Marasmius androsaceus mitigates depression-exacerbated intestinal radiation injuries through reprogramming hippocampal miRNA expression

Zhao, Jianlong; Zeng, Xiaozhou; Liu, Jessica; Liu, Xiaojing; Liu, Zhihong; Wang, Bin; Chen, Zhiyuan; Dong, Yanxi; Guo, Shu; Cui, Ming; Xiao, He; Liu, Xingzhong

doi:10.1016/j.biopha.2023.115157

Cited by 3 publications

(3 citation statements)

References 64 publications

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“…Fourteen of the studies used rats ( Matsuzaki et al, 2013 ; Minami et al, 2013 ; Tan et al, 2016 ; Liu C. et al, 2017 ; Song et al, 2017 ; Wang et al, 2017 ; Huang et al, 2020 ; Nascimento et al, 2020 ; Lin et al, 2021a ; Zhang L. et al, 2021 ; Lin et al, 2021b ; Anuar et al, 2022 ; Cheng, 2023 ; Rakoczy et al, 2023 ), while the remaining 36 studies used mice to test for antidepressant-like effects ( Zhou et al, 2005 ; Nishizawa et al, 2007 ; Koo et al, 2008 ; Singh et al, 2014 ; Tianzhu et al, 2014 ; Socala et al, 2015 ; Yao et al, 2015 ; Gupta et al, 2016 ; Huang et al, 2016 ; Nakamichi et al, 2016 ; Song et al, 2016 ; Xu, 2016 ; Bao et al, 2017 ; Liu Y. et al, 2017 ; Lin et al, 2017 ; Chiu et al, 2018 ; Mahmoudi et al, 2018 ; Ryu et al, 2018 ; Jin et al, 2019 ; Li et al, 2019 ; Song et al, 2020 ; Li H. et al, 2021 ; Li TJ. et al, 2021 ; Zhang T. et al, 2021 ; Chong et al, 2021 ; Hossen et al, 2021 ; Park et al, 2021 ; Singh et al, 2021 ; Zhao et al, 2021 ; Chou et al, 2022 ; Mi et al, 2022 ; Xin et al, 2022 ; Yu et al, 2022 ; Ezurike et al, 2023 ; Zhao et al, 2023 ; Hernandez-Leon et al, 2024 ). In terms of strains, 10 of the rat studies used Sprague-Dawley, three included Wistar and one used Long-Evans rats.…”

Section: Resultsmentioning

confidence: 99%

“…By far the most common animal model used to induce a depressive-like phenotype in rodents was the unpredictable chronic mild stress paradigm (UCMS), with 14 studies implementing this model ( Zhou et al, 2005 ; Tianzhu et al, 2014 ; Tan et al, 2016 ; Liu C. et al, 2017 ; Song et al, 2017 ; Wang et al, 2017 ; Li et al, 2019 ; Huang et al, 2020 ; Lin et al, 2021a ; Zhang L. et al, 2021 ; Lin et al, 2021b ; Zhao et al, 2021 ; Xin et al, 2022 ; Cheng, 2023 ); rats were used in the majority (9) of these studies. The second most frequent model involved the use of chronic restraint stress, in four mouse studies ( Nakamichi et al, 2016 ; Chiu et al, 2018 ; Chong et al, 2021 ; Zhao et al, 2023 ). Two rat studies used ovariectomy procedures to model menopausal depression ( Minami et al, 2013 ; Anuar et al, 2022 ), while high-dose corticosterone was administered to mice in two studies ( Chou et al, 2022 ; Yu et al, 2022 ).…”

Section: Resultsmentioning

confidence: 99%

“…( Minami et al, 2013 ), chronic restraint stress ( Pleurotus citrinopileatus, 14-day, 1,200 mg/kg, in food) ( Nakamichi et al, 2016 ) ( M. androsaceus , 14-day, i.g.) ( Zhao et al, 2023 ) and high-dose corticosterone (P-coumaric acid–compound found in some mushrooms, 3-day, 75 mg/kg, i.p.) ( Yu et al, 2022 ).…”

Section: Resultsmentioning

confidence: 99%

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A scoping review of the effects of mushroom and fungus extracts in rodent models of depression and tests of antidepressant activity

Wang,

Kim,

Aleksandrova

et al. 2024

Front. Pharmacol.

