Marcadores biológicos de tumores tiroidianos

Matsuo, Sílvia E.; Martins, Luciane; Leoni, S; Hajjar, Denise; Ricarte-Filho, Julio C.; Ebina, Kátia N.; Kimura, Edna Teruko

doi:10.1590/s0004-27302004000100013

Cited by 19 publications

(16 citation statements)

References 67 publications

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“…Lantuejoul et al, demostraron que los tumores con un mayor número de metástasis ganglionares tenían una mayor expresión de VEGF 14 . Una situación semejante ha sido descrita para la catenina en pacientes con carcinomas diferenciados del tiroides que al sobreexpresar esta proteína aparecen con una mayor frecuencia de metástasis ganglionares 16 .…”

Section: Discussionunclassified

Características de presentación del microcarcinoma papilar del tiroides: Experiencia retrospectiva de los últimos 12 años

et al. 2005

Rev. méd. Chile

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(15 and 2.5%, respectively, p <0.001, for the former; 32.4 and 1.7%, respectively, p <0.001, for the latter). Conclusions: In this series, one third of microcarcinomas were multifocal and 10% had lymph node involvement. Therefore, the aggressiveness of these tumors is higher than what is reported in the literature and they should be treated with total thyroidectomy (Rev Méd Chile 2005; 133: 1305-10).

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Section: Discussionunclassified

Características de presentación del microcarcinoma papilar del tiroides: Experiencia retrospectiva de los últimos 12 años

et al. 2005

Rev. méd. Chile

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“…As proteínas ras, componentes das vias de sinalização, são lideradas por receptores de membrana celular no controle da proliferação e na diferenciação ou morte celular, por isso elas têm uma grande importância na tumorigênese e na progressão tumoral em diversos tecidos (REBOLLO; MARTÍNEZ, 1999;MATSUO et al, 2004). Quando a função de ras é inibida ou inativada, a proliferação celular ou a diferenciação podem não ocorrer.…”

Section: Aspectos Molecularesunclassified

Aspectos biológicos e atividade tumorigênica da família proto-oncogênica Ras

Boquett

Ferreira

2010

Semina: Ciências Biológicas e da Saúde

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ResumoOs proto-oncogenes desempenham importante papel na regulação do ciclo celular, e são críticos à tumorigênese. Nessa categoria se encontra a família RAS, que, devido ao elevado potencial transformante dos genes que a compõem, é uma das mais bem descritas e estudadas. É formada pelos genes H-, K-e N-RAS, que codificam proteínas altamente relacionadas expressas em vários tipos de células, denominadas p21. Estas atuam na transdução de sinal da membrana ao núcleo, estão envolvidas no controle da proliferação, diferenciação e morte celular e são reguladas pela interação com GDP (inativa) e GTP (ativa). As proteínas p21 diferem em apenas 10-15% da sua estrutura primária, na porção C-terminal, denominada região hipervariante. Quando na forma oncogênica, permanecem ativas, e conferem estímulo contínuo à proliferação celular. Dentre os genes RAS, K-RAS tem sido o mais estudado, por apresentar mutações mais freqüentes e presentes em tumores mais agressivos, e implicar em menor sobrevida aos pacientes. Pelo importante papel já demonstrado na formação de tumores e relativa carência de bibliografia em língua portuguesa acerca dessa família gênica, apresentamos neste trabalho uma revisão sistematizada e atualizada sobre os proto-oncogenes RAS. Palavras-chave: K-RAS, p21. Oncogene. Transdução de sinal. AbstractProto-oncogenes play an important role in the regulation of the cellular cycle, being critical to the tumorigenesis. In this category we can find the RAS family. Due to the high transformation potential of these genes, this family is the best described and most studied one. It is formed by the H-, K-and the N-RAS genes, that codify highly related proteins expressed in several types of cells, denominated p21.These proteins act in the sign transduction from the membrane to the nucleus, as well as in the control of proliferation, differentiation and cellular death, and they are regulated by the interaction with GDP (inactive) and GTP (active). These proteins show variation in only 10 -15% of the primary structure, in the C-terminal portion denominated hyper-variant region. When in the oncogenic form, the p21 proteins remain active, providing continuous stimuli to the cellular proliferation. Among the RAS genes, K-RAS ones have been the most studied for presenting more frequent mutations and for being present in more aggressive tumors, implying the patients' shorter survival time. Due to these facts and relative bibliography lack in the Portuguese language on this family, we presented in this work a systematized and updated review on the RAS genes.

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“…Mutation of p53 is rare in patients with differentiated carcinomas but common in anaplastic carcinoma. 3,4 The occurrence rate for thyroid nodules is between 4 and 7%. However, the occurrence has been increasing (30%), probably due to new technology that detects small thyroid cancers that may not have been found previously.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of thyroid tissue by Raman spectroscopy

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Santos

et al. 2010

Biomedical Vibrational Spectroscopy IV: Advances in Research and Industry

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Thyroid gland is a small gland in the neck consisting of two lobes connected by an isthmus. Thyroid's main function is to produce the hormones thyroxine (T4), triiodothyronine (T3) and calcitonin. Thyroid disorders can disturb the production of these hormones, which will affect numerous processes within the body such as: regulating metabolism and increasing utilization of cholesterol, fats, proteins, and carbohydrates. The gland itself can also be injured; for example, neoplasias, which have been considered the most important, causing damage of to the gland and are difficult to diagnose. There are several types of thyroid cancer: Papillary, Follicular, Medullary, and Anaplastic. The occurrence rate, in general is between 4 and 7%; which is on the increase (30%), probably due to new technology that is able to find small thyroid cancers that may not have been found previously. The most common method used for thyroid diagnoses are: anamnesis, ultrasonography, and laboratory exams (Fine Needle Aspiration Biopsy-FNAB). However, the sensitivity of those test are rather poor, with a high rate of false-negative results, therefore there is an urgent need to develop new diagnostic techniques. Raman spectroscopy has been presented as a valuable tool for cancer diagnosis in many different tissues. In this work, 27 fragments of the thyroid were collected from 18 patients, comprising the following histologic groups: goitre adjacent tissue, goitre nodular tissue, follicular adenoma, follicular carcinoma, and papillary carcinoma. Spectral collection was done with a commercial FT-Raman Spectrometer (Bruker RFS100/S) using a 1064 nm laser excitation and Ge detector. Principal Component Analysis, Cluster Analysis, and Linear Discriminant Analysis with cross-validation were applied as spectral classification algorithm. Comparing the goitre adjacent tissue with the goitre nodular region, an index of 58.3% of correct classification was obtained. Between goitre (nodular region and adjacent tissue) and papillary carcinoma, the index of correct classification was 64.9%, and the classification between benign tissues (goitre and follicular adenoma) and malignant tissues (papillary and follicular carcinomas), the index was 72.5%.

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Marcadores biológicos de tumores tiroidianos

Cited by 19 publications

References 67 publications

Características de presentación del microcarcinoma papilar del tiroides: Experiencia retrospectiva de los últimos 12 años

Características de presentación del microcarcinoma papilar del tiroides: Experiencia retrospectiva de los últimos 12 años

Aspectos biológicos e atividade tumorigênica da família proto-oncogênica Ras

Evaluation of thyroid tissue by Raman spectroscopy

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