Marine Invertebrates: Sponges

Nakao, Yoichi; Fusetani, Nobuhiro

doi:10.1016/b978-008045382-8.00043-5

Cited by 10 publications

(3 citation statements)

References 284 publications

(112 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Discodermolide is a polypropionate-based specific secondary metabolite isolated from the sea sponge. Discodermia dissolute in the past years was found to stabilize microtubules [ 217 ], and its synergistic potential for paclitaxel (Taxol) efficacy has been studied. The experimental studies for evaluation of drug combination of discodermolide and taxol indicated drug-induced aneuploidy enhancing effect rather than mitotic arrest in human ovarian cancer cells and in an in vivo model of ovarian carcinoma.…”

Section: Paclitaxel and Other Drugs: Emphasis On Synergistic And Potentiation Reactionsmentioning

confidence: 99%

Paclitaxel: Application in Modern Oncology and Nanomedicine‐Based Cancer Therapy

Sharifi‐Rad

Quispe

Patra

et al. 2021

Oxidative Medicine and Cellular Longevity

154

View full text Add to dashboard Cite

Paclitaxel is a broad-spectrum anticancer compound, which was derived mainly from a medicinal plant, in particular, from the bark of the yew tree Taxus brevifolia Nutt. It is a representative of a class of diterpene taxanes, which are nowadays used as the most common chemotherapeutic agent against many forms of cancer. It possesses scientifically proven anticancer activity against, e.g., ovarian, lung, and breast cancers. The application of this compound is difficult because of limited solubility, recrystalization upon dilution, and cosolvent-induced toxicity. In these cases, nanotechnology and nanoparticles provide certain advantages such as increased drug half-life, lowered toxicity, and specific and selective delivery over free drugs. Nanodrugs possess the capability to buildup in the tissue which might be linked to enhanced permeability and retention as well as enhanced antitumour influence possessing minimal toxicity in normal tissues. This article presents information about paclitaxel, its chemical structure, formulations, mechanism of action, and toxicity. Attention is drawn on nanotechnology, the usefulness of nanoparticles containing paclitaxel, its opportunities, and also future perspective. This review article is aimed at summarizing the current state of continuous pharmaceutical development and employment of nanotechnology in the enhancement of the pharmacokinetic and pharmacodynamic features of paclitaxel as a chemotherapeutic agent.

show abstract

Section: Paclitaxel and Other Drugs: Emphasis On Synergistic And Potentiation Reactionsmentioning

confidence: 99%

Paclitaxel: Application in Modern Oncology and Nanomedicine‐Based Cancer Therapy

Sharifi‐Rad

Quispe

Patra

et al. 2021

Oxidative Medicine and Cellular Longevity

154

View full text Add to dashboard Cite

show abstract

“…Of the natural products derived from the Animalia kingdom, the vast majority (greater than 75%) were from the Porifera (Sea sponge) Phylum (Figure 3), within which many orders were represented (Figure 4). It should be noted that there are some instances where natural products obtained from Porifera have been later determined to originate from a microorganism present in the sponge; [35] for the purpose of this study, compounds are considered to have originated from the sponge unless a microorganism has been deemed to be the source. The bacterium studied all come from three Phylum (actinobacteria, firmacutes and proteobacteria, Figure 5), while only one Phylum of fungi, ascomycota have been shown to exist in deep seas and provide marine natural products of interest, in the years studied.…”

Section: Resultsmentioning

confidence: 99%

A Chemometric Analysis of Deep-Sea Natural Products

Pilkington

2019

Molecules

View full text Add to dashboard Cite

Deep-sea natural products have been created by unique marine organisms that thrive in a challenging environment of extreme conditions for its inhabitants. In this study, 179 deep-sea natural products isolated from 2009 to 2013 were investigated by analysing their physicochemical properties that are important indicators of the ADMET (Absorption, Distribution, Metabolism, Excretion and Toxicity) profile of a compound. The study and analysis of these molecular descriptors and characteristics enabled the defining of these compounds in various chemical spaces, particularly as an indication of their drug-likeness and position in chemical space and is the first to be conducted to analyse deep-sea derived natural products. It was found that ~40% of all deep-sea natural products were drug-like and 2/3 were within Known Drug Space (KDS), highlighting the high drug-likeness of a significant proportion of deep-sea natural products, most of which have already been shown to have notable biological activities, that should be further investigated as potential therapeutics. Furthermore, this study was able to reveal the general structural differences between compounds from Animalia, Bacteria and Fungi organisms where it was observed that natural products from members of the Animalia kingdom are structurally more varied than compounds from bacteria and fungi. It was also noted that, in general, fungi-derived compounds occupy a more favourable position in drug-like chemical space and are a rich and promising source of biologically-active natural products for the purposes of drug development and therapeutic application.

show abstract

“…Preclinical research has shown that marine macrolides, like Spongistatin and Makaluvamines, can protect neurons. These chemicals have the ability to cure neurodegenerative diseases because they are neurotrophic, improve neuronal survival, and reduce neuroinflammation [15,16].…”

Section: Pharmacological Activitiesmentioning

confidence: 99%

Marine Macrolides: An Indepth Survey of Potential Therapeutic Activities

2024

JMSR

View full text Add to dashboard Cite

Marine macrolides have a broad variety of biological activities, and this editorial explores those activities, as well as their potential effects on human health. There is an abundance of potential therapeutic agents to be discovered in the vast and enigmatic area of Earth's oceans. The extensive biodiversity and distinctive chemical compositions of marine animals have always captivated scientists, presenting a valuable reservoir of chemicals that hold promise for medicinal purposes. Within the broad category of chemicals, marine macrolides have attracted significant attention due to their wide range of biological activity and considerable potential for pharmacological use.

show abstract

Marine Invertebrates: Sponges

Cited by 10 publications

References 284 publications

Paclitaxel: Application in Modern Oncology and Nanomedicine‐Based Cancer Therapy

Paclitaxel: Application in Modern Oncology and Nanomedicine‐Based Cancer Therapy

A Chemometric Analysis of Deep-Sea Natural Products

Marine Macrolides: An Indepth Survey of Potential Therapeutic Activities

Contact Info

Product

Resources

About