Mapping the cancer-specific QLQ-C30 onto the generic EQ-5D-5L and SF-6D in colorectal cancer patients

Ameri, Hosein; Yousefi, Mahmood; Yaseri, Mehdi; Nahvijou, Azin; Arab, Mohammad; Sari, Ali Akbari

doi:10.1080/14737167.2018.1517046

Cited by 36 publications

(31 citation statements)

References 33 publications

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“…20 The CLAD model is another alternative that estimates coefficients based on median. 21 Nevertheless, the CLAD is not appropriate because the most econometric models are based on the mean, and some evidence shows that it performed poorly in studies that had used the EQ-5D instrument as the dependent variable. 22,23 One of the efforts to overcome these problems is using the estimators based on the beta distribution.…”

Section: Discussionmentioning

confidence: 99%

Health-related quality of life and its associated factors in patients with type 2 diabetes mellitus

et al. 2020

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Background: Assessing the health-related quality of life in patients with type 2 diabetes mellitus is important for evaluation of treatment outcome. The purpose of this study was to evaluate the health-related quality of life in type 2 diabetes mellitus patients and its related factors in Yazd. Methods: Data were gathered by using the EuroQoL-five-dimension-5 level instrument as well as using medical records of 734 outpatients with type 2 diabetes mellitus who were referred to the largest governmental diabetes center in South of Iran, Yazd province. When appropriate, the Kruskal–Wallis test or the Wilcoxon test was used to test the difference in the health-related quality-of-life scores in each factor. Finally, the adjusted limited dependent variable mixture model was developed to investigate factors associated with health-related quality-of-life scores. Results: The mean and median of the EuroQoL-five-dimension-5 level index values of 717 patients who completed the questionnaires were 0.75 ± 0.006 and 0.72 ± 0.20, respectively, and those of the Visual Analogue Scale scores were 69.25 ± 0.63 and 75 ± 30, respectively. The mean scores for health-related quality of life were significantly higher for employed, educated, single, and male patients, as well as patients without comorbidities, diabetes-related complications, and hemoglobin A1c level >7%. Adjusted limited dependent variable mixture model showed that gender, age, marital status, and diabetes-related complications are significant independent predictors of EuroQoL-five-dimension-5 level index value. Conclusion: The mean scores for health-related quality of life in patients with type 2 diabetes mellitus were moderate in this study, and this finding is consistent with health-related quality-of-life scores reported in other studies conducted in the Middle East region. Therefore, health-related quality of life should be the most important consideration in the management of patients. In parallel, some factors, especially gender, should be considered to improve health-related quality of life.

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Section: Discussionmentioning

confidence: 99%

Health-related quality of life and its associated factors in patients with type 2 diabetes mellitus

et al. 2020

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“…14 Utility values obtained from the Euro QoL EQ-5D-5L Persian version. 15 Patients asked about their current condition and their condition during states. The utility data of HD, PD, and TX patients, was 0.72 and 0.75, and 0.82 respectively.…”

Section: Research Methods and Patients Descriptionsmentioning

confidence: 99%

Economic evaluation of End Stage Renal Disease treatments in Iran

Moradpour

Hadian

Tavakkoli

2020

Clinical Epidemiology and Global Health

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Background: End-stage Renal Disease is considered a health problem due to the high prevalence and economic burden on society and the health system. This study utilizes a cost-utility analysis to evaluate the costs and outcomes of the Iranian End Stage Renal Disease patients. Methods: A Markov model-based economic evaluation with a societal perspective, and a lifetime horizon performed to quantify the costs and health-related outcomes in terms of QALY. Direct medical costs obtained from hospital billing and medical records and direct non-medical costs, and indirect costs derived from interviews with patients. Three policy options, the hemodialysis, peritoneal dialysis and kidney transplantation were compared. Most of the Transplants from deceased and rest were from Live Related Donors. One-way and probabilistic sensitivity analyses were performed to study uncertainty. Results: Annual average cost of hemodialysis is $13477 cost of peritoneal dialysis is $12865, and cost of Transplantation is $16450.The Transplantation arm gained 9.43 QALY compared with peritoneal dialysis and hemodialysis with 6.95 and 6.04 QALY respectively. When Transplantation was compared with peritoneal dialysis, Incremental Cost-Effectiveness Ratio was $1744 per QALY. ICER value suggests that Transplantation is cost-effective compared with peritoneal dialysis at a willingness-to-pay threshold of $12,400, and hemodialysis was dominated. Conclusion: This study suggests that kidney transplantation is a better option over hemodialysis and peritoneal dialysis. We conclude that serious efforts ought to be made to foster potential brain-dead donors and altruistic kidney donation and promote peritoneal dialysis as a superior alternative to hemodialysis for eligible patients.

