Marine algal natural products with anti-oxidative, anti-inflammatory, and anti-cancer properties

Lee, Jin‐Ching; Hou, Ming‐Feng; Huang, Hurng Wern; Chang, Fang Rong; Yeh, Ching-Sheng; Tang, Jen Yang; Chang, Hsueh-Wei

doi:10.1186/1475-2867-13-55

Cited by 260 publications

(157 citation statements)

References 108 publications

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“…All 18 extracts exhibited a degree of inhibition of production of the inflammatory mediator NO, whereby the activity followed the order: non-polar extracts > intermediate polarity extracts > polar extracts. Non-polar (DCM) extracts are the FA-rich fraction and also known to contain phenolic compounds as well as pigments; all of which have unique functions in inflammatory metabolism (Jaswir and Monsur 2011;Lee et al 2013). Interestingly, n-3 PUFA have been reported as modulators of the activity of nitric oxide synthase (NOS) (Radosinska et al 2011), one of the primary enzymes involved in NO production.…”

Section: Discussionmentioning

confidence: 99%

Selecting Australian marine macroalgae based on the fatty acid composition and anti-inflammatory activity

et al. 2014

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Increasingly, macroalgae are being recognised as a growth opportunity for functional foods and nutritional security in the future. Dominating traits of interest are metabolites that function as anti-inflammatories and are antiproliferative. However, seaweeds from the northern hemisphere dominate this field of research. Australia has a unique flora of macroalgae, and it is poorly understood which species should be targeted for cultivation towards food and health markets. Here, six Australian marine macroalgae were selected for screening of one anti-inflammatory group; n-3 polyunsaturated fatty acids (PUFA). PUFA profiles were determined using gas chromatography-mass spectrometry and multivariate analysis. Thirty-one fatty acids (FA) were identified across the six macroalgal species with C16:0 the dominant FA in all samples, variations across taxa in the saturated FA C10:0, C14:0, C16:0, C18:0 and C20:0 and variations in monounsaturated FA attributed to C16:1 n-7 and C18:1 n-9. For PUFA profiles, all six species had significantly different n-6/n-3 ratios, while the green seaweed Ulva species possessed the lowest n-6/n-3 ratio of 0.4, along with a 2-fold higher C18:3 n-3 to C18:2 n-6 content. Ulva sp. was the only species that contained docosahexaenoic acid. Extracts of both the Ulva sp. and Hormosira banksii showed selective cytotoxicity towards a human pancreatic cancer cell line, while the nonpolar extracts of all six algae species strongly inhibited production of the inflammatory-mediator nitric oxide. Abstract Increasingly macroalgae are being recognized as a growth opportunity for functional foods and nutritional security in the future. Dominating traits of interest are metabolites that function as anti-inflammatories and are antiproliferative. However seaweeds cultivated in the northern hemisphere dominate this field of research. Australia has a unique flora of macroalgae and it is poorly understood which species should be targeted for cultivation towards food and health markets. Herein, six Australian marine macroalgae were selected for screening of one antiinflammatory group; n-3 polyunsaturated fatty acids (PUFA). PUFA profiles were determined using gas chromatography -mass spectrometry and multivariate analysis. Thirty-one fatty acids (FA) were identified across the six macroalgal species with C16:0 the dominant FA in all samples, variations across taxa in the saturated FA C10:0, C14:0, C16:0, C18:0 and C20:0 and variations in monounsaturated FA attributed to C16:1 n-7 and C18:1 n-9. For PUFA profiles, all six species had significantly different n-6/n-3 ratios, while the green seaweed Ulva sp. possessed the lowest n-6/n-3 ratio of 0.4, along with a 2-fold higher C18:3 n-3 to C18:2 n-6 content. Ulva sp. was the only species that contained docosahexaenoic acid. Extracts of both the Ulva sp. and H. banksii showed selective cytotoxicity towards a human pancreatic cancer cell line, while the non-polar extracts of all six algal species strongly inhibited production of the inflammatory-mediator nitric ...

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Section: Discussionmentioning

confidence: 99%

Selecting Australian marine macroalgae based on the fatty acid composition and anti-inflammatory activity

et al. 2014

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“…Several studies have shown that not only medical plants, but also algae contain beneficial non-nutritive agents such as polyphenols, chlorophylls, and sulfated polysaccharides, which possess antimutagenicity, anticarcinogenicity, and antioxidant activity (Cornish and Garbary, 2010;Lee et al, 2013). We previously demonstrated that the amounts of total phenolic compounds, total carbohydrates, and sulfates of the hot water extract were greater than those of raw materials (Thumvijit et al, 2013b).…”