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One of the most important developments in psychopharmacology in the past decade has been the emergence of novel treatments for mood disorders, such as psilocybin for treatment-resistant depression. Psilocybin is most commonly found in different species of mushroom; however, the literature on mushroom and fungus extracts with potential antidepressant activity extends well beyond just psilocybin-containing mushrooms, and includes both psychedelic and non-psychedelic species. In the current review, we systematically review the preclinical literature on mushroom and fungus extracts, and their effects of animal models of depression and tests of antidepressant activity. The PICO structure, PRISMA checklist and the Cochrane Handbook for systematic reviews of intervention were used to guide the search strategy. A scoping search was conducted in electronic databases PubMed, CINAHL, Embase and Web of Science. The literature search identified 50 relevant and suitable published studies. These included 19 different species of mushrooms, as well as seven different species of other fungi. Nearly all studies reported antidepressant-like effects of treatment with extracts. Treatments were most commonly delivered orally, in both acute and chronically administered studies to predominantly male rodents. Multiple animal models of depression were used, the most common being unpredictable chronic mild stress, while the tail suspension test and forced swim test were most frequently used as standalone antidepressant screens. Details on each experiment with mushroom and fungus species are discussed in detail, while an evaluation is provided of the strengths and weaknesses of these studies.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

A scoping review of the effects of mushroom and fungus extracts in rodent models of depression and tests of antidepressant activity

Wang,

Kim,

Aleksandrova

et al. 2024

Front. Pharmacol.

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The Radioprotective Effect of LBP on Neurogenesis and Cognition after Acute Radiation Exposure

Yin,

Wang,

et al. 2024

CRP

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Background: Radiation exposure has been linked to the development of brain damage and cognitive impairment, but the protective effect and mechanism of Lycium barbarum pills (LBP) on radiation-induced neurological damage remains to be clarified. Methods: Behavioral tests and immunohistochemical studies were conducted to evaluate the protective effects of LBP extract (10 g/kg orally daily for 4 weeks) against radiation-induced damage on neurogenesis and cognitive function in Balb/c mice exposed to 5.5 Gy X-ray acute radiation. objective: To study the protective effect and mechanism of Lycium barbarum pills(LBP) on radiation induced neurological damage. Results: The results showed that the LBP extract significantly improved body weight loss, locomotor activity and spatial learning and memory. Immunohistochemical tests revealed that the LBP extract prevented the loss of proliferating cells, newly generated neurons and interneurons, especially in the subgranular area of the dentate gyrus. Conclusion: The findings suggest that LBP is a potential neuroprotective drug for mitigating radiation-induced neuropsychological disorders.

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Role of miRNAs in Brain Development

Sharma,

Kaushik,

Goswami

et al. 2024

MIRNA

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Non-coding RNAs that are small in size, called microRNAs (miRNAs), exert a conse-quence in neutralizing gene activity after transcription. The nervous system is a massively ex-pressed organ, and an expanding body of research reveals the vital functions that miRNAs play in the brain's growth and neural activity. The significant benefit of miRNAs on the development of the central nervous system is currently shown through new scientific methods that concentrate on targeting and eradicating vital miRNA biogenesis pathways the elements involving Dicer and DGCR8. Modulation of miRNA has been associated with numerous essential cellular processes on neural progenitors, like differentiation, proliferation, and destiny determination. Current re-search discoveries that emphasize the significance of miRNAs in the complex process of brain development are included in this book. The miRNA pathway plays a major role in brain devel-opment, its operational dynamics, and even diseases. Recent studies on miRNA-mediated gene regulation within neural discrepancy, the circadian period and synaptic remodeling are signs of this. We also discussed how these discoveries may affect our comprehension of the fundamental processes behind brain diseases, highlighting the novel therapeutic opportunities miRNAs pro-vide for treating various human illnesses.

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Marasmius androsaceus mitigates depression-exacerbated intestinal radiation injuries through reprogramming hippocampal miRNA expression

Cited by 3 publications

References 64 publications

A scoping review of the effects of mushroom and fungus extracts in rodent models of depression and tests of antidepressant activity

A scoping review of the effects of mushroom and fungus extracts in rodent models of depression and tests of antidepressant activity

The Radioprotective Effect of LBP on Neurogenesis and Cognition after Acute Radiation Exposure

Role of miRNAs in Brain Development

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