Maqui berry exhibited therapeutic effects against DSS-induced ulcerative colitis in C57BL/6 mice

Zhou, Gao; Chen, Ling; Sun, Qing; Mo, Qigui; Sun, Wanchun; Wang, You-Wei

doi:10.1039/c9fo00663j

Cited by 33 publications

(22 citation statements)

References 42 publications

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“…Moreover, it has been demonstrated that other natural products decrease intracellular ROS levels in LPS-stimulated macrophages [52,53], indicating the close relationship between oxidative mechanisms and inflammation. An experimental study published by Zhou et al [29] showed that the ethyl acetate fraction of maqui extract (MWE) contained a high content of total phenols and flavonoid and that exhibited stronger antioxidant activities than the other extracts such as n-butanol fraction. Additionally, the authors proved that MWE considerably reduced the expression of COX-2 and IL-6 in LPS-stimulated RAW 264.7 cells, demonstrating the anti-inflammatory effect.…”

Section: Discussionmentioning

confidence: 99%

“…For example, pre-incubation of fibroblast and Caco-2 cells with anthocyanin rich maqui berry extract has shown a protective effect against OS along with a high capacity to inhibit human low-density lipoprotein (LDL) oxidation [28]. Additionally, the maqui extract exhibits an important anti-inflammatory effect in RAW 264.7 macrophages cells [29] by inhibition of gene expression of iNOS, COX-2, TNF-α, IL-6, and IL-10 [24,30].…”

Section: Introductionmentioning

confidence: 99%

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Native Chilean Berries Preservation and In Vitro Studies of a Polyphenol Highly Antioxidant Extract from Maqui as a Potential Agent against Inflammatory Diseases

et al. 2021

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The best conservation method for native Chilean berries has been investigated in combination with an implemented large-scale extract of maqui berry, rich in total polyphenols and anthocyanin to be tested in intestinal epithelial and immune cells. The methanolic extract was obtained from lyophilized and analyzed maqui berries using Folin–Ciocalteu to quantify the total polyphenol content, as well as 2,2-diphenyl-1-picrylhydrazyl (DPPH), ferric reducing antioxidant power (FRAP), and oxygen radical absorbance capacity (ORAC) to measure the antioxidant capacity. Determination of maqui’s anthocyanins profile was performed by ultra-high-performance liquid chromatography (UHPLC-MS/MS). Viability, cytotoxicity, and percent oxidation in epithelial colon cells (HT-29) and macrophages cells (RAW 264.7) were evaluated. In conclusion, preservation studies confirmed that the maqui properties and composition in fresh or frozen conditions are preserved and a more efficient and convenient extraction methodology was achieved. In vitro studies of epithelial cells have shown that this extract has a powerful antioxidant strength exhibiting a dose-dependent behavior. When lipopolysaccharide (LPS)-macrophages were activated, noncytotoxic effects were observed, and a relationship between oxidative stress and inflammation response was demonstrated. The maqui extract along with 5-aminosalicylic acid (5-ASA) have a synergistic effect. All of the compiled data pointed out to the use of this extract as a potential nutraceutical agent with physiological benefits for the treatment of inflammatory bowel disease (IBD).

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Native Chilean Berries Preservation and In Vitro Studies of a Polyphenol Highly Antioxidant Extract from Maqui as a Potential Agent against Inflammatory Diseases

et al. 2021

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“…These findings, at least in part, suggest that Ach may be involved in the suppression of iNOS and COX-2, and could be considered for the treatment of IBD, specifically in CD. In fact, a recent study has identified that the ethyl acetate fraction of maqui berry water extract considerably reduces the expression of COX-2 and iNOS in DSS-induced UC [ 54 ].…”

Section: Discussionmentioning

confidence: 99%

“…It is also possible that these effects may be significant in the long term, specifically in a recurrent model, and other antioxidant enzymes regulated by Nrf-2 could be involved during the first phase of oxidative and inflammation injury. Moreover, a recent relevant report showed that maqui extract could exert an important effect on the microbiota imbalance in IBD [ 54 ]. Our findings propose to consider Ach as a potential nutraceutical for preventive or curative treatment in acute phase inflammation in CD, modulating the oxidative status and inflammatory response.…”

