Margin Evaluation in the Presence of Deformation, Rotation, and Translation in Prostate and Entire Seminal Vesicle Irradiation With Daily Marker-Based Setup Corrections

Mutanga, Theodore F.; Boer, Hans C.J. de; Wielen, Gerard J. van der; Hoogeman, M.; Incrocci, Luca; Heijmen, B.

doi:10.1016/j.ijrobp.2010.09.013

Cited by 51 publications

(49 citation statements)

References 22 publications

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“…These findings are supported in the studies by van der Wielen et al, (16) Dehnad et al, (20) and Deurloo et al (17) where fiducial markers implanted into the prostate and CT prostate delineation, respectively, were used to investigate the prostate deformation. Other studies 18 , 19 have found that prostate deformation can occur and is an important source of uncertainty in radiotherapy of prostate cancer. An endorectal coil is frequently used to improve the MR quality and to limit prostate movement.…”

Section: Introductionmentioning

confidence: 99%

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Comparison of manual and automatic MR‐CT registration for radiotherapy of prostate cancer

Korsager

Carl

Østergaard

2016

J Applied Clin Med Phys

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In image‐guided radiotherapy (IGRT) of prostate cancer, delineation of the clinical target volume (CTV) often relies on magnetic resonance (MR) because of its good soft‐tissue visualization. Registration of MR and computed tomography (CT) is required in order to add this accurate delineation to the dose planning CT. An automatic approach for local MR‐CT registration of the prostate has previously been developed using a voxel property‐based registration as an alternative to a manual landmark‐based registration. The aim of this study is to compare the two registration approaches and to investigate the clinical potential for replacing the manual registration with the automatic registration. Registrations and analysis were performed for 30 prostate cancer patients treated with IGRT using a Ni‐Ti prostate stent as a fiducial marker. The comparison included computing translational and rotational differences between the approaches, visual inspection, and computing the overlap of the CTV. The computed mean translational difference was 1.65, 1.60, and 1.80 mm and the computed mean rotational difference was 1.51°, 3.93°, and 2.09° in the superior/inferior, anterior/posterior, and medial/lateral direction, respectively. The sensitivity of overlap was 87%. The results demonstrate that the automatic registration approach performs registrations comparable to the manual registration.PACS number(s): 87.57.nj, 87.61.‐c, 87.57.Q‐, 87.56.J‐

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Section: Introductionmentioning

confidence: 99%

“…This assumption has been investigated and discussed in a number of studies 15 , 16 , 17 , 18 , 19 . Kerkhof et al (15) investigated the prostate deformation based on manual prostate delineations in MR scans.…”

Section: Introductionmentioning

confidence: 99%

Comparison of manual and automatic MR‐CT registration for radiotherapy of prostate cancer

Korsager

Carl

Østergaard

2016

J Applied Clin Med Phys

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“…Some centers prefer to include all of the SV in the CTV while some of them includes the proximal 2.0 cm of the SV. [15][16] Currently, interfraction displacement of the prostate and SV is demonstrated with various IGRT methods. Some authors noted that the SV move independently from the prostate and more than the prostate and they suggested to give larger margins.…”

Section: Discussionmentioning

confidence: 99%

“…[8][9] In the literature, the prostate motion has been well described while SV motion and dosimetric analysis have been relatively less well reported. [10][11][12][13][14][15][16][17][18] When the SV are included in the target volume, independent motion and the rotation of the SV and prostate may affect the dose distribution of the SV in prostate based image guidance. Stenmark et al showed that the displacement of the SV was different from the prostate and this movement was more in the distal part rather than the proximal part of SV.…”

Section: Introductionmentioning

confidence: 99%

“…18 Although the majority of the studies analyzed the inter-or intrafraction displacements of the SV and the planning target volume (PTV) margins, there is little data about the cumulative dose distribution of SV throughout the treatment. [15][16][17][18] In this study is aimed to validate the actual doses delivered to the seminal vesicle depending on the organ movement by IGRT methods.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of Interfractional Movement of the Seminal Vesicle and Dose Variations with IGRT Throughout the Prostate Cancer Radiotherapy.

