Marine and Agro-Industrial By-Products Valorization Intended for Topical Formulations in Wound Healing Applications

Prelipcean, Ana-Maria; Iosăgeanu, Andreea; Gaspar‐Pintiliescu, Alexandra; Moldovan, Lucia; Crăciunescu, Oana; Negreanu–Pîrjol, Ticuţa; Mitran, Raul−Augustin; Marin, Mariana; D’Amora, Ugo

doi:10.3390/ma15103507

Cited by 14 publications

(9 citation statements)

References 49 publications

(64 reference statements)

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“…C9185, Merck Group, Darmstadt, Germany, equipped with a Biopack UF cartridge) was used for all experiments. Collagen was provided by the National Institute of Research and Development for Biological Sciences, Bucharest, Romania and prepared as previously described [ 36 ].…”

Section: Methodsmentioning

confidence: 99%

Novel Collagen-Polyphenols-Loaded Silica Composites for Topical Application

et al. 2023

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Lesions can affect skin functions and cause a simple issue, such as dehydration, or more challenging complications, such as bacterial infections. The purpose of this study was to design composites for topical application that can prevent and/or assist in bacterial infections and support cell regeneration using natural components. A polyphenolic extract obtained from Salvia officinalis was embedded in functionalized mesoporous silica nanoparticles for better stability, followed by their distribution into a collagen porous scaffold. The resulting polyphenols-loaded MSN exhibited enhanced antibacterial activity and good cytocompatibility. Improved thermal stability of the collagen porous scaffold was obtained due to the presence of the functionalized MSN. For the first time, collagen-polyphenols-loaded silica composites were reported in the literature as potential wound dressings. The newly developed composites showed excellent sterility.

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Section: Methodsmentioning

confidence: 99%

Novel Collagen-Polyphenols-Loaded Silica Composites for Topical Application

et al. 2023

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“…Sirbu et al obtained marine chitosan polymers gels from Black Sea stone crabs with applications in wound healing [183]. Prelipcean et al used marine collagen topical formulations in wound-healing applications [184].…”

Section: Biological Activities Useful In Wound Healingmentioning

confidence: 99%

Jellyfishes—Significant Marine Resources with Potential in the Wound-Healing Process: A Review

et al. 2023

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The wound-healing process is a significant area of interest in the medical field, and it is influenced by both external and patient-specific factors. The aim of this review paper is to highlight the proven wound-healing potential of the biocompounds found in jellyfish (such as polysaccharide compounds, collagen, collagen peptides and amino acids). There are aspects of the wound-healing process that can benefit from polysaccharides (JSPs) and collagen-based materials, as these materials have been shown to limit exposure to bacteria and promote tissue regeneration. A second demonstrated benefit of jellyfish-derived biocompounds is their immunostimulatory effects on growth factors such as (TNF-α), (IFN-γ) and (TGF), which are involved in wound healing. A third benefit of collagens and polysaccharides (JSP) is their antioxidant action. Aspects related to chronic wound care are specifically addressed, and within this general theme, molecular pathways related to tissue regeneration are explored in depth. Only distinct varieties of jellyfish that are specifically enriched in the biocompounds involved in these pathways and live in European marine habitats are presented. The advantages of jellyfish collagens over mammalian collagens are highlighted by the fact that jellyfish collagens are not considered transmitters of diseases (spongiform encephalopathy) or various allergic reactions. Jellyfish collagen extracts stimulate an immune response in vivo without inducing allergic complications. More studies are needed to explore more varieties of jellyfish that can be exploited for their biocomponents, which may be useful in wound healing.

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“…COL from marine organisms is also an attractive choice, as it is highly abundant in solid marine waste and it has been found in different marine species such as, sponges, corals, salmon, jellyfish, coralline, red algae , sea urchins and mollusks [ 138 , 139 ]. It provides fewer risks of disease transmission and religious restrictions than mammalian COL [ 140 ].…”

Section: Naturally-derived Bioinks For 3d Bioprinting Of Cartilage Ti...mentioning

confidence: 99%

Three-Dimensional Bioprinting for Cartilage Tissue Engineering: Insights into Naturally-Derived Bioinks from Land and Marine Sources

Szychlinska

Bucchieri

Fucarino

et al. 2022

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In regenerative medicine and tissue engineering, the possibility to: (I) customize the shape and size of scaffolds, (II) develop highly mimicked tissues with a precise digital control, (III) manufacture complex structures and (IV) reduce the wastes related to the production process, are the main advantages of additive manufacturing technologies such as three-dimensional (3D) bioprinting. Specifically, this technique, which uses suitable hydrogel-based bioinks, enriched with cells and/or growth factors, has received significant consideration, especially in cartilage tissue engineering (CTE). In this field of interest, it may allow mimicking the complex native zonal hyaline cartilage organization by further enhancing its biological cues. However, there are still some limitations that need to be overcome before 3D bioprinting may be globally used for scaffolds’ development and their clinical translation. One of them is represented by the poor availability of appropriate, biocompatible and eco-friendly biomaterials, which should present a series of specific requirements to be used and transformed into a proper bioink for CTE. In this scenario, considering that, nowadays, the environmental decline is of the highest concerns worldwide, exploring naturally-derived hydrogels has attracted outstanding attention throughout the scientific community. For this reason, a comprehensive review of the naturally-derived hydrogels, commonly employed as bioinks in CTE, was carried out. In particular, the current state of art regarding eco-friendly and natural bioinks’ development for CTE was explored. Overall, this paper gives an overview of 3D bioprinting for CTE to guide future research towards the development of more reliable, customized, eco-friendly and innovative strategies for CTE.

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Marine and Agro-Industrial By-Products Valorization Intended for Topical Formulations in Wound Healing Applications

Cited by 14 publications

References 49 publications

Novel Collagen-Polyphenols-Loaded Silica Composites for Topical Application

Novel Collagen-Polyphenols-Loaded Silica Composites for Topical Application

Jellyfishes—Significant Marine Resources with Potential in the Wound-Healing Process: A Review

Three-Dimensional Bioprinting for Cartilage Tissue Engineering: Insights into Naturally-Derived Bioinks from Land and Marine Sources

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