Objectives.-To examine relationships between short-term and long-term exposures to unconventional natural gas development, commonly known as fracking, and county hospitalization rates for a variety of broad disease categories.
StudyDesign.-This is an ecological study based on county-level data for Pennsylvania, United States, 2003-2014.Methods.-We estimated multivariate regressions with county and year fixed effects, using two twelve-year panels: all 67 Pennsylvania counties and 54 counties that are not large metropolitan.Results.-After correcting for multiple comparisons, we found a positive association of cumulative well density (per km 2 ) with genitourinary hospitalization rates. When large metropolitan counties were excluded, this relationship persisted, and positive associations of skinrelated hospitalization rates with cumulative well count and well density were observed. The association with genitourinary hospitalization rates is driven by females in the 20-64y.o. group, particularly for kidney infections, calculus of ureter, and urinary tract infection. Contemporaneous wells drilled were not significantly associated with hospitalizations after adjustment for multiple comparisons.