Section: Discussionmentioning

confidence: 99%

Polyphenolic Maqui Extract as a Potential Nutraceutical to Treat TNBS-Induced Crohn’s Disease by the Regulation of Antioxidant and Anti-Inflammatory Pathways

et al. 2020

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Nutraceuticals include a wide variety of bioactive compounds, such as polyphenols, which have been highlighted for their remarkable health benefits. Specially, maqui berries have shown great antioxidant activity and anti-inflammatory effects on some inflammatory diseases. The objectives of the present study were to explore the therapeutic effects of maqui berries on acute-phase inflammation in Crohn’s disease. Balb/c mice were exposed to 2,4,6-trinitrobenzene sulfonic acid (TNBS) via intracolonic administration. Polyphenolic maqui extract (Ach) was administered orally daily for 4 days after TNBS induction (Curative Group), and for 7 days prior to the TNBS induction until sacrifice (Preventive Group). Our results showed that both preventive and curative Ach administration inhibited body weight loss and colon shortening, and attenuated the macroscopic and microscopic damage signs, as well as significantly reducing transmural inflammation and boosting the recovery of the mucosal architecture and its muco-secretory function. Additionally, Ach promotes macrophage polarization to the M2 phenotype and was capable of down-regulating significantly the expression of inflammatory proteins COX-2 and iNOS, and at the same time it regulates the antioxidant Nrf-2/HO-1 pathway. In conclusion, this is the first study in which it is demonstrated that the properties of Ach as could be used as a preventive and curative treatment in Crohn’s disease.

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“…Recently Zhou et al, (2019) reported that ethyl acetate fraction from maqui berry crude extract was rich in phenols and exhibited strong antioxidant and anti-inflammatory activities. They suggested that there was a possible prevention of cognitive damage due to the antioxidant activity of the maqui berry (Zhou et al, 2019). In a study with male rat brain exposed to ozone and treatment with extract of Maqui berry it was found that maqui berry extracts improved memory and decreased oxidative stress (Bribiesca-Cruz, Moreno, Garcí a-Viguera, Gallardo, Segura-Uribe, Pinto-Almazá n, & Guerra-Araiza, 2019).…”

Section: Health Benefitsmentioning

confidence: 99%

Bioactive Compounds, Antioxidant Activities, and Health Beneficial Effects of Selected Commercial Berry Fruits: A Review

Nemzer¹,

Kalita²,

Yashin³

et al. 2020

JFR

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Epidemiological studies have provided the evidence that regular consumption of fruits and vegetables reduce the risk of pathological condition such as cardiovascular disease, cancer, inflammation, and aging. Among fruits, berries are considered as superfruits due to their highly packed phytochemicals comprising phenolic acids, flavonoids viz. flavonols, flavanols, and anthocyanins. These bioactive compounds are associated with significant antioxidant, antidiabetic, antiinflammation, and anticancer properties. This review highlights the basic information and interesting findings of some selected commercial berries with their phytochemical composition, antioxidant properties, and potential health benefits to human.

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Maqui berry exhibited therapeutic effects against DSS-induced ulcerative colitis in C57BL/6 mice

Abstract: The effective extract fraction of maqui berry (Aristotelia chilensis) plays a therapeutic role in ulcerative colitis through its anti-inflammatory effect, reducing immune stress, and regulating gut microbiota.

Cited by 33 publications

References 42 publications

Native Chilean Berries Preservation and In Vitro Studies of a Polyphenol Highly Antioxidant Extract from Maqui as a Potential Agent against Inflammatory Diseases

Native Chilean Berries Preservation and In Vitro Studies of a Polyphenol Highly Antioxidant Extract from Maqui as a Potential Agent against Inflammatory Diseases

Polyphenolic Maqui Extract as a Potential Nutraceutical to Treat TNBS-Induced Crohn’s Disease by the Regulation of Antioxidant and Anti-Inflammatory Pathways

Bioactive Compounds, Antioxidant Activities, and Health Beneficial Effects of Selected Commercial Berry Fruits: A Review

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