Mapping Synaptic Connectivity in the Cerebellar Cortex Using RuBi-Glutamate Uncaging

Spaeth, Ludovic; Gagneux, Theo; Dorgans, Kevin; Valera, Antoine M.; Sugihara, Izumi; Isope, Philippe

doi:10.1007/978-1-0716-2026-7_9

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Interrogating the Spatial Organization Of The Gc-pc Connection1

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2022

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“…Uncaged glutamate excites mostly dendritic or somatic receptors preventing the direct excitation of neighboring axons as opposed to electrical or optogenetic stimulation. When glutamate uncaging is combined with a system enabling specific and localized restricted illumination (laser scanning or patterned light illumination), the spatial organization of the presynaptic cells as well as their synaptic weights on the target cell can be reconstructed [23,24,52,53] (Fig. 1A, B).…”

Section: Interrogating the Spatial Organization Of The Gc-pc Connectionmentioning

confidence: 99%

What Can We Learn from Synaptic Connectivity Maps about Cerebellar Internal Models?

Spaeth

Isope

2022

Cerebellum

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The cerebellum is classically associated with fine motor control, motor learning, and timing of actions. However, while its anatomy is well described and many synaptic plasticity have been identified, the computation performed by the cerebellar cortex is still debated. We, here, review recent advances on how the description of the functional synaptic connectivity between granule cells and Purkinje cells support the hypothesis that the cerebellum stores internal models of the body coordinates. We propose that internal models are specific of the task and of the locomotor context of each individual.

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Section: Interrogating the Spatial Organization Of The Gc-pc Connectionmentioning

confidence: 99%

What Can We Learn from Synaptic Connectivity Maps about Cerebellar Internal Models?

Spaeth

Isope

2022

Cerebellum

Self Cite

View full text Add to dashboard Cite

show abstract

Mapping Synaptic Connectivity in the Cerebellar Cortex Using RuBi-Glutamate Uncaging

Cited by 1 publication

References 62 publications

What Can We Learn from Synaptic Connectivity Maps about Cerebellar Internal Models?

What Can We Learn from Synaptic Connectivity Maps about Cerebellar Internal Models?

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