Marginal zone lymphoma of the breast—A diminished role for surgery

Koganti, Suman B; Lozada, Alejandra; Curras, Ernesto; Shah, Ajay

doi:10.1016/j.ijscr.2016.05.041

Cited by 11 publications

(9 citation statements)

References 8 publications

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“…Usually, the neoplasm presents itself as a large unilateral and painless mass, rarely bilateral, and with an average size of 3 cm 9,10 . Considering the clinical characteristics, the patient remains in accordance with the literature, being asymptomatic, including without presenting the classic B symptoms -systemic symptoms of fever, night sweat, and unexplained loss of more than 10% of weight in six months -, being the tumor identified as an incidental finding in imaging tests 1,9,10 .…”

Section: Discussionsupporting

confidence: 56%

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Primary breast MALT lymphoma: a case report

Paffer¹,

Coimbra

Souza

et al. 2021

Mastology

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A 42-year-old woman, with no history of autoimmune diseases or risk factors for cancer, sought a private medical clinic for undergoing breast imaging tests, noticing the presence of a solid nodule with indistinct margins — BI-RADS 4 — in the left breast. An ultrasound-guided core biopsy was performed and complemented by histopathological and immunohistochemical studies, confirming the diagnosis of primary small B-cell MALT lymphoma. After treatment with radiotherapy, the patient evolved with remission, maintaining annual follow-up with a specialist physician. The importance of routine screening for pathologies that affect the breasts is highlighted, aiming at their early diagnosis. In addition, radiotherapy has good prognostic results at the expense of surgical treatment.

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Section: Discussionsupporting

confidence: 56%

“…Currently, there is no consensus in the literature regarding the best generalized therapeutic approach, as each case will depend on the biological behavior and histological characteristics of each lymphoma of the patients 9,10 .…”

Section: Discussionmentioning

confidence: 99%

Primary breast MALT lymphoma: a case report

Paffer¹,

Coimbra

Souza

et al. 2021

Mastology

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“…Primary breast lymphomas (PBL) represent approximately 1% of all NHLs, 1.7-2.2% of all extranodal NHLs and 0.04-0.5% of all malignancies of the breast. [18][19][20][21] Around 9% of all primary breast lymphomas are MZLs of MALT and usually manifest an indolent clinical behavior [21][22][23]. The immunohistochemical stain for Ki67 shows a very low proliferative index, pointing at an "indolent" lymphoma ((D): original magnification 100×).…”

Section: Discussionmentioning

confidence: 99%

Primary Breast Extranodal Marginal Zone Lymphoma in Primary Sjögren Syndrome: Case Presentation and Relevant Literature

Ingravallo

Maiorano

Moschetta

et al. 2020

JCM

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The association between autoimmune diseases, mostly rheumatoid arthritis, systemic lupus erythematosus, celiac disease and Sjögren syndrome, and lymphoma, has been widely demonstrated by several epidemiologic studies. By a mechanism which has not yet been entirely elucidated, chronic activation/stimulation of the immune system, along with the administration of specific treatments, may lead to the onset of different types of lymphoma in such patients. Specifically, patients affected by Sjögren syndrome may develop lymphomas many years after the original diagnosis. Several epidemiologic, hematologic, and histological features may anticipate the progression from Sjögren syndrome into lymphoma but, to the best of our knowledge, a definite pathogenetic mechanism for such progression is still missing. In fact, while the association between Sjögren syndrome and non-Hodgkin lymphoma, mostly extranodal marginal zone lymphomas and, less often, diffuse large B-cell, is well established, many other variables, such as time of onset, gender predilection, sites of occurrence, subtype of lymphoma, and predictive factors, still remain unclear. We report on a rare case of primary breast lymphoma occurring three years after the diagnosis of Sjögren syndrome in a 57-year-old patient. The diagnostic work-up, including radiograms, core needle biopsy, and histological examination, is discussed, along with emerging data from the recent literature, thus highlighting the usefulness of breast surveillance in Sjögren syndrome patients.

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“…Primary breast lymphomas (PBL) represent approximately 1% of all NHL, 1.7-2.2% of all extranodal NHL and 0.04-0.5% of all malignancies of the breast. [20][21][22][23] About 9% of all primary breast lymphomas are MZLs of MALT and usually manifest a classic "indolent" behavior. [23][24][25] It is generally accepted that chronic infection and inflammation (such as SS and Hashimoto thyroiditis, Borrelia Burgdorferi in cutaneous MZL, gastric MALToma in Helicobacter pylori infections, viral-associated lymphomas of HCV, HHV8, EBV and HTLV-1) may play a role in lymphoma development, resulting from the transition from polyclonal B cell activation into monoclonal expansion of B-lymphocytes.…”

Section: Discussionmentioning

confidence: 99%

Primary Breast Extranodal Marginal Zone Lymphoma in Primary Sjögren Syndrome: Case Presentation and Relevant Literature

Ingravallo

Maiorano

Moschetta

et al. 2020

Preprint

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The association between autoimmune diseases, mostly rheumatoid arthritis, systemic lupus erythematous, celiac disease and Sjögren syndrome, and lymphoma has been widely demonstrated by several epidemiologic studies. By a not yet entirely elucidated mechanism, chronic activation/stimulation of the immune system, along with the administration of specific treatments, may lead to persistent stimulation of both of B- and T-cells, and to the onset of different types of lymphoma in such patients. Specifically, patients affected by may develop lymphomas may years after the original diagnosis. Several epidemiologic, hematologic and histological factors may anticipate the progression from Sjögren syndrome into lymphoma but, to the best of our knowledge, a definite pathogenetic mechanism for such progression is still missing. In fact, while the association between Sjögren syndrome and non-Hodgkin lymphoma, mostly diffuse large B-cell and extranodal marginal zone lymphomas is well established, many other variables, such as time of onset, gender predilection, sites of occurrence, subtype of lymphoma and predictive factors still remain unclear. We report on a rare case of primary breast lymphoma occurring three years after the diagnosis of Sjögren syndrome in a 57 y.o. patient. The diagnostic work-up, including radiograms, core needle biopsy and histological examination are discussed, along with emerging data from the recent literature, thus highlighting the usefulness of breast surveillance in Sjögren syndrome patients.

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Marginal zone lymphoma of the breast—A diminished role for surgery

Cited by 11 publications

References 8 publications

Primary breast MALT lymphoma: a case report

Primary breast MALT lymphoma: a case report

Primary Breast Extranodal Marginal Zone Lymphoma in Primary Sjögren Syndrome: Case Presentation and Relevant Literature

Primary Breast Extranodal Marginal Zone Lymphoma in Primary Sjögren Syndrome: Case Presentation and Relevant Literature

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