Marine natural products

Abstract

A comprehensive review of 1425 new MNPs including a novel cyanobacterial cyclodepsipeptide, gatorbulin-1, that targets a 7th tubulin binding site.

Ferroptosis Inhibitory Compounds from the Deep-Sea-Derived Fungus Penicillium sp. MCCC 3A00126

“…By comparison of the NMR and MS data with those published in the literature, 34 known compounds were identified as 13 xanthones: (7R,8R)-α-diversonolic ester (3) [23,24], aspergillusone B (4) [22], 8-hydroxy-6-methyl-9-oxo-9H-xanthene-1-carboxylate (5) [25], yicathin B (6) [26], pinselin (7) [27], sydowinins A (8) and B (9) [28], huperxanthone C (10) [14], 13-O-acetylsydowinin B (11) [29], 8-(methoxycarbonyl)-1-hydroxy-9-oxo-9Hxanthene-3-carboxylic acid (12) [25], huperxanthone A (13) [14], sterigmatocystin (14) [30], 5-methoxysterigmatocystin (15) [31]; six anthraquinones: versicolorin B ( 16) [32], 8-Omethylversicolorin B (17) [33], anthraquinone aversin (18) [34], averufin (19) [35], 6-Omethylaverufin (20) [36], questin (21) [37]; five sesquiteroenoids: (S)-(+)-sydonic acid (22) [38], (S)-(+)-11-dehydrosydonic acid (23) [38], (−)-12-acetoxy-1-deoxysydonic acid (24) [39], (7S,11S)-(+)-12-acetoxysydonic acid (25) [38], (−)-(7R,10R)-iso-10-hydroxysydowic acid (26) [39]; four diphenyl ethers: diorcinol (27) [40], verticilatin (28) The 1 H and 13 C data of 2 showed the presence of two methoxyls, five methines and ten quaternary carbons, which were closely related to those of huperxanthone A (13) [14], except that the sp 2 quaternary carbon at C-7 (δ C 151.1 s) in 13 was changed as an sp 2 methine (δ C 123.1 d) in 2. By detailed analysis of its HSQC (heteronuclear single quantum correlation), 1 H-1 H COSY, HMBC, and NOESY (nuclear Overhauser effect) spectroscopic data, compound 2 was then established as 7-dehydroxyhuperxanthone A.…”

“…The oceans cover over 70% of the world's surface, with 95% of them being deeper than 1000 m. In recent years, nearly half of the new marine natural products (MNPs) have been isolated from marine microorganisms [1][2][3], especially fungi, the most diverse and abundant eukaryotes on Earth, which can be distributed in any currently known extreme environment [4]. As a region rarely explored, the deep sea is characterized by a high pressure, a low/high (such as hydrothermal mouth) temperature, a high salt concentration, the absence of light, oligotrophic conditions, a high halogen content, and so on.…”

Jellyfish Peptide as an Alternative Source of Antioxidant

“…Cnidarians, a diverse group of animals including jellyfish, sea anemones, and coral polyps, are a valuable source of bioactive substances such as terpenoids, phenolic derivatives, proteins, and peptides [ 43 ]. These compounds exhibit a wide range of biological activities, including antimicrobial, anti-inflammatory, and antitumor properties [ 44 ].…”

Phân lập, định danh vi nấm biển có hoạt tính kháng vi sinh vật từ đảo Bạch Long Vĩ, Hải Phòng

“…Trong giai đoạn 5 năm, từ 2015 đến 2015, số lượng các hợp chất mới từ vi nấm biển chiếm trên 50 % tổng số lượng các hợp chất từ biển. 4 Với bờ biển dài trên 3000km, diện tích mặt biển trên 1 triệu km 2 , Việt Nam là một trong những trung tâm đa dạng sinh học biển cao của thế giới. 5 Đảo Bạch Long Vĩ, thuộc thành phố Hải…”