Marine anti‐corrosion paints based on thiouracil compounds

Abstract

The inhibition of marine corrosion of steel by 6‐amino‐2‐thiouracil (I) and its derivatives 6‐benzylideneamino‐2‐thiouracil (II) and 6‐p‐chlorobenzylideneamino‐2‐thiouracil (III) has been tested on laboratory scale using electrochemical technique which was performed on mild steel in sea water medium and on field scale through the incorporation of the compounds individually in marine paints compositions. The paints containing the compounds were applied on unprimed steel and the coated panels were tested in Alexandria Eastern Harbour water (Egypt). The electrochemical measurements indicated that both compounds (I) and (III) acted as cathodic‐type inhibitors, but the data of compound (II) showed neither cathodic nor anodic inhibition. Two marine paint compositions were prepared using different binder materials. The three compounds were added individually in both paint compositions. The paint composition based on the soluble resin material as a sole binder and containing compound (I) showed the best corrosion protection of its steel surface till more than two months followed by the paint composition containing compound (III). The same paint containing the compounds showed antifouling property for four months.

Effect of the sulfur atom on S2 and S4 positions of the uracil ring in different DNA:RNA hybrid microhelixes with three nucleotide base pairs

“…Although the nucleobases with sulfur appear with the same distribution of acceptors and donors groups that the natural nucleobases with oxygen, however, the thiobases cause specific changes in the properties. Thus, a large number of thiouracil derivatives have been used in numerous pharmacological applications, and also attract attention for anti‐HIV, heart diseases treatments, and others . Nucleosides containing 2‐thiouracil are modified units that appear essentials in natural and synthetic nucleic acids .…”

Accurate molecular structure and spectroscopic properties of nucleobases: a combined computational–microwave investigation of 2-thiouracil as a case study

“…5 For example, 6-n-propyl-2-thiouracil is a potent antithyroid drug, 6 fluorinated-2-thiouracil derivatives show remarkable antitumour 7 and antithyroid 8 activity, 5-cyano-2-thiouracils and their derivatives have considerable interest as potent leishmanicides. 9 A further interest on these compounds is related to their use as marine corrosion inhibitors for steel 10 and as dental adhesive in the treatment with metal surface. 11 Among thiouracils, 2-thiouracil (2TU) is of particular importance for its anticancer and antiviral activity, related to its readily incorporation into nucleic acids, 12 which avoids for instance the melanoma tumor growth.…”

Electrochemical oxidation of 2-thiouracil at pyrolytic graphite electrode

“…The molecular interaction of 2-thiouracil with 7,7,8,8-tetracyanoquinodimethane as an electron acceptor has been reported in the literature [4]. The properties of thiouracils as marine corrosion inhibitors for steel has been well reported [5,6]. 2-Thiouracil has been identified in t-RNA and its chemotherapeutic activity has been explained on the bases of its ready incorporation into the nucleic acid [7].…”