Mapping the link between cardiac biomarkers and chronic periodontitis: A clinico-biochemical study

Boyapati, Ramanarayana; Vudathaneni, Vijaya; Nadella, Swetha bharathi; Ramachandran, Radhika; Dhulipalla, Ravindranath; Adurty, Chaitanya

doi:10.4103/jisp.jisp_417_19

Cited by 12 publications

(6 citation statements)

References 25 publications

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“…45 Several studies have demonstrated the exacerbation of periodontal diseases in patients with chronic or severe systemic diseases; similar mechanisms of developing chronic and acute vascular reactions in the periodontal tissues have been observed in patients with some noninfectious and infectious diseases. [46][47][48] Indeed, in patients with coronavirus disease 2019 (COVID-19), a cytokine storm and thromboembolic complications were observed. 46 Such complications cause alterations in the oral cavity immune response and result in a severe course of periodontitis; a similar immune response is observed in obese individuals.…”

Section: Discussionmentioning

confidence: 99%

“…46 Chronic cardiovascular diseases, such as atherosclerosis, lead to dyslipidemia and chronic inflammation, which contribute to severe periodontal tissue alterations. 47 Furthermore, a pathological link between periodontal diseases and prostatitis was found, and patients with moderate and severe prostatitis had a significantly worse periodontal status. 48 Currently, it is thought that an inflammatory systemic factor that modifies the host immune response to periodontal pathogens plays an important role in the development of periodontal diseases.…”

Section: Discussionmentioning

confidence: 99%

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Changes in the periodontium against the background of systemic vascular reactions in young individuals with obesity

Skrypnyk¹,

Petrushanko²,

Непорада³

et al. 2023

Dent. Med. Probl.

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Background. Overweight and obesity are defined as abnormal or excessive fat accumulation that impairs health. The global prevalence of obesity has been increasing significantly among all age groups. Further more, obesity is a comorbid factor for numerous diseases, including cardiovascular and periodontal pathologies.Objectives. The present study aimed to investigate the influence of overweight and obesity on the peri odontium of young adults in relation to the functional state of the cardiovascular system. Material and methods.The oral health status of 132 males and females aged 18-22 years was exa mined. They were divided into 4 groups according to their body mass index (BMI): normal weight; over weight; class I obesity; and class II obesity. A periodontal chart, the records on oral hygiene and caries, and periodontal indices were provided for each participant. The main functional parameters of the cardiovascu lar system were measured before and after the dental examination.Results. Overweight or obesity did not affect the intensity of caries in young adults. The prevalence and severity of gingivitis were significantly higher in obese individuals. A moderate correlation was found be tween gingivitis and BMI in patients with class I and II obesity. Disturbances in the cardiovascular system function and in the autonomic nervous system tone were also diagnosed in obese patients. An impaired vascular response and significant functional changes in the cardiovascular system developed against the background of obesity. These changes show the development of subcompensation in young adults with obesity.Conclusions. In obese individuals, significantly worse oral hygiene was observed as compared to normal BMI patients. Moreover, the clinical manifestation and intensity of gingivitis in obese individuals were high even in those with satisfactory oral hygiene. In young obese individuals, the periodontal disease mani fested as gingivitis is due to significant adaptive and compensatory mechanisms.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Changes in the periodontium against the background of systemic vascular reactions in young individuals with obesity

Skrypnyk¹,

Petrushanko²,

Непорада³

et al. 2023

Dent. Med. Probl.

