Mapping Standard Automated Perimetry to the Peripapillary Retinal Nerve Fiber Layer in Glaucoma

Ferreras, Antonio; Pablo, L.; Garway-Heath, David F.; Fogagnolo, Paolo; García‐Feijoó, Julián

doi:10.1167/iovs.08-1775

Cited by 127 publications

(124 citation statements)

References 56 publications

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“…Moreover, conversion to glaucoma was defined by objective changes measured by HRT, which is a validated technology for diagnosing and monitoring ONH changes in patients with glaucoma or at risk for developing the disease. 19,[24][25][26]28,29 Our long follow-up period allowed us to obtain enough MRA converters to provide reliable results, especially because the glaucomatous ONH changes usually occur slowly and progressively in this kind of patient.…”

Section: Discussionmentioning

confidence: 99%

“…The temporal and nasal sectors of HRT3 were excluded from the statistical analysis because the superior and inferior sectors of the optic disc are the most sensitive for the detection of early glaucomatous changes. 19,[23][24][25][26][27][28][29] Thus, the sample was divided into two groups: subjects who converted to glaucoma (MRA-converters), which included participants with worsening in at least three MRA sectors during the follow-up period, [30][31][32] and subjects who did not convert to glaucoma (nonconverters), comprised of participants who did not meet the previous condition.…”

Section: Follow-up and Definition Of Study Endpointsmentioning

confidence: 99%

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Predictive Value of Retrobulbar Blood Flow Velocities in Glaucoma Suspects

Calvo

Ferreras

Polo

et al. 2012

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. To determine whether retrobulbar blood flow (RBF) velocities are predictive of conversion to glaucoma. METHODS.A total of 262 glaucoma suspects were prospectively selected. Participants had normal visual field, increased intraocular pressure, and glaucomatous optic disc appearance at baseline. Topographic analysis of the optic nerve head was performed using a confocal laser scanning ophthalmoscope and the blood flow velocity of retrobulbar vessels was measured by color Doppler imaging. Conversion to glaucoma was assessed according to the changes in the color-coded Moorfields Regression Analysis (MRA) classification of the confocal laser scanning system during a 48-month follow-up period. Survival curves and hazard ratios (HRs) for the association between RBF parameters and conversion to glaucoma were calculated.RESULTS. End-diastolic velocity and mean velocity in the ophthalmic artery were reduced in subjects that converted to glaucoma based on MRA (36 individuals, 13.7%), while resistivity (RI) and pulsatility indices were increased in the same vessel. Patients with RI values lower than 0.75 in the ophthalmic artery had a survival rate (MRA-converters versus nonconverters) of 93.9%, whereas individuals with RI values greater than 0.75 had a survival rate of 81.7% (HR ¼ 3.306; P ¼ 0.002).CONCLUSIONS. Abnormal RBF velocities measured by color Doppler ultrasound may be a risk factor for conversion to glaucoma. An RI value higher than 0.75 in the ophthalmic artery was associated with the development of glaucoma.

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Section: Discussionmentioning

confidence: 99%

Section: Follow-up and Definition Of Study Endpointsmentioning

confidence: 99%

Predictive Value of Retrobulbar Blood Flow Velocities in Glaucoma Suspects

Calvo

Ferreras

Polo

et al. 2012

Invest. Ophthalmol. Vis. Sci.

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“…This likely suggests that fibers loss and VF defects do not show an exact correlation maybe due to the necessity for a minimum expected fiber loss before VF loss occurs, as already stated in previous studies. 16 …”

Section: Discussionmentioning

confidence: 99%

Evaluation of retinal nerve fiber layer and ganglion cell complex thickness after ocular blunt trauma

