This research is focused on the evaluation of the reliability of regional landslide susceptibility models obtained by exploiting inhomogeneous (for quality, resolution and/or triggering related type and intensity) collected inventories for calibration. At a large-scale glance, merging more inventories can result in well-performing models hiding potential strong predictive deficiencies. An example of the limits that such kinds of models can display is given by a landslide susceptibility study, which was carried out for a large sector of the coastal area of El Salvador, where an apparently well-performing regional model (AUC = 0.87) was obtained by regressing a dataset through multivariate adaptive regression splines (MARS), including five landslide inventories from volcanic areas (Ilopango and Coatepeque caldera; San Salvador, San Miguel, and San Vicente Volcanoes). A multiscale validation strategy was applied to verify its actual predictive skill on a local base, bringing to light the loss in the predictive power of the regional model, with a lowering of AUC (20% on average) and strong effects in terms of sensitivity and specificity.