Marine endophytes from the Indian coasts: The untapped sources of sustainable anticancer drug discovery

Kamat, Siya; Kumari, Madhuree; Sajna, Kuttuvan Valappil; Mohan, Shruthi; Jayabaskaran, Chelliah

doi:10.1016/j.scp.2022.100675

Cited by 6 publications

(3 citation statements)

References 176 publications

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“…Among the natural compounds, flavonoids are vital secondary metabolites found in most fruits and vegetables [13]. Widely known for their in vitro and in vivo anticancer properties [14].…”

Section: Introductionmentioning

confidence: 99%

The modulatory effect of oolong tea polyphenols on intestinal flora and hypothalamus gene expression in a circadian rhythm disturbance mouse model

Liang¹,

Zhong²,

Ma³

et al. 2024

Food Science and Human Wellness

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Apigenin, a natural flavonoid has been reported against a variety of cancer types. However, it is unclear whether apigenin can promote autophagy and ferroptosis in Ishikawa cells. There are few reports on the mechanism of apigenin on autophagy and ferroptosis of endometrial cancer Ishikawa cells. We found that iron accumulation, lipid peroxidation, GSH consumption, p62, HMOX1, and ferritin were increased, while, SLC7A11 and GPX4 were decreased. Fer-1, an iron-death inhibitor could reverse the effects of apigenin in Ishikawa cells. On the other hand, apigenin could promote autophagy via up-regulating Beclin 1, ULK1, ATG5, ATG13, and LC3B and down-regulating AMPK, mTOR, P70S6K, and ATG4. Furthermore, apigenin could inhibit tumor tissue proliferation and restrict tumor growth via ferroptosis in vivo.

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“…Among the natural compounds, flavonoids are vital secondary metabolites found in most fruits and vegetables [13]. Widely known for their in vitro and in vivo anticancer properties [14].…”

Section: Introductionmentioning

confidence: 99%

The modulatory effect of oolong tea polyphenols on intestinal flora and hypothalamus gene expression in a circadian rhythm disturbance mouse model

Liang¹,

Zhong²,

Ma³

et al. 2024

Food Science and Human Wellness

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“…However, research on endophytic fungus from tropical locations is still very limited. Several recent ndings have detailed the isolation of endophytic fungi and bacteria and the discovery of their bioactive compounds as materials for producing new antibiotics from macroalgae (de Felício et al, 2015;Kamat et al, 2022;Mathew et al, 2023). e need for the availability of new antimicrobial sources that can reduce the use of commercial antibiotics can be produced by endophytic fungi.…”

Section: Introductionmentioning

confidence: 99%

Isolation and Molecular Identification of Endophytic Fungi Associated with Brown Algae for Inhibiting Escherichia coli ESBL

Wiradana,

Permatasari,

Sari

et al. 2024

J. Appl. Vet. Sci. Technol

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Background: The marine environment is the main source of research on natural products in the future. In addition, marine microorganisms have been identified as a natural source capable of developing new antibiotic compounds, including controlling urinary tract infections caused by Escherichia coli ESBL. Purpose: This study aims to isolate, select, and test the potential of brown macroalgae endophytic fungi (Phaeophyceae) collected from the coastal waters of Sanur, Bali Province. Methods: Three types of brown algae were collected from Sanur Beach and their endophytic fungi were isolated using PDA media. Antibacterial activity was determined by measuring the inhibition zone and determining the inhibition category. The selected isolates were cultured and the phytochemical profile was determined qualitatively. In addition, molecular identification using the Internal Transcribed Spacer (ITS) primer set and comparison with the GenBank (NCBI) database were carried out in this study. Results: The results showed that 10 isolates were successfully isolated from three types of brown macroalgae. It was found that isolates T1, S1, and P3 had the highest inhibition in the very strong category. There were variations in mycelial weight, pH value, and inhibition shown by the culture filtrate of the three endophytic fungal isolates against Escherichia coli ESBL. Isolate S1 had the highest phytochemical profile, namely alkaloids, triterpenoids, saponins, and phenolics. The three endophytic fungal isolates showed isolate T1 (Phlebiopsis magnicystidiata) (MT5617191), isolate P3 (Neurospora crassa strain RT3M) (MT1028551), and isolate S1 (Peniophora sp.) (MH2680421). Conclusion: The results of this study provide initial information regarding the potential of bioprospecting brown macroalgal endophytic fungi as a source of new antibiotics against Escherichia coli ESBL.

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“…Penicillin, the first antibiotic, was discovered from Penicillium notatum in 1928. Following this revolutionary discovery, several other natural sources, such as plants (Vaou et al, 2021 ), endophytic fungi (Kamat et al, 2022b ), marine organisms (Kamat et al, 2020a ; Sajna et al, 2020 ), and lichens (Kumari et al, 2022 ) have been explored for natural products with therapeutic properties (Kamat et al, 2020b ). Griseofulvin derivatives are examples of naturally occurring antibiotics commonly produced by P. griseofulvum (Zhang et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Emergence of microbial resistance against nanoparticles: Mechanisms and strategies

Kamat

Kumari

2023

Front. Microbiol.

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Antimicrobial nanoparticles have gained the status of a new generation of drugs that can kill bacterial pathogens by multiple means; however, nanoparticle resistance acquired by some bacterial pathogens has evoked a cause of concern. Several reports suggested that bacteria can develop nanoparticles, specifically metal nanoparticle resistance, by mechanisms: nanoparticle transformation-induced oxidative stress, membrane alterations, reversible adaptive resistance, irreversible modifications to cell division, and a change in bacterial motility and resistance. Surface properties, concentration and aggregation of nanoparticles, biofilm forming and metal exclusion capacity, and R plasmid and flagellin synthesis by bacteria are crucial factors in the development of nanoparticle resistance in bacteria. Studies reported the resistance reversal by modifying the surface corona of nanoparticles or inhibiting flagellin production by bacterial pathogens. Furthermore, strict regulation regarding the use and disposal of nano-waste across the globe, the firm knowledge of microbe–nanoparticle interaction, and the regulated disposal of nanoparticles in soil and water is required to prevent microbes from developing nanoparticle resistance.

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Marine endophytes from the Indian coasts: The untapped sources of sustainable anticancer drug discovery

Cited by 6 publications

References 176 publications

The modulatory effect of oolong tea polyphenols on intestinal flora and hypothalamus gene expression in a circadian rhythm disturbance mouse model

The modulatory effect of oolong tea polyphenols on intestinal flora and hypothalamus gene expression in a circadian rhythm disturbance mouse model

Isolation and Molecular Identification of Endophytic Fungi Associated with Brown Algae for Inhibiting Escherichia coli ESBL

Emergence of microbial resistance against nanoparticles: Mechanisms and strategies

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