Mapping the metabolic characteristics of probiotic-fermented<i>Ganoderma lucidum</i>and its protective mechanism against Cd-induced nephrotoxicity

Dai, Zhen; Li, Gaoheng; Wang, Xixi; Gao, Bo; Gao, X.-L.; Strappe, Pádraig; Zhou, Zhongkai

doi:10.1039/d3fo01587d

Cited by 2 publications

(2 citation statements)

References 39 publications

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“…Interestingly, active compounds found in Ganoderma lucidum have shown protective effects against cadmium poisoning. Specifically, Ganoderma lucidum spore powder and polysaccharides demonstrated a protective capability against liver and kidney injury induced by cadmium poisoning, respectively [ 48 , 49 ], Additionally, triterpenoids from Ganoderma lucidum were effective in mitigating oxidative stress and inflammatory damage in chicken liver caused by cadmium [ 50 ].…”

Section: Discussionmentioning

confidence: 99%

The Protective Effects of Ganoderma lucidum Active Peptide GLP4 on Lung Injury Induced by Cadmium Poisoning in Mice

Zhu,

Wang,

Liu

2024

Toxics

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Ganoderma triterpenes and spore powder have shown promising results in mitigating cadmium-induced renal and hepatic injuries. Ganoderma lucidum active peptide GLP4 is a natural protein with dual antioxidant activities derived from the mycelium of Ganoderma lucidum. However, its efficacy in alleviating cadmium-induced lung injury remains unexplored. This study aims to investigate the protective effects of GLP4 against cadmium-induced lung injury in mice. Mice were exposed to cadmium chloride via nebulization to induce lung injury. The protective effect of GLP4 was assessed by measuring the total cell count in BALF, levels of inflammatory cytokines, and the expression of NLRP3 in lung tissues a through histopathological examination of lung tissue changes. The results showed that GLP4 significantly mitigated histopathological damage in lung tissues, decreased the secretion of inflammatory cytokines, and reduced the expression of NLRP3, which was elevated in cadmium-exposed mice. In vitro studies further revealed that GLP4 inhibited the cadmium-induced activation of the NLRP3 inflammasome. Notably, acute cadmium exposure by the respiratory tract did not affect the liver and kidneys of the mice. The findings suggest that GLP4 reduces cadmium-induced lung injury in mice by inhibiting the activation of the NLRP3 inflammasome, which provides a theoretical foundation for using Ganoderma lucidum as a preventive and therapeutic agent against cadmium poisoning.

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Section: Discussionmentioning

confidence: 99%

The Protective Effects of Ganoderma lucidum Active Peptide GLP4 on Lung Injury Induced by Cadmium Poisoning in Mice

Zhu,

Wang,

Liu

2024

Toxics

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“…11,12 Besides its nutritional contents, it has been reported to be used in the treatment of various conditions, including constipation, diabetes, hypercholesterolemia, migraine, lupus erythematosus, arthritis, hepatitis, bronchitis, anorexia, gastritis, hemorrhoids, nephritis, hypertension, dysmenorrhea, asthma and cardiovascular diseases. 8,12–17 Several triterpenoids have been isolated from G. lucidum and their therapeutic properties have been demonstrated by studies. 12,17–19 Some of these compounds, such as Ganoderic acid A, Ganodermanontriol, Ganoderic acid B and C derivatives, Ganoderic aldehyde A, Ganoderic acid C and D, and Ganoderic acid F, have been shown to possess hepatoprotective, anti-HIV, anti-hypercholesterolemia, anti-cancer, anti-histamine, and anti-angiogenic activities, respectively.…”

Section: Introductionmentioning

confidence: 99%

Ganoderma lucidum methyl ganoderate E extends lifespan and modulates aging-related indicators in Caenorhabditis elegans

Okoro,

Odiba,

Han

et al. 2024

Food Funct.

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Mapping the metabolic characteristics of probiotic-fermentedGanoderma lucidumand its protective mechanism against Cd-induced nephrotoxicity

Abstract: An animal model of Cd-induced kidney damage was designed to investigate the nephroprotective potential of the probiotic-fermented Ganoderma lucidum (served as FGL) via metabonomic analysis. The results showed that FGL...

Cited by 2 publications

References 39 publications

The Protective Effects of Ganoderma lucidum Active Peptide GLP4 on Lung Injury Induced by Cadmium Poisoning in Mice

The Protective Effects of Ganoderma lucidum Active Peptide GLP4 on Lung Injury Induced by Cadmium Poisoning in Mice

Ganoderma lucidum methyl ganoderate E extends lifespan and modulates aging-related indicators in Caenorhabditis elegans

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