Ergen¹

2016

UHOD

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To validate the actual cumulative doses delivered to the seminal vesicle (SV) depending on the organ movement using kV-Cone Beam CT (kV-CBCT) datasets acquired during prostate image-guided radiation therapy. Ten patients with intermediate risk prostate cancer treated with IMRT were included in this study. Both the prostate and the first 2 cm of the SV were included in the CTV. PTV margin was 8 mm in all directions except posterior, where it was 5 mm. Sixteen kV-CBCT scans per patient were used for assessments. After each kV-CBCT was matched with the planning CT based on prostate, the SV were recontoured as proximal, distal SV and both of them together (the whole SV). Actual delivered doses to the SV were assessed by means of DVH. The variations in certain dosevolume parameters were analyzed using the Student's test. Systematic and random errors of the SV and margins were assessed using the van-Herk formula. We observed that the SV movement in the anterior-posterior direction was significantly more compared to superior-inferior and left-right direction. The dose volume variations for the whole SV (D98%, D50%, D2%) and the distal SV (D98%, D95%, D50%) were significantly different than the planned doses. However, both the whole SV and the distal SV received the prescribed dose. Although it seems that there is a need to give larger margin to the SV in posterior direction, the actual cumulative doses delivered to SV throughout the treatment were within the prescribed dose.Keywords: Image guided radiation therapy, Interfraction motions, kV-CBCT, Prostate cancer, Seminal vesicle ÖZET Prostat kanseri Radyoterapisi Sırasında Fraksiyonlar Arası Seminal Vezikül Hareketleri ve Doz Değişimlerinin IGRT ile DeğerlendirilmesiBu çalışmanın amacı, kV-Cone Beam CT (kV-CBCT) ile görüntü kılavuzluğunda prostat kanseri radyoterapisinde organ hareketine bağlı olarak seminal veziküllerin aldığı kümülatif dozların doğruluğunun değerlendirilmesidir. Çalışmamıza IMRT tekniği ile tedavi edilmiş orta risk prostat kanserli on hasta dahil edilmiştir. Prostat ve seminal vesiküllerin ilk 2 cm'lik bölümü CTV'ye dahil edilmiştir. Prostat ve SV'e posterior yönden 5 mm, diğer yönlerden 8 mm PTV marjı verilmiştir. Her hastadan 16 kV-CBCT alınmış ve SV'ye verilen marjın yeterli olup olmadığını saptamak için seçilen kV-CBCT görüntüleri ile planlama BT görüntüleri prostat referans alınarak offline eşleştirilmiştir. Seminal veziküller, proksimal-distal SV şeklinde ayrı ayrı ve her ikisi birlikte tüm SV olacak şekilde yeniden konturlanmıştır. Seminal veziküllerin aldığı doz DVH yardımı ile değerlendirilmiştir. Doz volüm histogramındaki değişiklikler Student test ile analiz edilmiştir. Sistematik ve random hatalar van-Herk formülü ile değerlendirilerek gerekli emniyet marjları bulunmuştur. Seminal vezikül hareketinin alt-üst ve sağ-sol yöne kıyasla ön-arka eksende daha fazla olduğu görülmüştür. Tüm SV için (D98% D50,% D2%) ve distal SV için doz volüm değişiklikleri (D98% D95,% D50%) planlanan dozlardan önemli ölçüde farklı bulunmuştur. Bununla bir...

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Usefulness of hybrid deformable image registration algorithms in prostate radiation therapy

Motegi

Tachibana

Motegi

et al. 2018

J Applied Clin Med Phys

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To evaluate the accuracy of commercially available hybrid deformable image registration (DIR) algorithms when using planning CT (pCT) and daily cone‐beam computed tomography (CBCT) in radiation therapy for prostate cancer. The hybrid DIR algorithms in RayStation and MIM Maestro were evaluated. Contours of the prostate, bladder, rectum, and seminal vesicles (SVs) were used as region‐of‐interest (ROIs) to guide image deformation in the hybrid DIR and to compare the DIR accuracy. To evaluate robustness of the hybrid DIR for prostate cancer patients with organs with volume that vary on a daily basis, such as the bladder and rectum, the DIR algorithms were performed on ten pairs of CT volumes from ten patients who underwent prostate intensity‐modulated radiation therapy or volumetric modulated arc therapy. In a visual evaluation, MIM caused unrealistic image deformation in soft tissues, organs, and pelvic bones. The mean dice similarity coefficient (DSC) ranged from 0.46 to 0.90 for the prostate, bladder, rectum, and SVs; the SVs had the lowest DSC. Target registration error (TRE) at the centroid of the ROIs was about 2 mm for the prostate and bladder, and about 6 mm for the rectum and SVs. RayStation did not cause unrealistic image deformation, and could maintain the shape of pelvic bones in most cases. The mean DSC and TRE at the centroid of the ROIs were about 0.9 and within 5 mm generally. In both software programs, the use of ROIs to guide image deformation had the possibility to reduce any unrealistic image deformation and might be effective to keep the DIR physically reasonable. The pCT/CBCT DIR for the prostate cancer did not reduce the DIR accuracy because of the use of ROIs to guide the image deformation.

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Margin Evaluation in the Presence of Deformation, Rotation, and Translation in Prostate and Entire Seminal Vesicle Irradiation With Daily Marker-Based Setup Corrections

Cited by 51 publications

References 22 publications

Comparison of manual and automatic MR‐CT registration for radiotherapy of prostate cancer

Comparison of manual and automatic MR‐CT registration for radiotherapy of prostate cancer

Evaluation of Interfractional Movement of the Seminal Vesicle and Dose Variations with IGRT Throughout the Prostate Cancer Radiotherapy.

Usefulness of hybrid deformable image registration algorithms in prostate radiation therapy

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