Marek's Disease: Effects of
            <i>B</i>
            Histocompatibility Alloalleles in Resistant and Susceptible Chicken Lines

Briles, W. E.; Stone, Howard A.; Cole, R. K.

doi:10.1126/science.831269

Cited by 324 publications

(153 citation statements)

References 30 publications

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“…Host genetic resistance to MD was first noticed in the 1940s [16][17][18]. It was during and after the 1970s that researchers, using specialized experimental lines of chickens, identified and confirmed that major histocompatibility complex (MHC), the B-haplotypes in chicken, significantly contributes to genetic resistance against MD [19][20][21][22][23][24][25][26][27]. Soon after, genes outside of the MHC were also shown to contribute to MD resistance [28,29].…”

Section: Introductionmentioning

confidence: 99%

Genomic Variation between Genetic Lines of White Leghorns Differed in Resistance to Marek’s Disease

Xie¹,

Chang²,

Dong³

et al. 2017

J Clin Epigenet

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Section: Introductionmentioning

confidence: 99%

Genomic Variation between Genetic Lines of White Leghorns Differed in Resistance to Marek’s Disease

Xie¹,

Chang²,

Dong³

et al. 2017

J Clin Epigenet

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“…In the chicken, the association between MHC polymorphism and resistance or susceptibility differences to infectious pathogens had long been recognised [13,78]. In most reports, the MHC is outlined in association to resistance or susceptibility to specific agents such as the Marek's disease virus (MDV).…”

Section: Introductionmentioning

confidence: 99%

Immunological basis of differences in disease resistance in the chicken

Zekarias

Huurne²,

Landman

et al. 2002

Vet. Res.

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-Genetic resistance to diseases is a multigenic trait governed mainly by the immune system and its interactions with many physiologic and environmental factors. In the adaptive immunity, T cell and B cell responses, the specific recognition of antigens and interactions between antigen presenting cells, T cells and B cells are crucial. It occurs through a network of mediator proteins such as the molecules of the major histocompatibility complex (MHC), T cell receptors, immunoglobulins and secreted proteins such as the cytokines and antibodies. The diversity of these proteins that mainly is due to an intrinsic polymorphism of the genes causes phenotypic variation in disease resistance. The well-known linkage of MHC polymorphism and Marek's disease resistance difference represents a classic model revealing immunological factors in resistance differences and diversity of mediator molecules. The molecular bases in any resistance variation to infectious pathogens are vaguely understood. This paper presents a review of the major immune mediators involved in resistance and susceptibility to infectious diseases and their functional mechanisms in the chicken. The genetic interaction of disease resistance with production traits and the environment is mentioned. et les interactions entre les cellules présentant des antigènes, les cellules T et B, sont cruciales. Cela se produit à travers un réseau de protéines médiatrices telles que les molécules du complexe majeur d'histocompatibilité (CMH), les récepteurs des cellules T, les immunoglobulines et les protéines sé-crétées telles que les cytokines et les anticorps. La diversité de ces protéines, qui est surtout due au polymorphisme intrinsèque des gènes, entraîne une variation phénotypique dans la résistance aux maladies. Le lien bien connu entre le polymorphisme du CMH et les différences dans la résistance à la maladie de Marek représente un modèle classique révélant les facteurs immunologiques dans les différences de résistance et la diversité dans les molécules médiatrices. Les bases moléculaires impliquées dans toute variation de résistance aux pathogènes infectieux sont à peu près comprises. Cet article présente une synthèse sur les principaux médiateurs de l'immunité impliqués dans la résis-tance et la sensibilité aux maladies infectieuses chez le poulet et leurs mécanismes fonctionnels. L'interaction génétique entre la résistance aux maladies et les traits de production et l'environnement est mentionnée.

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“…MHC diversity contributes to pathogen defense in a population (34,35). Association of specific MHC haplotypes with disease resistance can be readily demonstrated in the chicken, such as B21 and resistance to Marek disease (36). Heterozygote-advantage and rare-allele advantage, or antagonistic coevolution of host and virus whereby rare alleles to which viruses have not yet adapted have an advantage (37), maintain the MHC diversity in populations.…”

mentioning

confidence: 99%

Extensive Allelic Diversity of MHC Class I in Wild Mallard Ducks

Fleming-Canepa

Jensen

Mesa

et al. 2016

The Journal of Immunology

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MHC class I is critically involved in defense against viruses, and diversity from polygeny and polymorphism contributes to the breadth of the immune response and health of the population. In this article, we examine MHC class I diversity in wild mallard ducks, the natural host and reservoir of influenza A viruses. We previously showed domestic ducks predominantly use UAA, one of five MHC class I genes, but whether biased expression is also true for wild mallards is unknown. Using RT-PCR from blood, we examined expressed MHC class I alleles from 38 wild mallards (Anas platyrhynchos) and identified 61 unique alleles, typically 1 or 2 expressed alleles in each individual. To determine whether expressed alleles correspond to UAA adjacent to TAP2 as in domestic ducks, we cloned and sequenced genomic UAA-TAP2 fragments from all mallards, which matched transcripts recovered and allowed us to assign most alleles as UAA. Allelic differences are primarily located in α1 and α2 domains in the residues known to interact with peptide in mammalian MHC class I, suggesting the diversity is functional. Most UAA alleles have unique residues in the cleft predicting distinct specificity; however, six alleles have an unusual conserved cleft with two cysteine residues. Residues that influence peptide-loading properties and tapasin involvement in chicken are fixed in duck alleles and suggest tapasin independence. Biased expression of one MHC class I gene may make viral escape within an individual easy, but high diversity in the population places continual pressure on the virus in the reservoir species.

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Marek's Disease: Effects of B Histocompatibility Alloalleles in Resistant and Susceptible Chicken Lines

Cited by 324 publications

References 30 publications

Genomic Variation between Genetic Lines of White Leghorns Differed in Resistance to Marek’s Disease

Genomic Variation between Genetic Lines of White Leghorns Differed in Resistance to Marek’s Disease

Immunological basis of differences in disease resistance in the chicken

Extensive Allelic Diversity of MHC Class I in Wild Mallard Ducks

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