Marginal zone lymphoma of palatine tonsil with prominent plasmacytic differentiation

Ma, Shuang; Jug, Rachel; Shen, Shuai; Zhang, Wanlin; Xu, Hong‐Tao; Yang, Lianhe

doi:10.1097/md.0000000000009648

Cited by 6 publications

(3 citation statements)

References 24 publications

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“…Symptoms may be acute and distressing in high-grade lymphomas. Low-grade variants such as small lymphocytic lymphoma can manifest as obstructive sleep apnoea or with a short history of only odynophagia (6,7); lingual tonsil hypertrophy and indolent lymphoplasmacytic lymphoma associated with amyloidosis can also present with such symptoms (8,9). The clinical features of dysphagia & odynophagia (72%), cervical lymph node enlargement (60%), and otalgia (7%) noted by Mohammadianpanah (4), were recorded in the present study as well.…”

Section: Discussionsupporting

confidence: 75%

Lymphomas of palatine tonsil in patients at a tertiary care centre in coastal India: A ten-year case analysis

Khadilkar¹,

Dosemane²,

Mithra³

et al. 2022

Biomedicine

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Introduction and Aim: Head and neck is affected in 11-33% of extra-nodal Non-Hodgkin Lymphomas with the Waldeyer’s ring comprising 50% and among which palatine tonsils are most commonly involved. Materials and Methods: A retrospective analysis was performed using medical case files to study the demographic and clinical details of 13 patients diagnosed with primary lymphoma of palatine tonsil between 2011 and 2020 at a tertiary care hospital in coastal India. Results: Mean age was 49.7 years with a male preponderance. The usual presentation was either as a unilateral palatine mass or neck swelling with dysphagia, odynophagia and otalgia. All patients had high-grade lymphoma, diffuse large B-cell lymphoma was the commonest type. B-symptoms were seen more often in B-cell lymphoma; stage I was the most frequent. Stage at diagnosis was statistically significant when compared with B-symptoms, bulky disease and International Prognostic Index (IPI) (p-values of 0.02, 0.02 and 0.035 respectively). Overall survival (OS) rate was 44.44%, being higher in females than in males. Higher OS rate was noted for IPI of 1 & 2, and early stage lymphoma, unilateral tonsillar enlargement, normal lactate dehydrogenase, and European Cooperative Oncology Group score of 0. Combined chemoradiation proved to be better (50% OS) than chemotherapy (33.33% OS) alone. Conclusion: Lymphoma must be suspected in unilateral or bilateral asymmetrical tonsillar enlargement, especially in the older age group. Histopathology with immunohistochemistry plays a crucial role in diagnosis and typing of lymphoma, for proper and early institution of treatment with chemoradiation.

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Section: Discussionsupporting

confidence: 75%

Lymphomas of palatine tonsil in patients at a tertiary care centre in coastal India: A ten-year case analysis

Khadilkar¹,

Dosemane²,

Mithra³

et al. 2022

Biomedicine

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“…For instance, ITCH controls the stability of critical immune system proteins 41 and acts upstream of B-cell lymphoma 6 (Bcl-6), the main transcription factor involved in coordinating follicular helper T-cell differentiation and immunoglobulin G (IgG) in response to acute viral infections 42 ; WWP2 negatively regulates Toll-like receptor 3 (TLR3)-mediated innate immune response by targeting TIR-domain containing adapter-inducing interferon-β (TRIF) for ubiquitination and degradation 43 . The innate immune system acts as first responder for the detection and clearance of viral infections.…”

Section: Discussionmentioning

confidence: 99%

Inhibition of HECT E3 ligases as potential therapy for COVID-19

et al. 2021

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SARS-CoV-2 is responsible for the ongoing world-wide pandemic which has already taken more than two million lives. Effective treatments are urgently needed. The enzymatic activity of the HECT-E3 ligase family members has been implicated in the cell egression phase of deadly RNA viruses such as Ebola through direct interaction of its VP40 Protein. Here we report that HECT-E3 ligase family members such as NEDD4 and WWP1 interact with and ubiquitylate the SARS-CoV-2 Spike protein. Furthermore, we find that HECT family members are overexpressed in primary samples derived from COVID-19 infected patients and COVID-19 mouse models. Importantly, rare germline activating variants in the NEDD4 and WWP1 genes are associated with severe COVID-19 cases. Critically, I3C, a natural NEDD4 and WWP1 inhibitor from Brassicaceae, displays potent antiviral effects and inhibits viral egression. In conclusion, we identify the HECT family members of E3 ligases as likely novel biomarkers for COVID-19, as well as new potential targets of therapeutic strategy easily testable in clinical trials in view of the established well-tolerated nature of the Brassicaceae natural compounds.

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“…39 This is consistent with existing literature finding MALT lymphomas within the oropharynx to have the highest survival rates compared to other B-cell and T-cell subtypes, perhaps due to its favorable response to radiation therapy. 19,40 Not surprisingly, T-/ NK-cell and NOS/diffuse malignant lymphomas were associated with significantly lower OS compared to other histologies. T-cell and mixed lymphomas are known to have a poorer prognosis compared to those of B-cell origin due to the former's often more aggressive behavior, 41,42 which our findings confirm.…”

Section: Histologic Subtypementioning

confidence: 99%

Epidemiology and Prognostic Indicators of Survival in Tongue Lymphoma

Hong

Simpson

et al. 2022

Ann Otol Rhinol Laryngol

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Objectives: Lymphoma, categorized as either non-Hodgkin’s lymphoma or Hodgkin’s lymphoma, is the second most common malignancy in the head and neck. Primary tongue lymphoma is exceedingly rare, with only case reports or small case series in the literature. This population-based analysis is the first to report the epidemiology and prognostic factors of survival in patients with primary tongue lymphoma. Methods: The Surveillance, Epidemiology, and End Results 18 database from the National Cancer Institute was queried for patients diagnosed between the years 2000 and 2016 with tongue lymphoma. Outcomes of interest were overall and disease-specific survival. Independent variables included age at diagnosis, sex, race, marital status, primary subsite, histologic subtype, stage, and treatment type. Results and Conclusion: Seven hundred forty patients met criteria; the male-female ratio was 1.5:1 and the mean age at diagnosis was 67.8 years. The majority of lesions localized to the base of tongue (90.0%), were histologically diffuse large B-cell lymphoma (59.5%), and presented at stage I or II (77.9%). Most early-stage lymphomas were treated with chemotherapy only (40.5%) or a combination of both chemotherapy and radiation (31.3%), while late-stage cancers were primarily treated with chemotherapy alone (68.5%). In multivariate analysis, younger age at diagnosis, female sex, married/partnered marital status, mucosa-associated lymphoid tissue histologic subtype, and earlier cancer stage were found to be associated with improved survival. Chemotherapy treatment with or without radiation was also associated with better survival compared to no treatment or radiation alone, though data regarding immunotherapy was unavailable.

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Marginal zone lymphoma of palatine tonsil with prominent plasmacytic differentiation

Cited by 6 publications

References 24 publications

Lymphomas of palatine tonsil in patients at a tertiary care centre in coastal India: A ten-year case analysis

Lymphomas of palatine tonsil in patients at a tertiary care centre in coastal India: A ten-year case analysis

Inhibition of HECT E3 ligases as potential therapy for COVID-19

Epidemiology and Prognostic Indicators of Survival in Tongue Lymphoma

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