Marine bacterial exopolysaccharide EPS11 inhibits migration and invasion of liver cancer cells by directly targeting collagen I

Liu, Ge; Li, Rui; Shan, Yeqi; Sun, Chaomin

doi:10.1016/j.jbc.2021.101133

Cited by 19 publications

(15 citation statements)

References 45 publications

(48 reference statements)

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“…The marine microorganisms have unique metabolic and physiological abilities, which give them the ability to produce various biological compounds [ 122 , 123 , 124 ], such as EPS. Several marine microbial EPS have been reported to have anticancer activity by the dysfunction of mitochondria, the inhibition of cell proliferation, or the modulation of the immune system [ 42 , 58 , 94 , 125 , 126 , 127 , 128 ]. Matsuda et al studied the marine Pseudomonas polysaccharide B1, and found that it could induce U937 cells’ apoptosis [ 128 ].…”

Section: The Biological Activities Of Marine Epsmentioning

confidence: 99%

“…could also inhibit the growth of Hela, HL-60, and K562 cells in a concentration-dependent manner [ 84 ]. The marine bacterial exopolysaccharide EPS11 could effectively inhibit the adhesion, migration, and invasion of hepatocellular carcinoma cells; this underlying target protein and molecular mechanism was first explored through the β 1-integrin signal pathway by targeting type I collagen [ 126 ]. Recently, one study showed that the newly isolated marine bacterial EPS could enhance antitumor activity in HepG2 cells by affecting the key apoptotic factors and activating the toll-like receptors (TLR) [ 129 ].…”

Section: The Biological Activities Of Marine Epsmentioning

confidence: 99%

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Exopolysaccharides from Marine Microbes: Source, Structure and Application

Zheng

et al. 2022

Marine Drugs

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The unique living environment of marine microorganisms endows them with the potential to produce novel chemical compounds with various biological activities. Among them, the exopolysaccharides produced by marine microbes are an important factor for them to survive in these extreme environments. Up to now, exopolysaccharides from marine microbes, especially from extremophiles, have attracted more and more attention due to their structural complexity, biodegradability, biological activities, and biocompatibility. With the development of culture and separation methods, an increasing number of novel exopolysaccharides are being found and investigated. Here, the source, structure and biological activities of exopolysaccharides, as well as their potential applications in environmental restoration fields of the last decade are summarized, indicating the commercial potential of these versatile EPS in different areas, such as food, cosmetic, and biomedical industries, and also in environmental remediation.

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Section: The Biological Activities Of Marine Epsmentioning

confidence: 99%

Section: The Biological Activities Of Marine Epsmentioning

confidence: 99%

Exopolysaccharides from Marine Microbes: Source, Structure and Application

Zheng

et al. 2022

Marine Drugs

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“…( Liu X. et al, 2022 ). proved that EPS11 can directly target type I collagen (an ECM protein) through the β1-integrin signaling pathway (the receptor that mediates ECM-cell interactions), effectively inhibiting the migration of liver cancer cells ( Liu et al, 2021a ). This research team also confirmed that the filamentous structure promoting cell adhesion was almost completely inhibited when the tumor cells were treated with a 9 nM concentration of EPS11, and that tumor cell migration was reduced under the same conditions.…”

Section: Therapeutic Effect Of Bioactive Substances On Liver Cancermentioning

confidence: 99%

The pathogenesis of liver cancer and the therapeutic potential of bioactive substances

Gao

Jiang²,

Wang³

et al. 2022

Front. Pharmacol.

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Liver cancer is the third most common cause of cancer-related deaths in the world and has become an urgent problem for global public health. Bioactive substances are widely used for the treatment of liver cancer due to their widespread availability and reduced side effects. This review summarizes the main pathogenic factors involved in the development of liver cancer, including metabolic fatty liver disease, viral infection, and alcoholic cirrhosis, and focuses on the mechanism of action of bioactive components such as polysaccharides, alkaloids, phenols, peptides, and active bacteria/fungi. In addition, we also summarize transformation methods, combined therapy and modification of bioactive substances to improve the treatment efficiency against liver cancer, highlighting new ideas in this field.

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“…These structures are organelles widely found in cancer cells, which promote the invasion and migration of cancer cells. By the same mechanism, EPS11 was found to inhibit the migration of human hepatoma Huh7.5 [ 41 ], HepG2 and Bel-7402 cells [ 42 ] by acting on the cell membrane surface, i.e., destroying filiform structures and down-regulating the expression of CD99, an essential factor for cell adhesion, migration and cancer metastasis. Moreover, it has been revealed that EPS11 inhibits the metastatic process in vivo in animal models of metastatic melanoma [ 41 ].…”

Section: Marine Compounds As Migrastaticsmentioning

confidence: 99%

Marine Migrastatics: A Comprehensive 2022 Update

2022

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Metastasis is responsible for the bad prognosis in cancer patients. Advances in research on metastasis prevention focus attention on the molecular mechanisms underlying cancer cell motility and invasion to improve therapies for long-term survival in cancer patients. The so-called “migrastatics” could help block cancer cell invasion and lead to the rapid development of antimetastatic therapies, improving conventional cancer therapies. In the relentless search for migrastatics, the marine environment represents an important source of natural compounds due to its enormous biodiversity. Thus, this review is a selection of scientific research that has pointed out in a broad spectrum of in vitro and in vivo models the anti-cancer power of marine-derived products against cancer cell migration and invasion over the past five years. Overall, this review might provide a useful up-to-date guide about marine-derived compounds with potential interest for pharmaceutical and scientific research on antimetastatic drug endpoints.

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Marine bacterial exopolysaccharide EPS11 inhibits migration and invasion of liver cancer cells by directly targeting collagen I

Cited by 19 publications

References 45 publications

Exopolysaccharides from Marine Microbes: Source, Structure and Application

Exopolysaccharides from Marine Microbes: Source, Structure and Application

The pathogenesis of liver cancer and the therapeutic potential of bioactive substances

Marine Migrastatics: A Comprehensive 2022 Update

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