Marine Invertebrates of Boka Kotorska Bay Unique Sources for Bioinspired Materials Science

Ehrlich, Hermann; Bazhenov, Vasilii V.; Meschke, Stephan; Bürger, Marcel; Ehrlich, André; Petović, Slavica; Đurović, Mirko

doi:10.1007/698_2016_25

Cited by 10 publications

(8 citation statements)

References 66 publications

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“…The indisputable advantages of the Verongiida sponges in comparison with other demosponges include their unique ability to regenerate tissues [ 46 , 47 ], which determines the progress in their cultivation using marine farming methods [ 48 – 51 ]. These marine sponges are now considered as renewable sources of both biological materials (i.e.…”

Section: Introductionmentioning

confidence: 99%

Marine biomimetics: bromotyrosines loaded chitinous skeleton as source of antibacterial agents

et al. 2021

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Section: Introductionmentioning

confidence: 99%

Marine biomimetics: bromotyrosines loaded chitinous skeleton as source of antibacterial agents

et al. 2021

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“…To the best of our knowledge, data on the impact of Aeroplysinin-1 and Isofistularin-3 pheochromocytoma cells are lacking. The choice to study bromotyrosines of the A. aerophoba demosponge origin was motivated by well-developed marine farming of this sponge species and its recognition as a renewable source to isolate large amounts of both bromotyrosines and chitin-based scaffolds [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Anti-Tumorigenic and Anti-Metastatic Activity of the Sponge-Derived Marine Drugs Aeroplysinin-1 and Isofistularin-3 against Pheochromocytoma In Vitro

et al. 2018

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Over 10% of pheochromocytoma and paraganglioma (PPGL) patients have malignant disease at their first presentation in the clinic. Development of malignancy and the underlying molecular pathways in PPGLs are poorly understood and efficient treatment strategies are missing. Marine sponges provide a natural source of promising anti-tumorigenic and anti-metastatic agents. We evaluate the anti-tumorigenic and anti-metastatic potential of Aeroplysinin-1 and Isofistularin-3, two secondary metabolites isolated from the marine sponge Aplysina aerophoba, on pheochromocytoma cells. Aeroplysinin-1 diminished the number of proliferating cells and reduced spheroid growth significantly. Beside these anti-tumorigenic activity, Aeroplysinin-1 decreased the migration ability of the cells significantly (p = 0.01), whereas, the invasion capacity was not affected. Aeroplysinin-1 diminished the high adhesion capacity of the MTT cells to collagen (p < 0.001) and, furthermore, reduced the ability to form spheroids significantly. Western Blot and qRT-PCR analysis showed a downregulation of integrin β1 that might explain the lower adhesion and migration capacity after Aeroplysinin-1 treatment. Isofistularin-3 showed only a negligible influence on proliferative and pro-metastatic cell properties. These in vitro investigations show promise for the application of the sponge-derived marine drug, Aeroplysinin-1 as anti-tumorigenic and anti-metastatic agent against PPGLs for the first time.

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“…This direction has gained enormous attention especially in aspects where there is an interest in the development of materials, which feature not only hierarchical and nanostructural organization but three-dimensional (3D) architecture at micro- and macrolevels. Such kind of 3D scaffolds can be isolated from diverse marine demosponges, which are cultivated worldwide under marine ranching conditions [11]. Mostly, their fibrous skeletons are made of aminopolysaccharide chitin (sponges in the order Verongida) or proteinaceous spongin (representatives of the order Dictyoceratida).…”

Section: Introductionmentioning

confidence: 99%

Immobilization of Titanium(IV) Oxide onto 3D Spongin Scaffolds of Marine Sponge Origin According to Extreme Biomimetics Principles for Removal of C.I. Basic Blue 9

et al. 2017

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Abstract:The aim of extreme biomimetics is to design a bridge between extreme biomineralization and bioinspired materials chemistry, where the basic principle is to exploit chemically and thermally stable, renewable biopolymers for the development of the next generation of biologically inspired advanced and functional composite materials. This study reports for the first time the use of proteinaceous spongin-based scaffolds isolated from marine demosponge Hippospongia communis as a three-dimensional (3D) template for the hydrothermal deposition of crystalline titanium dioxide. Scanning electron microscopy (SEM) assisted with energy dispersive X-ray spectroscopy (EDS) mapping, low temperature nitrogen sorption, thermogravimetric (TG) analysis, X-ray diffraction spectroscopy (XRD), and attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectroscopy are used as characterization techniques. It was found that, after hydrothermal treatment crystalline titania in anatase form is obtained, which forms a coating around spongin microfibers through interaction with negatively charged functional groups of the structural protein as well as via hydrogen bonding. The material was tested as a potential heterogeneous photocatalyst for removal of C.I. Basic Blue 9 dye under UV irradiation. The obtained 3D composite material shows a high efficiency of dye removal through both adsorption and photocatalysis.

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Marine Invertebrates of Boka Kotorska Bay Unique Sources for Bioinspired Materials Science

Cited by 10 publications

References 66 publications

Marine biomimetics: bromotyrosines loaded chitinous skeleton as source of antibacterial agents

Marine biomimetics: bromotyrosines loaded chitinous skeleton as source of antibacterial agents

Anti-Tumorigenic and Anti-Metastatic Activity of the Sponge-Derived Marine Drugs Aeroplysinin-1 and Isofistularin-3 against Pheochromocytoma In Vitro

Immobilization of Titanium(IV) Oxide onto 3D Spongin Scaffolds of Marine Sponge Origin According to Extreme Biomimetics Principles for Removal of C.I. Basic Blue 9

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