Marine Derived Anticancer Drugs Targeting Microtubule

De, Oindrila; Chatterji, Biswa Prasun

doi:10.2174/1574892812666170109141003

Cited by 4 publications

(1 citation statement)

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“…The two-way separation of sister chromatids is regulated by SAC. Chromosome segregation does not occur until the "correct" checkpoint is determined, which is defined as a proper and stable kinetochore-microtubule attachment (94).…”

Section: Mechanism Of Microtubule-targeting Drugs In Cancer Therapy Block Cell Mitosis and Cycle Progressionmentioning

confidence: 99%

The Role of Microtubules in Pancreatic Cancer: Therapeutic Progress

Albahde

Abdrakhimov

et al. 2021

Front. Oncol.

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Pancreatic cancer has an extremely low prognosis, which is attributable to its high aggressiveness, invasiveness, late diagnosis, and lack of effective therapies. Among all the drugs joining the fight against this type of cancer, microtubule-targeting agents are considered to be the most promising. They inhibit cancer cells although through different mechanisms such as blocking cell division, apoptosis induction, etc. Hereby, we review the functions of microtubule cytoskeletal proteins in tumor cells and comprehensively examine the effects of microtubule-targeting agents on pancreatic carcinoma.

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Section: Mechanism Of Microtubule-targeting Drugs In Cancer Therapy Block Cell Mitosis and Cycle Progressionmentioning

confidence: 99%

The Role of Microtubules in Pancreatic Cancer: Therapeutic Progress

Albahde

Abdrakhimov

et al. 2021

Front. Oncol.

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Integration of Phytochemicals and Phytotherapy into Cancer Precision Medicine

Özenver¹,

Efferth²

2020

Approaching Complex Diseases

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Concepts of individualized therapy in the 1970s and 1980s attempted to develop predictive in vitro tests for individual drug responsiveness without reaching clinical routine. Precision medicine attempts to device novel individual cancer therapy strategies. Using bioinformatics, relevant knowledge is extracted from huge data amounts. However, tumor heterogeneity challenges chemotherapy due to genetically and phenotypically different cell subpopulations, which may lead to refractory tumors. Natural products always served as vital resources for cancer therapy (e.g., Vinca alkaloids, camptothecin, paclitaxel, etc.) and are also sources for novel drugs. Targeted drugs developed to specifically address tumor-related proteins represent the basis of precision medicine. Natural products from plants represent excellent resource for targeted therapies. Phytochemicals and herbal mixtures act multispecifically, i.e. they attack multiple targets at the same time. Network pharmacology facilitates the identification of the complexity of pharmacogenomic networks and new signaling networks that are distorted in tumors. In the present review, we give a conceptual overview, how the problem of drug resistance may be approached by integrating phytochemicals and phytotherapy into academic western medicine. Modern technology platforms (e.g. "-omics" technologies, DNA/RNA sequencing, and network pharmacology) can be applied for diverse treatment modalities such as cytotoxic and targeted chemotherapy as well as phytochemicals and phytotherapy. Thereby, these technologies represent an integrative momentum to merge the best of two worlds: clinical oncology and traditional medicine. In conclusion, the integration of phytochemicals and phytotherapy into cancer precision medicine represents a valuable asset to chemically synthesized chemicals and therapeutic antibodies.

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