1989
DOI: 10.1056/nejm198905253202102
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Mapping the Gene for Hereditary Cutaneous Malignant Melanoma–Dysplastic Nevus to Chromosome Lp

Abstract: We used molecular genetic techniques and multipoint linkage analyses to locate the gene responsible for cutaneous malignant melanoma-dysplastic nevus. We evaluated 99 relatives and 26 spouses in six families with a predisposition to melanoma. Thirty-four family members had cutaneous malignant melanoma, and 31 of these 34 also had histologically confirmed dysplastic nevi. Twenty-four family members had dysplastic nevi alone. An analysis of the cosegregation of the cutaneous malignant melanoma-dysplastic nevus t… Show more

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Cited by 302 publications
(126 citation statements)
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“…As well as being one of the most common karyotypic lesion seen in malignant melanomas, loss of alleles of 1p36 (now recognized as 1p36.31-36.32) was detected at a late event, or vertical phase to metastasis, in melanoma progression (Bale et al, 1989;Goldstein et al, 1993;Dracopoli et al, 1998;Poetsch et al, 2003). The skeletrophin gene was previously mapped to 1p36.2-3 by fluorescence in situ hybridization analysis (Takeuchi et al, 2003) and later confirmed by the human genome project to be in 1p36.32 and spanning about 14 kb.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…As well as being one of the most common karyotypic lesion seen in malignant melanomas, loss of alleles of 1p36 (now recognized as 1p36.31-36.32) was detected at a late event, or vertical phase to metastasis, in melanoma progression (Bale et al, 1989;Goldstein et al, 1993;Dracopoli et al, 1998;Poetsch et al, 2003). The skeletrophin gene was previously mapped to 1p36.2-3 by fluorescence in situ hybridization analysis (Takeuchi et al, 2003) and later confirmed by the human genome project to be in 1p36.32 and spanning about 14 kb.…”
Section: Discussionmentioning
confidence: 99%
“…Skeletrophin is located on human chromosome 1p36.32, where putative tumor suppressor factors involved in invasive melanoma have long been postulated (Bale et al, 1989;Goldstein et al, 1993;Dracopoli et al, 1998;Poetsch et al, 2003). In fact, a previous immunohistochemical staining revealed that invasive malignant melanoma did not express skeletrophin, whereas most benign nevi expressed skeletrophin in the cytoplasm (Takeuchi et al 2003).…”
Section: Introductionmentioning
confidence: 99%
“…Melanoma family DNA samples (derived from PBLs) used in our study were obtained from the NCI (NCI family numbers R, J and AH) and exhibited linkage to chromosome 1p36. [15][16][17] …”
Section: Melanoma Cell Lines and Tumor Specimensmentioning
confidence: 99%
“…The identification numbers of these DNAs were 7559206, 3234202, 0720200, 5864201, 0617200, and 0099204. These DNAs have been described previously (Bale et al, 1989).…”
Section: Tissue Dnasmentioning
confidence: 99%
“…A locus for familial cutaneous malignant melanoma-dysplastic naevus has been mapped to the region between an anonymous DNA marker (D1S47) and the gene locus for pronatrodilatin (NPPA) (Bale et al, 1989). To determine whether familial malanoma may carry peptide altering mutations in RIZ which maps just distal to NPPA, we performed SSCP analysis of DNAs from 6 familial melanoma patients.…”
Section: Lack Of Peptide Altering Mutations In Riz1 In Familial Melanmentioning
confidence: 99%