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“…Among them, numerical algorithms have been developed to map disease-specific questionnaires to the EuroQol Group Five-Dimensional (EQ-5D), a standardized instrument for measuring generic health status, values in cancer groups. [11][12][13][14] The EQ-5D is one of the most commonly used instruments to describe and assess HRQoL based on public preference; it has two versions: the 3 level (3L) and 5 level (5L). 15 A study using a sizeable multinational dataset showed that, compared with the 3L, the 5L is more accurate and preferred regarding both study results and participant responses.…”

Section: Introductionmentioning

confidence: 99%

<p>Measurement of Health-Related Quality of Life Among Colorectal Cancer Patients Using the Vietnamese Value Set of the EQ-5D-5L</p>

Tran

Pham

Nguyen

et al. 2020

PPA

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Health-related quality of life (HRQoL) is an important construct in clinical settings, and it is crucial that it should be properly measured. As the EuroQol-5-dimensions-5 levels (EQ-5D-5L) is more effective for such measurement than the 3-level model, data on economic models, clinical studies, and public health evaluations previously collected through the EQ-5D-3L need to be revaluated using the EQ-5D-5L. This study evaluated colorectal cancer (CRC) patients' HRQoL scores using the Vietnamese EQ-5D-5L value set. Patients and Methods: The cross-sectional study included CRC patients treated at a tertiary public hospital. HRQoL was assessed using the EQ-5D-5L, and HRQoL utility scores were calculated using the Vietnamese value set. Tobit regression examined factors associated with HRQoL. Results: The analysis included 197 CRC patients. Ages ranged from 20 to 87 years (M = 57.64, SD = 13.5); 42.2% and 57.8% were diagnosed with cancer of the colon or rectum/ anus, respectively. Mean EQ-5D-5L was 0.561 (range, −0.5115 to 1). Most participants experienced anxiety/depression (88%), followed by pain/discomfort (87%), mobility (71%), usual activity (69%), and self-care (67%). Advanced CRC stage (stage II: β −0.303, se 0.08; stage III: β −0.305, se 0.07; stage IV: β −0.456, se 0.07) and surgery (β −0.113, se 0.05) were negatively associated with EQ-5D-5L scores. Advanced education (high school: β 0.273, se 0.07); college/vocational: β 0.134se 0.05; university/higher: Coef 0.213, se 0.08;) and older age (age group 35−44: β 0.253, se 0.10; 45−54: β 0.327, se 0.09; 55−64: β 0.355 se 0.09; 65+ β 0.204, se 0.09) were positively associated with EQ-5D-5L scores. Conclusion: Patients in advanced CRC stages or undergoing surgery experienced lower HRQoL and higher prevalence of anxiety/depression and pain/discomfort. Older age and high educational attainment predicted high HRQoL. This study provides information on CRC patients' health utility based on various patient characteristics, which can be used in future economic evaluations.

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Mapping the cancer-specific QLQ-C30 onto the generic EQ-5D-5L and SF-6D in colorectal cancer patients

Abstract: Our results demonstrated that algorithms developed based on OLS Models 1 and 2 are the best for predicted EQ-5D-5L and SF-6D values respectively.

Cited by 36 publications

References 33 publications

Health-related quality of life and its associated factors in patients with type 2 diabetes mellitus

Health-related quality of life and its associated factors in patients with type 2 diabetes mellitus

Economic evaluation of End Stage Renal Disease treatments in Iran

<p>Measurement of Health-Related Quality of Life Among Colorectal Cancer Patients Using the Vietnamese Value Set of the EQ-5D-5L</p>

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