Health training in the field of sexual and gender diversity, and related to specific health needs of trans* people, has not been incorporated into nursing degree study plans in Spain., although the need of specific training in this field are reported in the scientific literature. In this sense, the role of the teacher as a facilitator and collaborator of self-directed learning by students, is particularly interesting, through new teaching methodological strategies such as Problem-Based Learning and Film-forum. The objective of this study was to generate an educational intervention, about trans* people, for last year nursing students, using both teaching methodologies; and assess the impact and satisfaction with the training received. The results showed a high statistical significance in the acquisition of knowledge, without finding differences either with the methodologies used or in the degree of satisfaction between the two ones.