Mapping the human ZFX locus to Xp21.3 by in situ hybridization

Abstract

In situ hybridization using a probe specific for the human ZFX and ZFY loci assigns the ZFX gene to Xp21.3 and the ZFY gene to Yp11.32.

Effects of Emdogain on osteoblast gene expression

“…Many downregulated genes are involved in transcription. ZFY encodes a zinc finger‐containing protein that functions as a transcription factor (Muller and Schempp, 1989; Palmer et al , 1990; Dorit et al , 1995, 1996; Donnelly et al , 1996; Mahaffey et al , 1997). MSL3L1 encodes a nuclear protein and has similarity to drosophila male‐specific lethal‐3 gene (Prakash et al , 1999).…”

Report of the committee on the genetic constitution of the Y chromosome

“…In situ hybridization of DYS1 (probe 49f) (Quack et al, 1988) and ZFY (Muller and Schempp, 1989;Magenis et al, HGM10) has confirmed their positions on the deletion map.…”

“…The long range restriction map has been extended through the boundary to ZFY in the sex-specific region Verga and Erickson, 1989). A pseudoautosomal locus DXYS20 and the Y-specific locus ZFY have been mapped by in situ hybridization to the same distal band, Y pll.3 (Magcnis et al, HGM10;Muller and Schempp, 1989;Affara et al, 1989). This implies that the entire pseudoautosomal region is confined to the distal part of Y pll.3.…”

“…This gene is closely related to ZFX which is located on the X chromosome in the interval Xp22.1-Xp21.3 (Muller and Schempp, 1989;Affara et al, 1989;Schncidcr-Gadicke et al, 1989). The genomic sequence of the finger domain and the transcription products of ZFX and ZFY are distinguishable Schneider-Gadicke et al, 1989).…”

Inactivation of the Zfx gene on the mouse X chromosome.

“…These genes include ZFX (which encodes a zinc-finger protein) in Xp2l.3-22.1 (11)(12)(13)(14)(15), AIS9 in Xpll.3 (16,17), and RPS4X (which encodes the ribosomal protein S4) in Xql3.1 (18). Clearly, escape from X inactivation is not limited to the most distal portion of the short arm of the human X chromosome.…”