Marine Microorganisms as a Source of New Natural Products

Bernan, Vernan S.; Greenstein, Michael; Maiese, William M.

doi:10.1016/s0065-2164(08)70223-5

Cited by 175 publications

(114 citation statements)

References 62 publications

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“…Bacteria capable of producing antibiotics are commonly associated with various marine invertebrates (Jensen & Fenical 1994, Bernan et al 1997, Müller et al 2004. Several Alteromonas spp.…”

Section: Introductionmentioning

confidence: 99%

Influence of microbial interactions on the susceptibility of Karenia spp. to algicidal bacteria

Roth¹,

Mikulski²,

Doucette³

2008

Aquat. Microb. Ecol.

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A bacterial strain (D38BY) belonging to the family Flavobacteriaceae and antagonistic towards an algicidal bacterium (strain S03; Flavobacteriaceae) was isolated from a culture of the red tide dinoflagellate Karenia brevis that had previously been characterized as resistant to attack by strain S03. This antagonistic bacterium increased the survival time of otherwise susceptible, bacteriafree K. brevis cultures in a concentration-dependent manner during exposure to the algicidal bacterium. Experimental evidence indicated that direct contact was required in order for strain D38BY to inhibit the killing activity of algicidal strain S03. While further work is needed to determine its precise mode of action, the antagonistic properties of strain D38BY provide further evidence that the resistance or susceptibility of certain algal taxa to algicidal attack can be more a function of interactions within the ambient microbial community than an intrinsic property of the alga. KEY WORDS: Algicidal bacteria · Antagonism · CFB complex · Karenia brevis · Microbial interactions Resale or republication not permitted without written consent of the publisherAquat Microb Ecol 50: [251][252][253][254][255][256][257][258][259] 2008 Previous studies have shown that bacteria in contact with organic matter have a greater tendency to inhibit the growth of other bacteria (Nair & Simidu 1987, Burgess et al. 1999. Long & Azam (2001) reported that the number of bacterial strains inhibited by attached bacteria was approximately 3 times higher than those adversely affected by free-living bacteria. Grossart et al. (2004) found that over 50% of strains isolated from marine aggregates were capable of inhibiting at least 1 other bacterium. Although these studies highlight the contributions of attached bacteria, free-living microbes also warrant consideration. Mayali & Doucette (2002) showed that resistance and susceptibility to an algicidal bacterium could be transferred among cultures of the red tide dinoflagellate Karenia brevis simply by exchanging the native freeliving microbial communities associated with susceptible and resistant isolates. Their findings implicated interactions among bacteria as a potential mechanism for modulating the killing activity of algicidal strains. The ecological significance of antagonistic or inhibitory interactions between bacteria remains largely speculative. Nonetheless, such interactions could influence competition for nutrients or space (Holmström & Kjelleberg 1999) and lead to changes in microbial species composition that may, in turn, alter the nature and rates of bacterially-mediated carbon cycling (Martinez et al. 1996, Long et al. 2003. A better understanding of these relationships and knowledge of the key species involved are essential for predicting their impacts on marine ecosystems. Our goal was to isolate and characterize the antagonistic microbial component(s) of a Karenia brevis culture responsible for impeding the killing activity of an algicidal bacterium reported as lethal to other ...

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“…Bacteria capable of producing antibiotics are commonly associated with various marine invertebrates (Jensen & Fenical 1994, Bernan et al 1997, Müller et al 2004. Several Alteromonas spp.…”

Section: Introductionmentioning

confidence: 99%

Influence of microbial interactions on the susceptibility of Karenia spp. to algicidal bacteria

Roth¹,

Mikulski²,

Doucette³

2008

Aquat. Microb. Ecol.

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“…These bacteria produce about 75% of medically useful agents [3] including a wide array of anti-infective, antibacterial, antifungal, and antitumor agents [4,5]. The decreasing rate of discovery of novel drugs from established terrestrial sources has motivated the evaluation of new sources of chemically diverse bioactive compounds [6]. The oceans represent an under-explored environment for microbial diversity and novel secondary metabolites.…”

Section: Introductionmentioning

confidence: 99%

Streptokordin, a New Cytotoxic Compound of the Methylpyridine Class from a Marine-derived Streptomyces sp. KORDI-3238

et al. 2006

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A new cytotoxic compound, streptokordin, and four known compounds, nonactic acid, dilactone, trilactone, and nonactin, were isolated from the fermentation broth of a marine actinomycete strain collected in deep-sea sediments. Biochemical tests and 16S rDNA analysis indicated that the strain belongs to the genus Streptomyces. This actinomycete produces various bioactive secondary metabolites. Fractionations by solvent partitioning, silica vacuum flash chromatography, and reversed-phase HPLC gave a pure cytotoxic compound, designated streptokordin. Its structure was elucidated by FAB-MS, 1 H, 13 C, and 2D NMR spectroscopy. Streptokordin exhibited significant cytotoxicity against seven human cancer cell lines but showed no growth inhibition against various microorganisms including bacteria and fungi.

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“…Since the discovery of spongothymidine and spongouridine in the early 50's [1], a large number of biologically active compounds were isolated from marine sponges and their associated microorganisms [2]. The chemical diversity of sponge-derived products is remarkable and their biological activity ranges from antiinflammatory, antitumour, immuno-or neurosuppressive, antiviral, antimalarial, antibiotic to antifouling [3].…”

Section: Introductionmentioning

confidence: 99%

Secondary Metabolites From Micromonospora Sp. (G044)

Tuan¹,

Hương²,

Ngan³

et al. 2017

JST

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In the course of our screening program, the EtOAc extract of a Micromonospora sp. (strain G044) from sponge Tethya aurantium of the sea of Côtô -Thanh Lân exhibited antimicrobial activity against Enterococcus faecalis, Bacillus cereus and Candida albicans. In this paper, we reported the isolation and structural elucidation of six secondary metabolites Cyclo-(Pro-Trp) (1), Cyclo-(Pro-Met) (2), Cyclo-(Pro-Val) (4), N-acetyltryptamine (3), uridine (5), and 2-phenylacetic acid (6) from the cultures broth of Micromonospora sp. (strain G044). The structures of 1 -6 were determined by analyses of MS and 2D NMR data. All compounds were evaluated for their antimicrobial activity against a panel of clinically significant microorganisms. Compound 1 inhibited Escherichia coli with a MIC value of 128 µg/ml.

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Marine Microorganisms as a Source of New Natural Products

Cited by 175 publications

References 62 publications

Influence of microbial interactions on the susceptibility of Karenia spp. to algicidal bacteria

Influence of microbial interactions on the susceptibility of Karenia spp. to algicidal bacteria

Streptokordin, a New Cytotoxic Compound of the Methylpyridine Class from a Marine-derived Streptomyces sp. KORDI-3238

Secondary Metabolites From Micromonospora Sp. (G044)

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