Marginal Bone Loss of Dental Implants in Patients with Type 2 Diabetes Mellitus with Poorly Controlled HbA1c Values: A Long-Term Retrospective Study

Lorean, Adi; Ziv-On, Hila; Perlis, Vladimir; Ormianer, Zeev

doi:10.11607/jomi.8476

Cited by 11 publications

(10 citation statements)

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“…A recent retrospective study of 357 implants in 38 PC diabetic (HbA1c 6.9% to 10%) patients with a mean follow-up time of 7.3 years reported a 98.4% survival rate. 49 Future research efforts should implement prospective study designs that collect long-term data regarding clinical survival and success rates of dental implants, as well as dPROs in PC diabetic patients.…”

Section: Discussionmentioning

confidence: 99%

“…Existing long‐term data on implant performance in diabetic patients is minimal, however poor glycemic control over an extended period of time may not diminish long‐term implant survival. A recent retrospective study of 357 implants in 38 PC diabetic (HbA1c 6.9% to 10%) patients with a mean follow‐up time of 7.3 years reported a 98.4% survival rate 49 . Future research efforts should implement prospective study designs that collect long‐term data regarding clinical survival and success rates of dental implants, as well as dPROs in PC diabetic patients.…”

Section: Discussionmentioning

confidence: 99%

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Clinical performance of hydrophilic, titanium‐zirconium dental implants in patients with well‐controlled and poorly controlled type 2 diabetes: One‐year results of a dual‐center cohort study

Latimer,

Roll,

Daubert

et al. 2022

Journal of Periodontology

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Background This study assessed the clinical performance of hydrophilic dental implants in a patient cohort with type 2 diabetes mellitus (T2DM). Methods Subjects with T2DM of ≥2‐years duration were allocated to either the well‐controlled (WC; HbA1c ≤ 7.0%,) or poorly‐controlled (PC; 7.5 < HbA1c < 10%) groups in a dual‐center, prospective cohort study. Each subject received a single, titanium‐zirconium (Ti‐Zr) dental implant with a chemically‐modified, hydrophilic (modSLA) surface in a posterior mandibular site. Postoperatively, subjects were followed at 1, 2, 4, 8, and 12‐week intervals. Post‐loading, subjects were followed at 3, 6, and 12‐months. Clinical and radiographic parameters of implant success, and dental patient‐reported outcomes were collected. Results Twenty‐one dental patients (NWC = 11; NPC = 10; mean age: 66.8 ± 7.5 years) were enrolled and the 1‐year implant success rate was 100%. Peri‐implant bone levels were stable with 0.15 ± 0.06 mm mean marginal loss at 1 year without significant inter‐group differences (P = 0.79). Postoperative pain was minimal at 1‐week, and OHIP‐5 scores decreased significantly over time as compared with preoperative levels (P < 0.001) suggesting significant improvement in patient‐perceived oral health following implant therapy. Conclusions Elevated HbA1c levels > 7.5% did not compromise 1‐year success rates, or oral health‐related quality of life in PC patients receiving modSLA, Ti‐Zr implants. Given that implant placement up to 10% HbA1c significantly enhanced oral health‐related quality of life without complications or morbidity, the safety and efficacy of implants to improve oral function in T2DM is supported, even without ideal glycemic control.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Clinical performance of hydrophilic, titanium‐zirconium dental implants in patients with well‐controlled and poorly controlled type 2 diabetes: One‐year results of a dual‐center cohort study

Latimer,

Roll,

Daubert

et al. 2022

Journal of Periodontology

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“…Examples of individual longitudinal studies yield more recent results that support hyperglycemia as a risk driver. A retrospective chart study encompassing 357 implants placed in an oral surgeon's office reported that patients with uncontrolled type 2 diabetes (T2D) defined as glycated hemoglobin A1c (HbA1c) levels of 8.1%–10.0% had marginal bone loss of 2.33 (±2.85) mm on average versus 1.86 (±2.21) mm in those with HbA1c levels of 6.1%–8.0% 93 . During up to 22 years of follow‐up of 4247 patients with 10 871 implants placed by a single periodontist, diabetes was found to more than double the risk for implant failure (removal for any reason) (HR = 2.25; 05% CI: 1.04–4.89; p = 0.040) 94 .…”

Section: Impact Of Systemic Driversmentioning

confidence: 99%

“…A retrospective chart study encompassing 357 implants placed in an oral surgeon's office reported that patients with uncontrolled type 2 diabetes (T2D) defined as glycated hemoglobin A1c (HbA1c) levels of 8.1%-10.0% had marginal bone loss of 2.33 (±2.85) mm on average versus 1.86 (±2.21) mm in those with HbA1c levels of 6.1%-8.0%. 93 During up to 22 years of follow-up of 4247 patients with 10 871 implants placed by a single periodontist, diabetes was found to more than double the risk for implant failure (removal for any reason) (HR = 2.25; 05% CI: 1.04-4.89; p = 0.040). 94 Among medically compromised patients, only diabetes was associated with greater rate of implant failure defined as marginal bone loss >1 mm the first and >0.3 mm each of the following years after ≥5 years of function.…”

