Marijuana-Produced Changes in Pain Tolerance.
Experienced and Non-Experienced Subjects

Milstein, St.L.; MacCannell, Keith L.; Karr, Gerry; Clark, S. J.

doi:10.1159/000468188

Cited by 36 publications

(19 citation statements)

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“…The presentation follows the suggested format provided in the QUORUM statement 9. Of the 11 excluded trials, three did not use randomised treatment comparisons,10-12 four did not use subjective pain outcomes,13-16 two had studied experimentally induced pain, 17 18 and one was published as a letter19 and one as an abstract 20…”

Section: Resultsmentioning

confidence: 99%

Are cannabinoids an effective and safe treatment option in the management of pain? A qualitative systematic review

Campbell

2001

BMJ

360

199

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Objective To establish whether cannabis is an effective and safe treatment option in the management of pain. Design Systematic review of randomised controlled trials. Data sources Electronic databases Medline, Embase, Oxford Pain Database, and Cochrane Library; references from identified papers; hand searches. Study selection Trials of cannabis given by any route of administration (experimental intervention) with any analgesic or placebo (control intervention) in patients with acute, chronic non-malignant, or cancer pain. Outcomes examined were pain intensity scores, pain relief scores, and adverse effects. Validity of trials was assessed independently with the Oxford score. Data extraction Independent data extraction; discrepancies resolved by consensus. Data synthesis 20 randomised controlled trials were identified, 11 of which were excluded. Of the 9 included trials (222 patients), 5 trials related to cancer pain, 2 to chronic non-malignant pain, and 2 to acute postoperative pain. No randomised controlled trials evaluated cannabis; all tested active substances were cannabinoids. Oral delta-9-tetrahydrocannabinol (THC) 5-20 mg, an oral synthetic nitrogen analogue of THC 1 mg, and intramuscular levonantradol 1.5-3 mg were about as effective as codeine 50-120 mg, and oral benzopyranoperidine 2-4 mg was less effective than codeine 60-120 mg and no better than placebo. Adverse effects, most often psychotropic, were common.

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Section: Resultsmentioning

confidence: 99%

Are cannabinoids an effective and safe treatment option in the management of pain? A qualitative systematic review

Campbell

2001

BMJ

360

199

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“…A few studies to date have explored the effects of smoked marijuana on experimentally induced pain. Smoked marijuana improved pain tolerance in one study . In another study, smoked marijuana decreased pain sensitivity and intensity and improved pain tolerance in pain induced by the cold pressor test, in which the subject places his or her hand in water at a temperature of 4°C .…”

Section: Review Of Potential Medical Uses For Marijuana and Cannabinomentioning

confidence: 94%

Medical marijuana for cancer

Kramer

2014

CA A Cancer J Clinicians

117

101

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Answer questions and earn CME/CNE Marijuana has been used for centuries, and interest in its medicinal properties has been increasing in recent years. Investigations into these medicinal properties has led to the development of cannabinoid pharmaceuticals such as dronabinol, nabilone, and nabiximols. Dronabinol is best studied in the treatment of nausea secondary to cancer chemotherapy and anorexia associated with weight loss in patients with acquired immune deficiency syndrome, and is approved by the US Food and Drug Administration for those indications. Nabilone has been best studied for the treatment of nausea secondary to cancer chemotherapy. There are also limited studies of these drugs for other conditions. Nabiximols is only available in the United States through clinical trials, but is used in Canada and the United Kingdom for the treatment of spasticity secondary to multiple sclerosis and pain. Studies of marijuana have concentrated on nausea, appetite, and pain. This article will review the literature regarding the medical use of marijuana and these cannabinoid pharmaceuticals (with emphasis on indications relevant to oncology), as well as available information regarding adverse effects of marijuana use.

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“…It is generally accepted that smoking cannabis ameliorates the perception of pain in healthy volunteers [39][40][41] . However, it is questionable, whether the effect is of antinociceptive or rather psychotropic nature and possibly both components may play a role 42 .…”

Section: Clinical Experience With Cannabis In Cancer Pain and Multiplmentioning

confidence: 99%

Medical cannabis in the treatment of cancer pain and spastic conditions and options of drug delivery in clinical practice

Landa¹,

Juřica²,

Slíva³

et al. 2018

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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The use of cannabis for medical purposes has been recently legalised in many countries including the Czech Republic. As a result, there is increased interest on the part of physicians and patients in many aspects of its application. This mini review briefly covers the main active substances of the cannabis plant and mechanisms of action. It focuses on two conditions, cancer pain and spasticity in multiple sclerosis, where its effects are well-documented. A comprehensive overview of a few cannabis-based products and the basic pharmacokinetics of marijuana's constituents follows. The review concludes with an outline for preparing cannabis (dried inflorescence) containing drug dosage forms that can be produced in a hospital pharmacy.

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Marijuana-Produced Changes in Pain Tolerance. Experienced and Non-Experienced Subjects

Cited by 36 publications

References 0 publications

Are cannabinoids an effective and safe treatment option in the management of pain? A qualitative systematic review

Are cannabinoids an effective and safe treatment option in the management of pain? A qualitative systematic review

Medical marijuana for cancer

Medical cannabis in the treatment of cancer pain and spastic conditions and options of drug delivery in clinical practice

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