Marine natural products

Carroll, Anthony Richard; Copp, Brent R.; Davis, Rohan A.; Keyzers, Robert A.; Prinsep, Michèle R.

doi:10.1039/c8np00092a

Cited by 454 publications

(378 citation statements)

References 721 publications

(522 reference statements)

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“…Marine natural products, comprising a huge variety of chemical structures and being a serendipitous source of new molecules, could play a key role on this need [26][27][28][29][30][31]. In fact, the biomedical and pharmacological potential of marine natural products is known to be still underexplored [32,33]. In a previous study of our group, aimed to find possible molecular targets for a set of marine natural products, we observed that some of them can interact with proteins involved in neurodegenerative diseases.…”

Section: Introductionmentioning

confidence: 99%

Meridianins and Lignarenone B as Potential GSK3β Inhibitors and Inductors of Structural Neuronal Plasticity

et al. 2020

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Glycogen Synthase Kinase 3 (GSK3) is an essential protein, with a relevant role in many diseases such as diabetes, cancer and neurodegenerative disorders. Particularly, the isoform GSK3β is related to pathologies such as Alzheimer's disease (AD). This enzyme constitutes a very interesting target for the discovery and/or design of new therapeutic agents against AD due to its relation to the hyperphosphorylation of the microtubule-associated protein tau (MAPT), and therefore, its contribution to neurofibrillary tangles (NFT) formation. An in silico target profiling study identified two marine molecular families, the indole alkaloids meridianins from the tunicate genus Aplidium, and lignarenones, the secondary metabolites of the shelled cephalaspidean mollusc Scaphander lignarius, as possible GSK3β inhibitors. The analysis of the surface of GSK3β, aimed to find possible binding regions, and the subsequent in silico binding studies revealed that both marine molecular families can act over the ATP and/or substrate binding regions. The predicted inhibitory potential of the molecules from these two chemical families was experimentally validated in vitro by showing ã 50% of increased Ser9 phosphorylation levels of the GSK3β protein. Furthermore, we determined that molecules from both molecular families potentiate structural neuronal plasticity in vitro. These results allow us to suggest that meridianins and lignarenone B could be used as possible therapeutic candidates for the treatment of GSK3β involved pathologies, such as AD.

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Section: Introductionmentioning

confidence: 99%

Meridianins and Lignarenone B as Potential GSK3β Inhibitors and Inductors of Structural Neuronal Plasticity

et al. 2020

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“…Marine fungi are a relevant and active component of the microbial communities that inhabit the oceans [1]. Fungi in the marine environment live as mutualists, parasites, pathogens and saprobes, and are pivotal to marine food webs because of the recycling of recalcitrant substrata [2]; besides, these widely dispersed organisms are a source of novel bioactive compounds [3].…”

Section: Introductionmentioning

confidence: 99%

News from the Sea: A New Genus and Seven New Species in the Pleosporalean Families Roussoellaceae and Thyridariaceae

et al. 2020

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Nineteen fungal strains associated with the seagrass Posidonia oceanica, with the green alga Flabellia petiolata, and the brown alga Padina pavonica were collected in the Mediterranean Sea. These strains were previously identified at the family level and hypothesised to be undescribed species. Strains were examined by deep multi-loci phylogenetic and morphological analyses. Maximum-likelihood and Bayesian phylogenies proved that Parathyridariella gen. nov. is a distinct genus in the family Thyriadriaceae. Analyses based on five genetic markers revealed seven new species: Neoroussoella lignicola sp. nov., Roussoella margidorensis sp. nov., R. mediterranea sp. nov., and R. padinae sp. nov. within the family Roussellaceae, and Parathyridaria flabelliae sp. nov., P. tyrrhenica sp. nov., and Parathyridariella dematiacea gen. nov. et sp. nov. within the family Thyridariaceae.

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“…There is a trend in the field of marine natural products to associate antifouling activity with cytotoxicity, a theory which is reinforced by the fact that a large number of marine secondary metabolites, which crafted by nature to provide marine organisms with chemical weapons to face ecological challenges such as biofouling, also show cytotoxic activity. [28] However, the reverse argument that cytotoxic terrestrial natural products may also display antifouling activity in the marine environment is not necessarily true. This is evidenced by the results of the present work, in which olivacine (1), a compound of known cytotoxic activity, [29] was a very poor antifoulant.…”

Section: Resultsmentioning

confidence: 99%

Isolation and Antimacrofouling Activity of Indole and Furoquinoline Alkaloids from ‘Guatambú’ Trees (Aspidosperma australe and Balfourodendron riedelianum)

Pérez

Diez

Valdez

et al. 2019

Chemistry & Biodiversity

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In this work, the antifouling activity of five alkaloids, isolated from trees of the Atlantic rainforest, was studied. The tested alkaloids were olivacine (1), uleine (2) and N‐methyltetrahydroellipticine (3) from Aspidosperma australe (‘yellow guatambú’) and the furoquinoline alkaloids kokusaginine (4) and flindersiamine (5) from Balfourodendron riedelianum (‘white guatambú’). All these compounds can be isolated from their natural sources in high yields in a sustainable way. The five compounds were subjected to laboratory tests (attachment test of the mussel Mytilus edulis platensis) and field trials, by incorporation into soluble matrix paints, and 45 days of exposure of the painted panels in the sea. The results show that compound 3 is a very potent antifoulant, and that compounds 4 and 5 are also very active, while compounds 1 and 2 did not show any significant antifouling activity. These results open the way for the development of environmentally friendly antifouling agents, based on abundant and easy‐to‐purify compounds that can be obtained in a sustainable way.

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Marine natural products

Abstract: A comprehensive review of 1490 new MNPs including the first naturally occurring blue zwitterionic quinoids dactylocyanines A–H is presented.

Cited by 454 publications

References 721 publications

Meridianins and Lignarenone B as Potential GSK3β Inhibitors and Inductors of Structural Neuronal Plasticity

Meridianins and Lignarenone B as Potential GSK3β Inhibitors and Inductors of Structural Neuronal Plasticity

News from the Sea: A New Genus and Seven New Species in the Pleosporalean Families Roussoellaceae and Thyridariaceae

Isolation and Antimacrofouling Activity of Indole and Furoquinoline Alkaloids from ‘Guatambú’ Trees (Aspidosperma australe and Balfourodendron riedelianum)

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