Marine natural products

Carroll, Anthony Richard; Copp, Brent R.; Davis, Rohan A.; Keyzers, Robert A.; Prinsep, Michèle R.

doi:10.1039/d0np00089b

Cited by 292 publications

(253 citation statements)

References 717 publications

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“…Interest in the oceans has grown in recent decades due to the enlargement of discovery in quantity and diversity of marine products with interesting biological/pharmacological activities [ 29 , 30 , 31 ]. Over the past fifty years, progressive improvements have been made in the exploration of new marine habitats, leading to the isolation of thousands of unique marine natural products [ 30 ] for industrial development, such as pharmaceuticals, food ingredients, cosmetics, drug delivery systems (DDS) and industrial enzymes [ 31 , 32 , 33 ]. Species such as algae, sponges and corals are in constant competition because they are at high risk of predation, so these species have developed chemical defense mechanisms based on the synthesis of toxic secondary metabolites [ 34 ].…”

Section: Marine Organisms As Sources Of Anti-glioma Compoundsmentioning

confidence: 99%

“…An extract prepared from the culture of a sea anemone-derived actinomycete Streptomyces sp. ZZ406 [ 33 ] was found to have activity in inhibiting the proliferation of glioma cells and reducing the production of lactate in glioma cells [ 37 , 38 , 39 ]. Chemical investigation of this crude active extract led to the isolation and identification of compounds 1 – 4 ( Figure 3 ) [ 40 ].…”

Section: Marine Organisms As Sources Of Anti-glioma Compoundsmentioning

confidence: 99%

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Small Molecules of Marine Origin as Potential Anti-Glioma Agents

et al. 2021

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Marine organisms are able to produce a plethora of small molecules with novel chemical structures and potent biological properties, being a fertile source for discovery of pharmacologically active compounds, already with several marine-derived agents approved as drugs. Glioma is classified by the WHO as the most common and aggressive form of tumor on CNS. Currently, Temozolomide is the only chemotherapeutic option approved by the FDA even though having some limitations. This review presents, for the first time, a comprehensive overview of marine compounds described as anti-glioma agents in the last decade. Nearly fifty compounds were compiled in this document and organized accordingly to their marine sources. Highlights on the mechanism of action and ADME properties were included. Some of these marine compounds could be promising leads for the discovery of new therapeutic alternatives for glioma treatment.

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Section: Marine Organisms As Sources Of Anti-glioma Compoundsmentioning

confidence: 99%

Section: Marine Organisms As Sources Of Anti-glioma Compoundsmentioning

confidence: 99%

Small Molecules of Marine Origin as Potential Anti-Glioma Agents

et al. 2021

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“…The function of marine compounds varies from antibacterial, antidiabetic, antiviral, antifungal and anti-inflammatory to anticancer. Many commercial marine-derived compounds have demonstrated anticancer capabilities [6,7]. According to marine pharmacology, there was a total of 14 marine-derived compounds available on the market as of October 2020, and 9 of them are used as anticancer drugs (Figure 1, Table 1) [8].…”

Section: Introductionmentioning

confidence: 99%

Development of Marine-Derived Compounds for Cancer Therapy

Zuo

Kwok

2021

Marine Drugs

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Cancer has always been a threat to human health with its high morbidity and mortality rates. Traditional therapy, including surgery, chemotherapy and radiotherapy, plays a key role in cancer treatment. However, it is not able to prevent tumor recurrence, drug resistance and treatment side effects, which makes it a very attractive challenge to search for new effective and specific anticancer drugs. Nature is a valuable source of multiple pharmaceuticals, and most of the anticancer drugs are natural products or derived from them. Marine-derived compounds, such as nucleotides, proteins, peptides and amides, have also shed light on cancer therapy, and they are receiving a fast-growing interest due to their bioactive properties. Their mechanisms contain anti-angiogenic, anti-proliferative and anti-metastasis activities; cell cycle arrest; and induction of apoptosis. This review provides an overview on the development of marine-derived compounds with anticancer properties, both their applications and mechanisms, and discovered technologies.

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“…For the past decade, the trend to discover new compounds from marine microorganisms continues to rise [1], especially from marine fungi [2,3], which accounted for 68% of the reported new marine natural products in 2019 [4]. Of particular importance is the Penicillium species, which are recognized as the richest source for the discovery of biologically important and structurally unique secondary metabolites [5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Anti-Food Allergic Compounds from Penicillium griseofulvum MCCC 3A00225, a Deep-Sea-Derived Fungus

Xing

Chen²,

Xie

et al. 2021

Marine Drugs

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Ten new (1–10) and 26 known (11–36) compounds were isolated from Penicillium griseofulvum MCCC 3A00225, a deep sea-derived fungus. The structures of the new compounds were determined by detailed analysis of the NMR and HRESIMS spectroscopic data. The absolute configurations were established by X-ray crystallography, Marfey’s method, and the ICD method. All isolates were tested for in vitro anti-food allergic bioactivities in immunoglobulin (Ig) E-mediated rat basophilic leukemia (RBL)-2H3 cells. Compound 13 significantly decreased the degranulation release with an IC50 value of 60.3 μM, compared to that of 91.6 μM of the positive control, loratadine.

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Marine natural products

Abstract: A comprehensive review of 1490 new MNPs including looekeyolides A and B, which are associated with coral black band disease.

Cited by 292 publications

References 717 publications

Small Molecules of Marine Origin as Potential Anti-Glioma Agents

Small Molecules of Marine Origin as Potential Anti-Glioma Agents

Development of Marine-Derived Compounds for Cancer Therapy

Anti-Food Allergic Compounds from Penicillium griseofulvum MCCC 3A00225, a Deep-Sea-Derived Fungus

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