn stage is the most critical stage of a child’s development, and learning and mastering neonatal care is the first important lesson for parents. To meet the needs of today’s learners and to break the traditional teaching model, this paper develops a set of interactive newborn nursing knowledge system that composes the content of trivial nursing knowledge, reconstructs the knowledge structure system, and provides new teaching methods such as text browsing, 3D animation presentation, picture presentation, video presentation, interactive games, and tests for newborns. Text browsing, 3D animation, image demonstration, video demonstration, and interactive games and tests, among other new teaching methods, give a new teaching mode and method for neonatal nursing education. The study included 158 infants from local hospital. The study was divided into two groups, each with 80 cases: a control group (conventional care) and a study group (quality care management). The outcomes were contrasted and compared. The results revealed that the study group had a lower incidence of nursing defects than the control group, and the difference was statistically significant (
P
0.05
); the study group had a lower incidence of diseases than the control group, and the difference was statistically significant (
P
<
0.05
). The study goes over the complete process of incorporating the instructional display into the interactive newborn care knowledge system. Multimedia techniques and applications were researched throughout the design and production process in order to blend intrinsic knowledge material with digital technology to produce new educational ideas.