Marine-derived κ-carrageenan-coated zinc oxide nanoparticles for targeted drug delivery and apoptosis induction in oral cancer

Marunganathan, Vanitha; Kumar, Meenakshi Sundaram Kishore; Kari, Zulhisyam Abdul; Giri, Jayant; Shaik, Mohammed Rafi; Shaik, Baji; Guru, Ajay

doi:10.1007/s11033-023-09146-1

Cited by 12 publications

(4 citation statements)

References 61 publications

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“…The combination of ZnO NPs with PIP, a bioactive compound derived from black pepper, presents a promising approach for combating both dental pathogens and oral cancer. ZnO NPs have demonstrated potent antimicrobial properties against a wide range of dental pathogens due to their ability to induce oxidative stress and disrupt microbial cell membranes [ 21 ]. Additionally, ZnO NPs have shown potential in inhibiting biofilm formation, a crucial factor in the pathogenesis of dental infections [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

“…X-ray Diffraction analysis (XRD) analysis provided information regarding the crystallographic phases and crystallite size of the NPs. Chemical bonding and functional groups present in the synthesized NPs were investigated using Fourier-transform infrared spectroscopy (FTIR) and Energy dispersive X-ray analysis (EDAX) [ 21 ]. Maintaining precise control over reaction conditions like temperature, pH, and reaction time is crucial for reproducibility.…”

Section: Methodsmentioning

confidence: 99%

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Piperine-coated zinc oxide nanoparticles target biofilms and induce oral cancer apoptosis via BCl-2/BAX/P53 pathway

Shaik,

Kandaswamy,

Guru

et al. 2024

BMC Oral Health

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Background Dental pathogens play a crucial role in oral health issues, including tooth decay, gum disease, and oral infections, and recent research suggests a link between these pathogens and oral cancer initiation and progression. Innovative therapeutic approaches are needed due to antibiotic resistance concerns and treatment limitations. Methods We synthesized and analyzed piperine-coated zinc oxide nanoparticles (ZnO-PIP NPs) using UV spectroscopy, SEM, XRD, FTIR, and EDAX. Antioxidant and antimicrobial effectiveness were evaluated through DPPH, ABTS, and MIC assays, while the anticancer properties were assessed on KB oral squamous carcinoma cells. Results ZnO-PIP NPs exhibited significant antioxidant activity and a MIC of 50 µg/mL against dental pathogens, indicating strong antimicrobial properties. Interaction analysis revealed high binding affinity with dental pathogens. ZnO-PIP NPs showed dose-dependent anticancer activity on KB cells, upregulating apoptotic genes BCL2, BAX, and P53. Conclusions This approach offers a multifaceted solution to combatting both oral infections and cancer, showcasing their potential for significant advancement in oral healthcare. It is essential to acknowledge potential limitations and challenges associated with the use of ZnO NPs in clinical applications. These may include concerns regarding nanoparticle toxicity, biocompatibility, and long-term safety. Further research and rigorous testing are warranted to address these issues and ensure the safe and effective translation of ZnO-PIP NPs into clinical practice.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Piperine-coated zinc oxide nanoparticles target biofilms and induce oral cancer apoptosis via BCl-2/BAX/P53 pathway

Shaik,

Kandaswamy,

Guru

et al. 2024

BMC Oral Health

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“…Molecular docking analysis reveals the mechanisms behind their antibacterial action. These findings imply that ZnO-CR NPs are unique tools for tackling oral infections and oral cancer, presenting a viable way to tackle antimicrobial resistance [ 85 ].…”

Section: The Therapeutic Efficacy Of Zinc Oxide-based Nanomaterials I...mentioning

confidence: 99%

Advancements in the Synthesis and Functionalization of Zinc Oxide-Based Nanomaterials for Enhanced Oral Cancer Therapy

