Marine fungal metabolite 1386A alters the microRNA profile in MCF-7 breast cancer cells

Tang, Bin; He, Weiling; Cheng, Zheng; Cheang, Tuck−Yun; Zhang, Xi-Fang; Wu, Hui; Yang, Haisong

doi:10.3892/mmr.2011.697

Cited by 3 publications

(3 citation statements)

References 58 publications

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“…The marine fungal metabolite 1386A, a small-molecule compound derived from a mangrove fungus, was reported to significantly inhibit MCF-7 cell proliferation in a time- and dose-dependent manner ( Tang et al, 2012 ). Analysis of miRNA expression profiles induced by 1386A revealed that several deregulated miRNAs may play complex roles in 1386A-induced breast cancer cytotoxicity, including the unregulated tumor suppressor miRNAs (let-7a and miR-15/16) and the downregulated oncogenic miRNAs (miR-21, miR-27a and miR-633) ( Tang et al, 2012 ). This suggests that 1386A may be an effective antitumor drug, and its molecular mechanism may be related to miRNAs, which needs further study.…”

Section: Ncrnas As Oncogenes or Tumor Suppressors Involved In The Ant...mentioning

confidence: 99%

Non-coding RNA-related antitumor mechanisms of marine-derived agents

et al. 2022

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In the last two decades, natural active substances have attracted great attention in developing new antitumor drugs, especially in the marine environment. A series of marine-derived compounds or derivatives with potential antitumor effects have been discovered and developed, but their mechanisms of action are not well understood. Emerging studies have found that several tumor-related signaling pathways and molecules are involved in the antitumor mechanisms of marine-derived agents, including noncoding RNAs (ncRNAs). In this review, we provide an update on the regulation of marine-derived agents associated with ncRNAs on tumor cell proliferation, apoptosis, cell cycle, invasion, migration, drug sensitivity and resistance. Herein, we also describe recent advances in marine food-derived ncRNAs as antitumor agents that modulate cross-species gene expression. A better understanding of the antitumor mechanisms of marine-derived agents mediated, regulated, or sourced by ncRNAs will provide new biomarkers or targets for potential antitumor drugs from preclinical discovery and development to clinical application.

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Section: Ncrnas As Oncogenes or Tumor Suppressors Involved In The Ant...mentioning

confidence: 99%

Non-coding RNA-related antitumor mechanisms of marine-derived agents

et al. 2022

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“…Previous studies have shown that lenalidomide and emodin may be used for the treatment of GBM (61,62). Besides, experiments have demonstrated that marine fungal metabolite 1386A has strong cytotoxicity towards cancer cells and can alter the miRNA profiles of McF-7 breast cancer cells (63). It was deduced that 1836A might be a novel potential small-molecule treatment for GBM.…”

Section: Prediction Of Small Molecule Drugs For Gbm Treatmentmentioning

confidence: 99%

Genome‑wide DNA methylation regulation analysis of long non‑coding RNAs in glioblastoma

Zhao

et al. 2020

Int J Mol Med

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Glioblastoma (GBM) is a malignant brain tumor associated with high mortality. Long non-coding RNAs (lncRNAs) are increasingly being recognized as its modulators. However, it remains mostly unexplored how lncRNAs are mediated by dNA methylation in GBM. The present study integrated multi-omics data to analyze the epigenetic dysregulation of lncRNAs in GBM. Widely aberrant methylation in the lncRNA promoters was observed, and the lncRNA promoters exhibited a more hypomethylated pattern in GBM. By combining transcriptional datasets, it was possible identify the lncRNAs whose transcriptional changes might be associated with the aberrant promoter methylation. Then, a methylation-mediated lncRNA regulatory network and functional enrichment analysis of aberrantly methylated lncRNAs showed that lncRNAs with different methylation patterns were involved in diverse GBM progression-related biological functions and pathways. Specifically, four lncRNAs whose increased expression may be regulated by the corresponding promoter hypomethylation were evaluated to have an excellent diagnostic effect and clinical prognostic value. Finally, through the construction of drug-target association networks, the present study identified potential therapeutic targets and small-molecule drugs for GBM treatment. The present study provides novel insights for understanding the regulation of lncRNAs by dNA methylation and developing cancer biomarkers in GBM.

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“…1386A (17.1 µmol/l) significantly altered the global miRNA expression profile of the MCF-7 cells at 48 h. Forty-five miRNAs have been differentially expressed in MCF-7 cells. Target prediction suggests that these miRNAs potentially target many oncogenes and tumor-suppressor genes associated with cancer development, progression and metastasis [58]. Physcion (11.8 mg) isolated from the culture broth extract (1710 mg) of marine derived fungi significantly induce cell apoptosis through down-regulating of Bcl-2 expression, up-regulating of Bax expression, and activating the caspase-3 pathway.…”

Section: Apoptosis Inducing Metabolitesmentioning

confidence: 99%

Natural Products with Anticancer Activity from Marine Fungi

Karuppiah

Zhang

2014

Handbook of Anticancer Drugs From Marine Origin

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Cancer is one of the major diseases, which require the improved drugs with fewer side effects. Until now, several marine natural products have been accessed for the anticancer property and few of them are in clinical trials too. Marine fungi are taxonomically diverse, largely productive, biologically active, and chemically unique offering a great scope for discovery of new anticancer drugs. The natural products isolated from the marine fungi are possibly inhibiting the processes such as inflammation, cell differentiation and survival, and metastasis of various signal transduction pathways and their by reducing the risk of cancer. In this chapter, we have discussed about the anticancer, anti-inflammatory and cytotoxic activities of marine derived fungi.

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Marine fungal metabolite 1386A alters the microRNA profile in MCF-7 breast cancer cells

Cited by 3 publications

References 58 publications

Non-coding RNA-related antitumor mechanisms of marine-derived agents

Non-coding RNA-related antitumor mechanisms of marine-derived agents

Genome‑wide DNA methylation regulation analysis of long non‑coding RNAs in glioblastoma

Natural Products with Anticancer Activity from Marine Fungi

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