Marchiafava-Bignami disease with widespread extracallosal lesions and favourable course

Ruiz-Martínez, D. J.; Pérez-Balsa, A. Martínez; Ruibal, M.; Urtasun, Miguel; Villanúa, Jorge; Massó, Jose Félix Martí

doi:10.1007/s002340050702

Cited by 42 publications

(30 citation statements)

References 3 publications

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“…Involvement of major parts of the corpus callosum is common in type A [31,32] whereas in type B, cystic lesions tend to be smaller and of more focal distribution [4,43]. In both forms, the extension of callosal edema in the acute stage may markedly exceed areas of ultimate cystic necrosis, and, as indicated before, reversibility of T2-hyperintense lesions has been documented in cases lacking evidence of cystic-necrotic lesions by imaging in vivo [20,46].…”

Section: Discussionmentioning

confidence: 91%

Clinicoradiologic subtypes of Marchiafava-Bignami disease

2004

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The clinical diagnosis of Marchiafava-Bignami disease (MBD) has considerably changed during recent decades with brain MRI providing the opportunity of a reliable in-vivo diagnosis. However, semiologic and neuroimaging characteristics of the currently known spectrum of MBD have not been investigated systematically, and knowledge of clinicoradiologic associations is sketchy. We report an illustrative case with limited callosal involvement on MRI and a favorable outcome and have reviewed literature on clinical and radiologic features in 50 cases of MBD diagnosed in vivo since 1985. Our reviewed data suggest the differentiation of two clinicoradiologic subtypes: Type A is characterized by major impairment of consciousness, T2-hyperintense swelling of the entire corpus callosum on early MRI and poor outcome. Type B shows at most slight impairment of consciousness, partial callosal lesions on MRI and a favorable outcome. Differentiation of these clinicoradiologic subtypes may help resolve inconsistencies of the established clinical classification resulting from new insights into the clinical course and prognosis of MBD by structural neuroimaging.

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Section: Discussionmentioning

confidence: 91%

Clinicoradiologic subtypes of Marchiafava-Bignami disease

2004

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“…Involvement of hemispheric white matter has been described in 40% of necropsy cases of known MBD (38). Furthermore, more involvement of the cortex has also been reported (39).…”

Section: Changes In the Corpus Callosummentioning

confidence: 95%

Your Brain on Drugs: Imaging of Drug-related Changes in the Central Nervous System

Tamrazi¹,

Almast²

2012

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Drug abuse is a substantial problem in society today and is associated with significant morbidity and mortality. Various drugs are associated with serious complications affecting the brain, and it is critical to recognize the imaging findings of these complications to provide prompt medical management. The central nervous system (CNS) is a target organ for drugs of abuse as well as specific prescribed medications. Drugs of abuse affecting the CNS include cocaine, heroin, alcohol, amphetamines, toluene, and cannabis. Prescribed medications or medical therapies that can affect the CNS include immunosuppressants, antiepileptics, nitrous oxide, and total parenteral nutrition. The CNS complications of these drugs include neurovascular complications, encephalopathy, atrophy, infection, changes in the corpus callosum, and other miscellaneous changes. Imaging abnormalities indicative of these complications can be appreciated at both magnetic resonance (MR) imaging and computed tomography (CT). It is critical for radiologists to recognize complications related to drugs of abuse as well as iatrogenic effects of various medications. Therefore, diagnostic imaging modalities such as MR imaging and CT can play a pivotal role in the recognition and timely management of drug-related complications in the CNS.

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“…Similar features have been reported in Marchiafava-Bignami disease. Originally described as a histopathological finding in heavy drinkers post mortem, it has later been recognized to occur associated with alcoholism more often and with milder clinical symptoms than initially presumed [24, 25]. Lesions of the corpus callosum are not part of the typical MRI features of Alexander disease.…”

Section: Discussionmentioning

confidence: 99%

A Novel <i>GFAP</i> Mutation and Disseminated White Matter Lesions: Adult Alexander Disease?

Brockmann

Meins²,

Taubert³

et al. 2003

Eur Neurol

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The recent discovery of heterozygous de novo mutations in the glial fibrillary acidic protein (GFAP) gene as the cause of infantile and juvenile Alexander disease has shed new light on the long-standing debate whether the adult subtype has the same etiology as infantile and juvenile Alexander disease. A 40-year-old man presented with subacute left hemiplegia and ataxia. Cranial MRI revealed disseminated patchy white matter changes involving the corpus callosum, basal ganglia and brainstem. CSF investigation demonstrated elevated total protein but was otherwise normal. Mutation analysis of the GFAP gene was performed in the patient, his mother and healthy brother. A novel heterozygous mutation in exon 4, 681G→C, predicting an amino acid substitution E223Q in the rod region of GFAP was detected in the patient and his mother but not in his healthy brother or 150 control chromosomes. We conclude that the patient is actually afflicted with Alexander disease. Mutation analysis of GFAP should be considered in patients with remitting neurological deficits, disseminated white matter lesions and absence of inflammatory CSF changes.

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Marchiafava-Bignami disease with widespread extracallosal lesions and favourable course

Cited by 42 publications

References 3 publications

Clinicoradiologic subtypes of Marchiafava-Bignami disease

Clinicoradiologic subtypes of Marchiafava-Bignami disease

Your Brain on Drugs: Imaging of Drug-related Changes in the Central Nervous System

A Novel <i>GFAP</i> Mutation and Disseminated White Matter Lesions: Adult Alexander Disease?

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