Mapping the research trends of astrocytes in stroke: A bibliometric analysis

Abstract

BackgroundStroke, including ischemic stroke and hemorrhagic stroke, possesses complex pathological mechanisms such as neuroinflammation, oxidative stress and blood-brain barrier damage. Astrocyte functions have been reported during injury, neuroprotection and cell crosstalk. It plays a key role in exacerbating stroke injury, promoting neurological repair and enhancing neuroregeneration.AimThis holistic bibliometric analysis aimed to provide a general overview of the recent advancement and the hotspots in the field of stroke and astrocyte from 2001 to 2021.Materials and methodsPublications between 2001 and 2021, related to stroke and astrocyte were retrieved from the Web of Science (WOS) and analyzed in Gephi and VOSviewer.ResultsIn total, 3789 documents were extracted from the WOS databases. The publications showed stable growth since 2001. The United States and China were the most prolific countries and University of California San Francisco and Oakland University were the most influential institutes. The top four most productive journals were Brain Research, Journal of Cerebral Blood Flow and Metabolism, Glia and Journal of Neuroinflammation. Keywords frequency and co-occurrence analysis revealed that the topics related to “micro-RNA”, “toll like receptor”, “neuroinflammation”, “autophagy” and “interleukin” were research frontiers. The field of stroke and astrocyte focused on several aspects, such as the role of astrocytes in the treatment of stroke, metabolic changes in astrocytes, the protective role of apoptosis in astrocytes after oxidative stress injury and neurovascular units.ConclusionThis comprehensive bibliometric study provides an updated perspective on the trend of research associated with stroke and astrocyte. It will benefit scientific community to identify the important issues, future directions and provide a novel understanding of stroke pathophysiology, hotspots and frontiers to facilitate future research direction.

Exploring Research Trend and Hotspots on Oxidative Stress in Ischemic Stroke (2001–2022): Insights from Bibliometric

“…Data collection WOS core collection database is one of the most comprehensive, systematic and authoritative databases, containing over 13000 internationally recognized in uential academic journals that have been widely used for bibliometric analysis [19,20]. We referred to previous publications and developed search strategies related to oxidative stress and ischemic stroke (Table S2) [21,22]. Inclusion and exclusion criteria are shown in Fig.…”

Bibliometric Analysis of Stem Cells in Ischemic Stroke (2001-2022): Trends, Hotspots and Prospects

“…Bibliometric analysis is a statistical tool that provides an overview of a specific scientific research field, describes the research trends, and predicts the prospective future directions through qualitative and quantitative approaches [20]. In recent years, bibliometric analysis has been extensively used in stem cell research and the field of neuroscience [21][22][23]. In this study, we performed a bibliometric study of the literature on stem cells and ischemic stroke published between 2001 and 2022.…”

Shared metabolic shifts in endothelial cells in stroke and Alzheimer’s disease revealed by integrated analysis

“…As a type of neurological disease, stroke is the second major cause of death and a key contributor to disability-adjusted life years (DALYs). Approximately 101.47 million stroke events occurred globally in 2019, 12.2 million of which were new cases 3 . Studies have confirmed neurodegeneration secondary to stroke, which can cause progressive neuronal loss, cognitive and motor dysfunction, and ultimately dementia [4][5][6] .…”