Section: Evidencementioning

confidence: 99%

Impact of local predisposing/precipitating factors and systemic drivers on peri‐implant diseases

Monje

Kan

Borgnakke

2022

Clin Implant Dent Rel Res

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Background Strong evidence suggests the infectious nature of peri‐implant diseases occurring in susceptible hosts. Epidemiological reports, though, indicate that peri‐implantitis is a site‐specific entity. Hence, the significance of local factors that may predispose/precipitate plaque accumulation and the impact of systemic drivers that alter the immune response are relevant in the prevention and management of peri‐implant disorders. Purpose The purpose of the present review is to shed light on the significance of local and systemic factors on peri‐implant diseases, making special emphasis on the associations with peri‐implantitis. Methods The biologic plausibility and supporting evidence aiming at providing a concluding remark were explored in the recent scientific literature for local predisposing/precipitating factors and systemic drivers related to peri‐implant diseases. Results Local predisposing factors such as soft tissue characteristics, implant position and prosthetic design proved being strongly associated with the occurrence of peri‐implant diseases. Hard tissue characteristics, however, failed to demonstrate having a direct association with peri‐implant diseases. Robust data points toward the strong link between residual sub‐mucosal cement and peri‐implant diseases, while limited data suggests the impact of residual sub‐mucosal floss and peri‐implantitis. Systemic drivers/habits such as hyperglycemia and smoking showed a strong negative impact on peri‐implantitis. However, there is insufficient evidence to claim for any link between metabolic syndrome, atherosclerotic cardiovascular disease, and obesity and peri‐implant diseases. Conclusion Local predisposing/precipitating factors and systemic drivers may increase the risk of peri‐implant diseases. Therefore, comprehensive anamnesis of the patients, educational/motivational programs and exhaustive prosthetically‐driven treatment planning must be fostered aiming at reducing the rate of biological complications in implant dentistry.

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“…In fact a recent retrospective study performed by Lorean et al (2021) with a follow-up period of five to seven years concludes that patients with elevated values of glycosylated hemoglobin (HbA1c) (8.1% to 10.0%) had greater marginal bone loss than those with lower HbA1c values, recommending the use of removable prostheses in patients with poor glycemic control [24].…”

Section: Introductionmentioning

confidence: 99%

From Bench to Bedside in Precision Medicine: Diabetes Mellitus and Peri-Implantitis Clinical Indices with a Short-Term Follow-Up: A Systematic Review and Meta-Analysis

Dioguardi

Cantore

Scacco

et al. 2022

JPM

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Background and objective: Diabetes mellitus (DM) refers to a group of metabolic disorders characterized by hyperglycemia resulting from impaired secretion or action of insulin. The high levels of glucose in the blood can negatively affect the healing processes through alterations in vascularization, bone remodeling, and with increased susceptibility to infections. Diabetes mellitus is therefore a risk factor not only for many systemic diseases, but also for localized problems such as peri-implantitis. The objective of this systematic review was to identify a clear relationship between peri-implant inflammation indices and glycemic levels, through the investigation of prospective studies that report data on a short-term follow-up period. Our hypothesis was that peri-implant inflammatory indices may already present themselves in a statistically significant way as altered in patients with DM compared to patients without DM. Materials and methods: This review was reported according to the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA). Results: More than 992 records were identified in the PubMed, Scopus, and Cochrane Central Register of Controlled Trial electronic databases and only seven studies were included in the meta-analysis. The results of the meta-analysis report worse outcomes in patients with DM, even in the short period of six months, for peri-implatitis inflammation indices, such as Marginal bone loss (standardized (Std). mean difference (MD) 12\6 months 0.81 [0.45, 1.17]\1.82 [0.53, 3.10]), Bleeding on probing (Std. MD 12\6 months 2.84 [1.34, 4.34]\3.44 [1.41, 5.50]), Probing depth (Std. MD 12\6 months 1.14 [0.60, 1.68]\2.24 [0.66, 3.83]), and the plaque index (Std. MD 12 months 2.83 [0.09, 5.57]). Conclusion: The literature linking glycaemic control to peri-implant disease is highly heterogeneous due to lack of consistency of the definition of peri-implantitis and its clinical indicators among studies. Therefore, interpretation of finding and relevance to clinical practice should be considered on individual bases. In the era of personalized medicine, the clinician should utilize individualized information from translational researches and analyze all risk factors to provide the patient with evidence-based treatment options.

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Marginal Bone Loss of Dental Implants in Patients with Type 2 Diabetes Mellitus with Poorly Controlled HbA1c Values: A Long-Term Retrospective Study

Cited by 11 publications

References 0 publications

Clinical performance of hydrophilic, titanium‐zirconium dental implants in patients with well‐controlled and poorly controlled type 2 diabetes: One‐year results of a dual‐center cohort study

Clinical performance of hydrophilic, titanium‐zirconium dental implants in patients with well‐controlled and poorly controlled type 2 diabetes: One‐year results of a dual‐center cohort study

Impact of local predisposing/precipitating factors and systemic drivers on peri‐implant diseases

From Bench to Bedside in Precision Medicine: Diabetes Mellitus and Peri-Implantitis Clinical Indices with a Short-Term Follow-Up: A Systematic Review and Meta-Analysis

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