Section: Discussionmentioning

confidence: 99%

“…Avoiding exposure to either carcinogens or other risk factors can prevent cancer. Moreover, there are numerous reports of naturally occurring substances that inhibit cancer formation; sources of these substances include plants, animals, and microorganisms such as algae (Nobili et al, 2009;Lee et al, 2013;Muthuirulappan et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Cancer Chemopreventive Effect of Spirogyra Neglecta (Hassall) Kützing on Diethylnitrosamine-Induced Hepatocarcinogenesis in Rats

Thumvijit¹,

Taya²,

Punvittayagul³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Spirogyra neglecta, a freshwater green alga, is a local food in the northern and northeastern parts of Thailand. This investigation explored the anticarcinogenicity of S neglecta and its possible cancer chemopreventive mechanisms in rats divided into 14 groups. Groups 1 and 10 served as positive and negative control groups, respectively. Groups 1-9 were intraperitoneally injected with diethylnitrosamine (DEN) once a week for 3 weeks. Groups 10-14 received normal saline instead. One week after the last DEN injection, groups 2-5 were administered for 9 consecutive weeks various doses of S neglecta extract (SNE) and dried S neglecta (SND), mixed with basal diet. Groups 6-9 and 11-14 similarly were administered various doses of SNE and SND starting from the first week of the experiment. Administration of SNE and SND was not associated with formation of glutathione-Stransferase placental form (GST-P) positive foci in rat liver. SNE and SND during initiation phase significantly reduced the number of GST-P positive foci in rats injected with DEN. The number of GST-P also diminished in groups treated with SNE and SND after injection with DEN, except for the low dose extract group. SNE showed stronger anticarcinogenic potency than SND. Furthermore, SNE also decreased the number of Ki-67 positive cells. However, the numbers of TUNEL-positive cells in the liver of the SNE-treated groups were not statistically different from the controls. The GST activity in 50 mg/kg bw of SNE and 1% of SND groups was significantly increased as compared to the positive control. In conclusion, Spirogyra neglecta (Hassall) Kützing showed cancer chemopreventive properties at the early stages of diethylnitrosamine-induced hepatocarcinogenesis in rats. Possible inhibitory mechanisms include enhancement of the activities of some detoxifying enzymes and/or suppression of precancerous cells.

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“…[57]. Another species Sargassum wightii exhibited anti inflammatory effects [58]. Alcoholic extract of S. ilicifilium was tested against five human cancer cell line MCF-7, MDA-MB-231, HeLa, HepG2, HT-29 and the extract shows an anti proliferative effect against all the five cancer cell line in a dose regulated fashion [59].…”

Section: Sargassummentioning

confidence: 99%

“…Dalton's Ascitic lymphoma, HepG2, HT-29, Ca co-2, T47D, MDA-MB468 and /NIH 313, [55][56][57][58][59][60] Stypopodium sp SH-SY5Y, RBL-2H3, (Raw267), (V79), Caco-2. DU-145 [53,62] Undaria sp is one of the important genera under Pheophyceae.…”

Section: Solieriamentioning

confidence: 99%

Algae as potential repository of anti cancerous natural compounds

Mridha¹,

Paul²

2017

ijpm

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Algae constitute a promising source of novel compounds with potential as human therapeutic agents. In particular, algae have been considered as a potential source of new bio-active compound. Algae possess several biological activities, including anticancer activity. This review provides a comprehensive report on the several genera of algae belonging to Chlorophyceae, Pheophyceae and Rhodophyceae having anti-proliferative, apoptotic, anti angiogenic as well as cytotoxic efficacy and their mode of action in vitro as well as in vivo condition. Algae are extensively used as functional foods and medicinal herbs, and have a long history of use in Asian countries. Many algae have been used for the treatment of cancer, many crude or partially purified polysaccharides from various brown, green, and red algae have been tested for their antitumor activities. Relevant information was collected from scientific journals, books, and reports via library and electronic search using Medline, Pubmed, Science Direct, and Scopus. The different extracts with some other solvent shows a huge anti-proliferative action on different cancer as well as on different leukemia cell lines. Here we focus on several bioactive compounds that have been derived as well as characterized from different genera of algae and there mechanism of inhibiting cancer cell growth. Considering the ability of the golden treasure present in algae to act against different cancers, this review highlights the potential use of algae as anticancer agents.

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Marine algal natural products with anti-oxidative, anti-inflammatory, and anti-cancer properties

Cited by 260 publications

References 108 publications

Selecting Australian marine macroalgae based on the fatty acid composition and anti-inflammatory activity

Selecting Australian marine macroalgae based on the fatty acid composition and anti-inflammatory activity

Cancer Chemopreventive Effect of Spirogyra Neglecta (Hassall) Kützing on Diethylnitrosamine-Induced Hepatocarcinogenesis in Rats

Algae as potential repository of anti cancerous natural compounds

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