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“…We used the directed acyclic graph method [35] to construct the final multiple linear regression model. In creating the directed acyclic graph, we used factors that have been previously re-ported to be correlated with PISA and dementia to create a causal diagram (see the Supplementary Figure S1) [7,8,13,36]. We chose the number of present teeth as a representative value of oral status and excluded BOP (%), DI, CI, OHI-S and RSST from the final model because of collinearity.…”

Section: Discussionmentioning

confidence: 99%

“…The most widely-used measure for periodontal disease is the periodontal inflamed surface area (PISA) [4]. PISA has been reported to be correlated with many medical conditions, including hypertension [7], coronary heart disease [8], diabetes [9,10], and chronic kidney disease [11,12], and is also associated with smoking [13]. However, as far as we can tell, no studies have measured PISA in people with dementia.…”

Section: Introductionmentioning

confidence: 99%

Severity of Dementia Is Associated with Increased Periodontal Inflamed Surface Area: Home Visit Survey of People with Cognitive Decline Living in the Community

Edahiro

Okamura

Motohashi

et al. 2021

IJERPH

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No studies have measured the periodontal inflamed surface area in people with dementia, although periodontal disease is a major health issue in this group. This study aimed to determine the relationship between dementia severity and periodontal inflamed surface area. An interdisciplinary team, including a dentist and psychiatrist, conducted an in-home survey of older people living in the community. This cross-sectional study was designed as part of a larger cohort study. The interdisciplinary team visited 198 individuals with cognitive decline. We surveyed the clinical dementia rating, periodontal inflamed surface area, number of teeth, and other health issues. We used multiple linear regression analysis to assess the 75 people who were able to take part in all the visits. Number of teeth (Beta = 0.479, p < 0.001), clinical dementia rating (Beta = 0.258, p = 0.013), and age (Beta = 0.250, p = 0.017) were independently associated with periodontal inflamed surface area after adjusting for biological sex, depression, diabetes, collagen disease, visual disorder, and osteoporosis medication. To make communities more dementia-friendly, we must protect older people with dementia from developing poor oral health, which may require home visits for dental assessment.

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“…Periodontitis can trigger systemic inflammation by actuating the acute hepatic phase response owing to the possible bacteremia [ 19 , 20 ]. As low-grade inflammation, PD may represent one of several possible causal factors for heart diseases.…”

Section: Introductionmentioning

confidence: 99%

Assessment of the Relationship between Periodontitis and Cardiac Parameters in Patients with Early Chronic Heart Failure: A Cross-Sectional Study

Schulze,

Kwast,

Pökel

et al. 2024

JFMK

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Periodontal disease (PD) is considered a risk factor for cardiovascular events. However, its relationship to chronic heart failure (CHF) is unclear. The aim was to compare cardiac and inflammatory parameters in CHF patients with (PG) versus without periodontitis (NPG). The following parameters were recorded in 58 patients: periodontal screening and recording (PSR), troponin T, NT-proBNP, C-reactive protein (CRP), interleukin-6 (IL-6), blood pressure, heart rate, ejection fraction (EF), ventricular systolic and diastolic function parameters, incremental test, and three questionnaires (Mediterranean Diet Adherence Screener, MEDAS; Oral Health Impact Profile, OHIP-14; Patient Health Questionnaire, PHQ). The serum levels of NT-proBNP and troponin T were significantly higher in the PG, and the left ventricular systolic and diastolic function parameters were significantly lower. The correlation analysis showed age as the only independent risk factor for periodontitis and cardiac biomarkers. No significant group differences were found in the MEDAS, OHIP-14, and PHQ scores, or in CRP, IL-6, and cardiocirculatory parameters. Overall, the BMI correlated significantly with the mean PSR and total cholesterol. The occurrence of increased PSR together with increased age and cardiac risk parameters does not exclude an association between periodontitis and CHF, though no positive correlation was calculated. Periodontitis may be a modifiable risk factor for CHF. Its treatment may help to control the inflammatory burden.

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Mapping the link between cardiac biomarkers and chronic periodontitis: A clinico-biochemical study

Cited by 12 publications

References 25 publications

Changes in the periodontium against the background of systemic vascular reactions in young individuals with obesity

Changes in the periodontium against the background of systemic vascular reactions in young individuals with obesity

Severity of Dementia Is Associated with Increased Periodontal Inflamed Surface Area: Home Visit Survey of People with Cognitive Decline Living in the Community

Assessment of the Relationship between Periodontitis and Cardiac Parameters in Patients with Early Chronic Heart Failure: A Cross-Sectional Study

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