“Marginal keratitis following COVID 19 vaccination”

Farrell, Daniel A.; Deacon, Sara; Mauger, Thomas F.

doi:10.1016/j.idcr.2022.e01536

Cited by 4 publications

(4 citation statements)

References 8 publications

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“…Marginal keratitis as a post-COVID-19 vaccine complication was also reported in one case of our review by Farrell et al [22]. Approximately 2.5 weeks after receiving the mRNA-1273 vaccine's initial dosage, a 68-year-old woman complained of increased right eye pain and redness.…”

Section: Discussionsupporting

confidence: 71%

Ocular Complications after COVID-19 Vaccination: A Systematic Review

Hurissi,

Abuallut,

Dibaji

et al. 2024

Medicina

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Background and Objectives: The COVID-19 pandemic affects various populations worldwide. The discovery of vaccinations was necessary for the prevention and elimination of the disease. Despite the high importance of these vaccinations, they may cause some complications, such as ocular complications. This study aims to draw attention to the possible complications of the vaccination and highlight its importance. Materials and Methods: Systematic review of the literature from January 2021 to January 2023. A total of 20 published articles were included and reported cases of ocular complications in patients who received COVID-19 vaccines. Results: A total of 243 patients with verified ocular complications following the COVID-19 vaccination were included, ranging in age from 18 to 84 years. The most common ocular complications reported in the current study were ocular inflammatory complications, which represented 47.3%, followed by optic neuritis (24.3%). Retinal artery occlusion, retinal vein occlusion, acute macular neuroretinopathy, and paracentral acute middle maculopathy represented 10.7%. Herpetic ocular infections and herpetic eye disease (14%). Nearly half (42%) of the patients with ocular problems received the Pfizer-BioNTech vaccination. Conclusions: Despite the high importance of the COVID-19 vaccination, it was found that it is associated with the occurrence of some ocular complications. Future projects should come with more extensive prospective studies to further elucidate the underlying mechanisms and risk factors associated with ocular complications following COVID-19 vaccination, thereby enhancing our understanding and guiding appropriate management strategies.

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Section: Discussionsupporting

confidence: 71%

Ocular Complications after COVID-19 Vaccination: A Systematic Review

Hurissi,

Abuallut,

Dibaji

et al. 2024

Medicina

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“…Similarly, the pathophysiology of corneal manifestations associated with COVID-19 vaccination is not well understood. Farrell et al 5 have posited that formation of corneal opacities in a case of COVID-19 vaccination-related marginal keratitis may be attributed to a localized type III hypersensitivity reaction, whereby deposits of antigen–antibody immune complexes accumulate in corneal tissue. This theory is supported by research showing presence of corneal ACE-2 receptors, which are the primary target of the SARS-CoV-2 surface spike proteins.…”

Section: Discussionmentioning

confidence: 99%

“…These include herpes simplex virus (HSV) and varicella zoster virus keratouveitis, subepithelial infiltrates in the context of previous epidemic keratoconjunctivitis, corneal graft rejection, corneal epithelial rejection after limbal stem cell transplantation, peripheral ulcerative keratitis, marginal keratitis, and immune-mediated keratolysis. [5][6][7] Onset of symptoms for these immune-related adverse events seems to begin 10 days after vaccination, on average. 7 The most commonly reported corneal events are corneal graft rejections, followed by herpes zoster ophthalmicus.…”

mentioning

confidence: 99%

Rare Case of Thygeson Superficial Punctate Keratitis After COVID-19 Vaccination

Hutchinson

Peretz

Darvish

et al. 2023

Cornea

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Purpose: The aim of this study was to elucidate a rare corneal association of the coronavirus disease 2019 (COVID-19) vaccine. Although cases of corneal involvement after vaccination have been reported, we present the first case of Thygeson superficial punctate keratitis (TSPK) linked to the COVID-19 vaccine. Methods: This study is a case report. Results: A 25-year-old woman was assessed in the ophthalmology clinic for recurrent ocular surface symptoms after receiving the COVID-19 vaccine. She was followed in clinic and was found to have a remitting and recurring pattern of bilateral intraepithelial corneal opacities with associated subepithelial haze primarily overlying the pupillary area. These corneal lesions responded well to topical corticosteroid ophthalmic drops. Based on the clinical appearance, the response to treatment, negative herpes simplex virus serology, and the temporal relationship between vaccination and ocular findings, a diagnosis of COVID-19 vaccine-induced TSPK was suspected. Conclusions: Although the COVID-19 vaccine remains overwhelmingly safe, clinicians should be aware of possible corneal side effects, including TSPK. Prompt ophthalmic assessment in those presenting with ocular symptoms after vaccination is encouraged.

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“…Marginal keratitis as an adverse effect was reported in one case by Farrell et al [ 58 ]. A 66-year-old female presented with worsening right eye pain and redness 2.5 weeks after receiving the first dose of the mRNA-1273 vaccine.…”

Section: Othersmentioning

confidence: 99%

Corneal Adverse Events Associated with SARS-CoV-2/COVID-19 Vaccination: A Systematic Review

et al. 2023

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Vaccines against coronavirus disease 2019 (COVID-19) have played an important global role in reducing morbidity and mortality from COVID-19 infection. While the benefits of vaccination greatly outweigh the risks, adverse events do occur. Non-ocular adverse effects of the vaccines have been well-documented, but descriptions of ophthalmic effects remain limited. This systematic review aims to provide an overview of reported cases of corneal adverse events after receiving vaccination against COVID-19 and to compile existing clinical data to bring attention to these phenomena. Our review discusses corneal graft rejection, including proposed mechanisms, herpetic keratitis, and other reported corneal complications. Ophthalmologists and primary care physicians should be aware of such possible associations.

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“Marginal keratitis following COVID 19 vaccination”

Cited by 4 publications

References 8 publications

Ocular Complications after COVID-19 Vaccination: A Systematic Review

Ocular Complications after COVID-19 Vaccination: A Systematic Review

Rare Case of Thygeson Superficial Punctate Keratitis After COVID-19 Vaccination

Corneal Adverse Events Associated with SARS-CoV-2/COVID-19 Vaccination: A Systematic Review

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