Marijuana Use during Pregnancy and Preterm Birth: A Prospective Cohort Study

Klebanoff, Mark A.; Wilkins, Diana G.; Keim, Sarah A.

doi:10.1055/s-0040-1708802

Cited by 20 publications

(29 citation statements)

References 30 publications

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“…Indeed, the occurrence of preterm birth in LEAF pregnancies is higher than that observed at OSUWMC in general, likely reflecting the clinics where much of the PRR enrolment was done. 19 The high- Nevertheless, others have proposed alternate study designs to address these concerns. One such design is the "negative control, 69 " whereby paternal use during pregnancy or maternal use before pregnancy is compared to maternal use during pregnancy.…”

Section: Limitations Of the Datamentioning

confidence: 99%

“…71,72 Regardless, the PRR did not inquire about maternal prepregnant marijuana use nor are there stored maternal prepregnant urine samples, analysis of which would be necessary to determine such use given the insensitivity of self-report. 19,73 Although fathers in the PRR completed a brief questionnaire, it did not include marijuana use. However, paternal urine was collected for approximately 40% of pregnancies and paternal use might be investigated as a negative control in a future sensitivity analysis, should funding to analyse the urine samples be available.…”

Section: Limitations Of the Datamentioning

confidence: 99%

“…The PRR, a general purpose data and specimen repository, recruited women receiving antenatal care from several clinics at the Ohio State University Wexner Medical Center (OSUWMC), a large academic medical centre (Columbus, Ohio, USA). The PRR and its relationship to LEAF have been previously described 19 . PRR inclusion criteria were age 16‐50 years, ability to communicate in English, and intent to deliver at OSUWMC.…”

Section: Study Populationmentioning

confidence: 99%

“…PRR inclusion criteria were age 16‐50 years, ability to communicate in English, and intent to deliver at OSUWMC. Women who consented completed an intake questionnaire covering a wide variety of medical, demographic, and socio‐economic domains; the questionnaire included items on use of tobacco and a single question on use 19 of marijuana and other drugs of abuse to date during the current pregnancy. Women provided urine and blood samples (coinciding when possible with a clinical blood draw) at enrolment and then in each trimester for unspecified future use, and these were stored at −80°C.…”

Section: Study Populationmentioning

confidence: 99%

“…Data from the neonate's nursery course were also abstracted by trained personnel. The full text of the questionnaire and abstraction form items pertinent to drug use has been published 19 . The PRR consent included an option to allow recontact for participation in future IRB‐approved research, and approximately 75% of PRR enrolled women agreed to this.…”

Section: Study Populationmentioning

confidence: 99%

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Lifestyle and Early Achievement in Families (LEAF) study: Design of an ambidirectional cohort study of prenatal marijuana exposure and child development and behaviour

Klebanoff

Fried

Yeates

et al. 2020

Paediatric Perinatal Epid

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Background: Marijuana is the most-used illicit substance during pregnancy in the USA, but only two cohort studies, begun over 30 years ago, were specifically established to assess the association of pregnancy use with childhood outcomes. They found use to be associated with specific deficits in executive function at 8+ years, but did not focus on these outcomes earlier in life when intervention may be more successful. Two general purpose cohorts found increased aggression in exposed female toddlers and increased behavioural problems and tic disorders in exposed school-age children. Objectives: The Lifestyle and Early Achievement in Families (LEAF) study assesses the association of in utero marijuana exposure, documented prospectively by biomarker, self-report, and medical records, with executive function and aggression at age 3½-7 years. Methods: This ambidirectional cohort (historical cohort with continued follow-up) includes women enrolled in the Perinatal Research Repository during prenatal care at Ohio State University Wexner Medical Center and their children, recontacted 3½-7 years post-birth. Children complete 1-2 study visits including cognitive testing, behavioural observation, and maternal and teacher report of behaviour. Family and social environmental factors are assessed. Results: Child follow-up began in September 2016; visits continue through August 2020. There are 362 eligible children; 32% had mothers who used marijuana during pregnancy, 10% of mothers completed college, and 23% did not complete high school. Mean maternal age at study registration in pregnancy was 26.4 years, and 63% of mothers were African American. To date, 268 children have completed at least 1 study visit. Conclusions: The LEAF Study will document the association of prenatal marijuana exposure with development and behaviour in the current era when marijuana is more potent than when previous cohorts were studied. The results may inform policy and interventions to counsel reproductive-aged women about the risks of use during pregnancy and guide prevention and treatment of adverse effects among children. | 745 KLEBANOFF Et AL. 1 | BACKG ROU N D Marijuana is the most commonly used illicit substance in the USA, and its use is increasing dramatically with state-level legalisation. A recent study examining the prevalence and frequency of cannabis use among pregnant women found large increases between 2002 and 2017, with reports of past month use increasing from 3.4% to 7.0%, and reports of first trimester use increasing from 5.7% to 12.1%. 1 Yet, despite warnings from the American College of Obstetricians and Gynecologists to discontinue prenatal use because of "worri-How to cite this article: Klebanoff MA, Fried P, Yeates KO, et al. Lifestyle and Early Achievement in Families (LEAF) study: Design of an ambidirectional cohort study of prenatal marijuana exposure and child development and behaviour.

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Section: Limitations Of the Datamentioning

confidence: 99%