Cennamo

Forte

Reibaldi

et al. 2013

Eye

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Purpose To evaluate circumpapillary retinal nerve fiber layer (cpRNFL) and ganglion cell complex (GCC) after ocular blunt trauma. Methods Best-corrected visual acuity (BCVA), cpRNFL and GCC were evaluated by RTVue-100 OCT in all consecutive patients with previous monocular blunt trauma seen between January 2012 and December 2012. Results Twenty-two patients (11 females, 11 males, mean age 43.9±14.2 years) were included in the study. Patients were seen after a mean of 8.42 ± 13.3 (range, 0.08-55.3) years from ocular blunt trauma. BCVA was normal in 11 cases and was less than 0.4 LogMAR in all cases. In 9/22 patients (40.9%), cpRNFL and GCC were reduced, whereas in one case an isolated reduction of GCC with normal cpRNFL was present. In patients with reduction of cpRNFL and GCC, mean BCVA was 0.17 ± 0.17 LogMAR. In 6/9 patients (66.6%) with cpRNFL and GCC reduction, BCVA was r0.1 LogMAR. Conclusion cpRNFL and GCC reduction may be present after ocular blunt trauma and may be associated with preserved visual acuity.

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“…[11][12][13][14][15][16][17][18][19][20] Some studies compared tests for evaluating the VF based on other stimuli than white-on-white perimetry, [21][22][23][24][25][26][27] or evaluated the structure-function relationship. [28][29][30][31][32][33] The objective of the present study was to evaluate and compare the glaucoma diagnostic accuracy of the most widely used VF testing algorithms in clinical practice (24-2 SITA Standard strategy of HFA and G1 TOP strategy of Octopus) with one of the most advanced structural imagining tests (OCT). To the best of our knowledge, this is the first study aimed at comparing the diagnostic accuracy of these tests.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic ability of Humphrey perimetry, Octopus perimetry, and optical coherence tomography for glaucomatous optic neuropathy

Monsalve

Ferreras

Calvo

et al. 2016

Eye

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Purpose To evaluate and compare the diagnostic accuracy of the Humphrey Field Analyzer (HFA), Octopus perimetry, and Cirrus OCT for glaucomatous optic neuropathy. Methods Eighty-eight healthy individuals and 150 open-angle glaucoma patients were consecutive and prospectively selected. Eligibility criteria for the glaucoma group were intraocular pressure ≥ 21 mm Hg and glaucomatous optic nerve head morphology. All subjects underwent a reliable standard automated perimetry with the HFA and Octopus perimeter, and were imaged with the Cirrus OCT. Receiver-operating characteristic (ROC) curves were plotted for the threshold values and main indices of the HFA and Octopus, the peripapillary retinal nerve fiber layer thicknesses, and the optic nerve head parameters. Sensitivities at 85 and 95% fixedspecificities were also calculated. The best areas under the ROC curves (AUCs) were compared using the DeLong method. Results In the glaucoma group, mean deviation (MD) was − 5.42 ± 4.6 dB for HFA and 3.90 ± 3.6 dB for Octopus. The MD of the HFA (0.966; Po0.001), mean sensitivity of the Octopus (0.941; Po0.001), and average cup-todisc (C/D) ratio measured by the Cirrus OCT (0.958; Po0.001) had the largest AUCs for each test studied. There were no significant differences among them. Sensitivities at 95% fixed-specificity were 82% for pattern standard deviation of the HFA, 81.3% for average C/D ratio of OCT, and 80% for the MD of the Octopus. Conclusions HFA, Octopus, and Cirrus OCT demonstrated similar diagnostic accuracies for glaucomatous optic neuropathy. Visual field and OCT provide supplementary information and thus these tests are not interchangeable.

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Mapping Standard Automated Perimetry to the Peripapillary Retinal Nerve Fiber Layer in Glaucoma

Cited by 127 publications

References 56 publications

Predictive Value of Retrobulbar Blood Flow Velocities in Glaucoma Suspects

Predictive Value of Retrobulbar Blood Flow Velocities in Glaucoma Suspects

Evaluation of retinal nerve fiber layer and ganglion cell complex thickness after ocular blunt trauma

Diagnostic ability of Humphrey perimetry, Octopus perimetry, and optical coherence tomography for glaucomatous optic neuropathy

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