Pei,

Natarajan,

Umapathy

et al. 2024

Molecules

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The fabrication of zinc oxide-based nanomaterials (including natural and synthetic polymers like sulfated polysaccharide, chitosan, and polymethyl methacrylate) has potential to improve oral cancer treatment strategies. This comprehensive review explores the diverse synthesis methods employed to fabricate zinc oxide nanomaterials tailored for oral cancer applications. Several synthesis processes, particularly sol–gel, hydrothermal, and chemical vapor deposition approaches, are thoroughly studied, highlighting their advantages and limitations. The review also examines how synthesis parameters, such as precursor selection, the reaction temperature, and growth conditions, influence both the physicochemical attributes and biological efficacy of the resulting nanomaterials. Furthermore, recent advancements in surface functionalization and modification strategies targeted at improving the targeting specificity and pharmaceutical effectiveness of zinc oxide-based nanomaterials in oral cancer therapy are elucidated. Additionally, the review provides insights into the existing issues and prospective views in the field, emphasizing the need for further research to optimize synthesis methodologies and elucidate the mechanisms underlying the efficacy of zinc oxide-based nanoparticles in oral cancer therapy.

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“…The growth of marine microorganisms in a special environment produces a variety of secondary metabolites with special chemical structures [ 4 ]. Many secondary metabolites have a variety of pharmacological effects, such as antibacterial, anti-inflammatory, anti-tumour, or antiviral effects, so they have received extensive attention and application [ 5 , 6 , 7 ]. As a result, marine microbial secondary metabolites have become a very promising source of drug candidates [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Avellanin A Has an Antiproliferative Effect on TP-Induced RWPE-1 Cells via the PI3K-Akt Signalling Pathway

Xu,

Cao,

Zhang

et al. 2024

Marine Drugs

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Cyclic pentapeptide compounds have garnered much attention as a drug discovery resource. This study focused on the characterization and anti-benign prostatic hyperplasia (BPH) properties of avellanin A from Aspergillus fumigatus fungus in marine sediment samples collected in the Beibu Gulf of Guangxi Province in China. The antiproliferative effect and molecular mechanism of avellanin A were explored in testosterone propionate (TP)-induced RWPE-1 cells. The transcriptome results showed that avellanin A significantly blocked the ECM–receptor interaction and suppressed the downstream PI3K-Akt signalling pathway. Molecular docking revealed that avellanin A has a good affinity for the cathepsin L protein, which is involved in the terminal degradation of extracellular matrix components. Subsequently, qRT-PCR analysis revealed that the expression of the genes COL1A1, COL1A2, COL5A2, COL6A3, MMP2, MMP9, ITGA2, and ITGB3 was significantly downregulated after avellanin A intervention. The Western blot results also confirmed that it not only reduced ITGB3 and FAK/p-FAK protein expression but also inhibited PI3K/p-PI3K and Akt/p-Akt protein expression in the PI3K-Akt signalling pathway. Furthermore, avellanin A downregulated Cyclin D1 protein expression and upregulated Bax, p21WAF1/Cip1, and p53 proapoptotic protein expression in TP-induced RWPE-1 cells, leading to cell cycle arrest and inhibition of cell proliferation. The results of this study support the use of avellanin A as a potential new drug for the treatment of BPH.

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Marine-derived κ-carrageenan-coated zinc oxide nanoparticles for targeted drug delivery and apoptosis induction in oral cancer

Cited by 12 publications

References 61 publications

Piperine-coated zinc oxide nanoparticles target biofilms and induce oral cancer apoptosis via BCl-2/BAX/P53 pathway

Piperine-coated zinc oxide nanoparticles target biofilms and induce oral cancer apoptosis via BCl-2/BAX/P53 pathway

Advancements in the Synthesis and Functionalization of Zinc Oxide-Based Nanomaterials for Enhanced Oral Cancer Therapy

Avellanin A Has an Antiproliferative Effect on TP-Induced RWPE-1 Cells via the PI3K-Akt Signalling Pathway

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