Unsustainable plastic production, use and mismanagement have resulted in increased plastic pollution in the environment threatening sustainability, especially in the tropics. Countries in the tropics have been disproportionally impacted by plastic pollution due to imports of plastic waste from developed countries, or because tropical Small Island Developing States have become overwhelmed by single-use plastics used widely in the tourism sector. However, plastic pollution is pervasive and is not just limited to the tropics. Plastic pollution has resulted in widespread environmental, economic and social impacts globally. Most plastics are derived from fossil fuels which contribute to climate change via greenhouse gas emissions, and plastic pollution also harms wildlife threatening biodiversity, thus placing enormous pressure on earth’s limited resources. Although downstream strategies to curb plastic pollution exist, they are infective in the face of increased upstream plastic production. Therefore, the international community has recognized that a more holistic approach is required to reduce plastic pollution. Current plastic production and waste generation are still outpacing existing plastic reduction regulations. This viewpoint shows why unsustainable global plastic production has resulted in increased global plastic pollution, including in the tropics, but also highlights how ambitious plastic pollution reduction policies can help transition towards a more sustainable plastics future.