Marine microbial L-glutaminase: from pharmaceutical to food industry

Barzkar, Noora; Sohail, Muhammad; Jahromi, Saeid Tamadoni; Nahavandi, Reza; Khodadadi, Mojgan

doi:10.1007/s00253-021-11356-1

Cited by 24 publications

(12 citation statements)

References 73 publications

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“…Even though these enzymes have been characterized from a wide range of different sources, microbial fibrinolytic enzymes are considered attractive tools due to their features, such as enhanced specificity [8], low production cost [8], comparatively high yield [28] and the possibility to be genetically modified by recombinant DNA technology and protein engineering approaches [29]. Marine ecosystems serve as a reservoir of microorganisms producing important therapeutic metabolites, especially enzymes [30][31][32][33][34][35][36][37][38][39], but they remain largely unexplored to date. Due to the wide biodiversity of the marine environment, marine microorganisms can provide a diverse array of enzymes for biotechnological development, with possible improved pharmacological properties and lesser side effects [40].…”

Section: Introductionmentioning

confidence: 99%

Marine Microbial Fibrinolytic Enzymes: An Overview of Source, Production, Biochemical Properties and Thrombolytic Activity

2022

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Cardiovascular diseases (CVDs) have emerged as a major threat to global health resulting in a decrease in life expectancy with respect to humans. Thrombosis is one of the foremost causes of CVDs, and it is characterized by the unwanted formation of fibrin clots. Recently, microbial fibrinolytic enzymes due to their specific features have gained much more attention than conventional thrombolytic agents for the treatment of thrombosis. Marine microorganisms including bacteria and microalgae have the significant ability to produce fibrinolytic enzymes with improved pharmacological properties and lesser side effects and, hence, are considered as prospective candidates for large scale production of these enzymes. The current review presents an outline regarding isolation sources, production, features, and thrombolytic potential of fibrinolytic biocatalysts from marine microorganisms identified so far.

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Section: Introductionmentioning

confidence: 99%

Marine Microbial Fibrinolytic Enzymes: An Overview of Source, Production, Biochemical Properties and Thrombolytic Activity

2022

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“…Fungal aspartic proteases from A. niger are used for the preparation of digestive powders [22]. L-glutaminase from Aspergillus fumigatus and Penicillium allii is used for the treatment of leukaemia by inhibiting the growth of cancerous cells [214]. Alkaline protease is also used as a digestible in the pharmaceutical industry to treat cystic fibrosis [215,216].…”

Section: Medical and Pharmaceutical Industrymentioning

confidence: 99%

Fungal Proteases as Emerging Biocatalysts to Meet the Current Challenges and Recent Developments in Biomedical Therapies: An Updated Review

Naeem

Manzoor²,

Abid

et al. 2022

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With the increasing world population, demand for industrialization has also increased to fulfill humans’ living standards. Fungi are considered a source of essential constituents to produce the biocatalytic enzymes, including amylases, proteases, lipases, and cellulases that contain broad-spectrum industrial and emerging applications. The present review discussed the origin, nature, mechanism of action, emerging aspects of genetic engineering for designing novel proteases, genome editing of fungal strains through CRISPR technology, present challenges and future recommendations of fungal proteases. The emerging evidence revealed that fungal proteases show a protective role to many environmental exposures and discovered that an imbalance of protease inhibitors and proteases in the epithelial barriers leads to the protection of chronic eosinophilic airway inflammation. Moreover, mitoproteases recently were found to execute intense proteolytic processes that are crucial for mitochondrial integrity and homeostasis function, including mitochondrial biogenesis, protein synthesis, and apoptosis. The emerging evidence revealed that CRISPR/Cas9 technology had been successfully developed in various filamentous fungi and higher fungi for editing of specific genes. In addition to medical importance, fungal proteases are extensively used in different industries such as foods to prepare butter, fruits, juices, and cheese, and to increase their shelf life. It is concluded that hydrolysis of proteins in industries is one of the most significant applications of fungal enzymes that led to massive usage of proteomics.

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“…Likewise, marine species of Aureobasidium pullulans, black yeast, has also been reported for EG and exoglucanase production [80]. Despite the biotechnological importance of marine-derived enzymes [81][82][83], the biotechnological application of marine-derived cellulolytic yeast has yet to be established.…”

Section: Cellulolytic Yeastsmentioning

confidence: 99%

Cellulolytic and Xylanolytic Enzymes from Yeasts: Properties and Industrial Applications

et al. 2022

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Lignocellulose, the main component of plant cell walls, comprises polyaromatic lignin and fermentable materials, cellulose and hemicellulose. It is a plentiful and renewable feedstock for chemicals and energy. It can serve as a raw material for the production of various value-added products, including cellulase and xylanase. Cellulase is essentially required in lignocellulose-based biorefineries and is applied in many commercial processes. Likewise, xylanases are industrially important enzymes applied in papermaking and in the manufacture of prebiotics and pharmaceuticals. Owing to the widespread application of these enzymes, many prokaryotes and eukaryotes have been exploited to produce cellulase and xylanases in good yields, yet yeasts have rarely been explored for their plant-cell-wall-degrading activities. This review is focused on summarizing reports about cellulolytic and xylanolytic yeasts, their properties, and their biotechnological applications.

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Marine microbial L-glutaminase: from pharmaceutical to food industry

Cited by 24 publications

References 73 publications

Marine Microbial Fibrinolytic Enzymes: An Overview of Source, Production, Biochemical Properties and Thrombolytic Activity

Marine Microbial Fibrinolytic Enzymes: An Overview of Source, Production, Biochemical Properties and Thrombolytic Activity

Fungal Proteases as Emerging Biocatalysts to Meet the Current Challenges and Recent Developments in Biomedical Therapies: An Updated Review

Cellulolytic and Xylanolytic Enzymes from Yeasts: Properties and Industrial Applications

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