Marathon run: effects on blood cortisol — ACTH, iodothyronines — TSH and vasopressin

Dessypris, A.; Wägar, Gustav; Fyhrquist, F; Mäkinen, Tuula; Welin, M.; Lamberg, B.‐A.

doi:10.1530/acta.0.0950151

Cited by 35 publications

(21 citation statements)

References 14 publications

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“…The increase of cortisol after the marathon confirms previous data from other endurance performances [1,8,14,15]. The cortisol increased after acclimatization, de noting the stress as a result of altitude variation, even though the change was not statistically significant.…”

Section: Discussionsupporting

confidence: 88%

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Cortisol, Testosterone, and Free Testosterone in Athletes Performing a Marathon at 4,000 m Altitude

Marinelli¹,

Roi²,

Giacometti

et al. 1994

Horm Res

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Cortisol, testosterone, free testosterone and the ratio between free testosterone and cortisol (FTCR) were monitored in six athletes participating in a marathon starting at 3,860 and finishing at 3,400 m, having reached the top at 5,100 m altitude. Blood was drawn at sea level before the departure for the mountain area, after a week of acclimatization, immediately after the marathon and after a 24-hour recovery period from the run. Cortisol increased after acclimatization and especially after the marathon; it decreased to normal values after recovery. Testosterone decreased after acclimatization, especially after the run; it presented a partial recovery 24 h after the race. Free testosterone did not decrease after acclimatization and presented partial recovery. FTCR could also be useful for monitoring fitness, overtraining and overstrain in strenuous and ultraendurance exercise.

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Section: Discussionsupporting

confidence: 88%

“…Few reports have been published about hormonal blood changes during strenuous and exhaustive exercise [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

Cortisol, Testosterone, and Free Testosterone in Athletes Performing a Marathon at 4,000 m Altitude

Marinelli¹,

Roi²,

Giacometti

et al. 1994

Horm Res

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“…This suggests that cortisol’s actions may be seen in a wider range of structures during stress as opposed to the resting state. Future work should map the response to a range of doses that might approximate the levels of cortisol seen during mild and severe psychological stress and occurring during physiological stressors, such as a marathon run, which produces blood levels far higher than the current dose (Dessypris, et al, 1980). Whether the direction of effect or the range of structures affected would remain the same is therefore a question for further study (van Stegeren, 2009).…”

Section: Discussionmentioning

confidence: 99%

Acute effects of hydrocortisone on the human brain: An fMRI study

Lovallo

Robinson

Glahn

et al. 2010

Psychoneuroendocrinology

110

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Cortisol is essential for regulating all cell types in the body, including those in the brain. Most information concerning cortisol’s cerebral effects comes from work in nonhumans. This is a first effort to use functional magnetic resonance imaging (fMRI) to study the time course and locus of cortisol’s effects on selected brain structures in resting humans. We repeatedly scanned 21 healthy young adults over 45 min to examine changes in the brain’s activity 5 min before, and for 40 min after, an IV injection of 10 mg of hydrocortisone (N = 11) or saline placebo (N = 10). At 15–18 min postinjection we observed in the hydrocortisone group reduced activity in the hippocampus and amygdala that reached a peak response minimum at 25–30 min postinjection (−1 Standard Deviation) relative to placebo. No such effect was seen in the thalamus. Functional MRI appears to be a safe, noninvasive method to study the time course and anatomical effects of glucocorticoids in the human brain.

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“…The short half-life (10–20 minutes) 4,5 and moderate amount of plasma (0.5–1.0 mL) required to measure bioactive AVP makes appropriate blood collection and processing difficult, particularly in field settings. 2,3,6–8 Additionally, the technical difficulties and labor intensive process of accurately quantifying AVP within physiologically meaningful ranges (0–5 pg/mL) makes both the cost and the availability of AVP measurement prohibitive to many scientists performing research at athletic events.…”

Section: Introductionmentioning

confidence: 99%

Changes in Copeptin and Bioactive Vasopressin in Runners With and Without Hyponatremia

Hew‐Butler¹,

Hoffman²,

Stuempfle³

et al. 2011

Clinical Journal of Sport Medicine

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Objective To evaluate changes in both the N-terminal (arginine vasopressin; AVP) and C-terminal (copeptin) fragments of the vasopressin prohormone before, during, and after an ultramarathon race and to assess vasopressin and copeptin concentrations in runners with and without hyponatremia. Design Observational study. Setting Three trials (2 sodium balance and 1 hyponatremia treatment) in 2 separate approximately 160-km footraces [Western States Endurance Run (WSER) and Javelina Jundred Mile Race (JJ100)]. Participants Six hyponatremic and 20 normonatremic runners; 19 finishers with 7 completing 100 km. Main Outcome Measures Plasma AVP ([AVP]p), copeptin ([copeptin]p), sodium ([Na+]p), and protein (%plasma volume change; %PV) concentrations. Results In the WSER Sodium Trial, a 3-fold prerace to postrace increase in both [AVP]p (0.7 ± 0.4 to 2.7 ± 1.9 pg/mL; P < 0.05) and [copeptin]p (10.3 ± 12.5 to 28.2 ± 16.3 pmol/L; nonsignificant) occurred, despite a 2 mEq/L decrease in [Na+]p (138.7 ± 2.3 to 136.7 ± 1.6 mEq/L; NS). A significant correlation was noted between [AVP]p and [copeptin]p postrace (r = 0.82; P < 0.05). In the WSER Treatment Trial, despite the presence of hyponatremia pre-treatment versus posttreatment ([Na+]p = 130.3 vs 133.5 mEq/L, respectively), both [AVP]p (3.2 vs 2.1 pg/mL) and [copeptin]p (22.5 vs 24.9 pmol/L) were well above the detectable levels. A significant correlation was noted between [AVP]p and [copeptin]p 60 minutes after treatment (r = 0.94; P < 0.05). In the JJ100 Sodium Trial, significant correlations were found between [copeptin]p change and %PV change (r = −0.34; P < 0.05) and between [AVP]p change and [Na+]p change (r = 0.39; P < 0.05) but not vice-versa. Conclusions [Copeptin]p seems to be a reliable surrogate of stimulated [AVP]p during exercise. Nonosmotic vasopressin stimulation occurs during ultradistance running. [Copeptin]p may better reflect chronic (%PV) vasopressin secretion under conditions of endurance exercise.

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Marathon run: effects on blood cortisol — ACTH, iodothyronines — TSH and vasopressin

Cited by 35 publications

References 14 publications

Cortisol, Testosterone, and Free Testosterone in Athletes Performing a Marathon at 4,000 m Altitude

Cortisol, Testosterone, and Free Testosterone in Athletes Performing a Marathon at 4,000 m Altitude

Acute effects of hydrocortisone on the human brain: An fMRI study

Changes in Copeptin and Bioactive Vasopressin in Runners With and Without Hyponatremia

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