Marine natural products for multi-targeted cancer treatment: A future insight

Kumar, Maushmi S.; Adki, Kaveri M.

doi:10.1016/j.biopha.2018.05.142

Cited by 51 publications

(28 citation statements)

References 110 publications

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“…A recent paper revised the literature for the selection of cancer genes for the multitargeted use of existing drugs and natural products [ 112 ]. The authors used network analysis and a search tool for retrieval of interacting genes/proteins (STRING), to study the possible interactions to show the links between antioxidants, antibiotics, anti-inflammatory and antimitotic agents and their targets, for their possible use in cancer.…”

Section: Discussionmentioning

confidence: 99%

Cognitive Impairment in Chronic Obstructive Pulmonary Disease (COPD): Possible Utility of Marine Bioactive Compounds

et al. 2018

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Chronic obstructive pulmonary disease (COPD) is characterized by long-term airflow limitation. Early-onset COPD in non-smoker subjects is ≥60 years and in the elderly is often associated with different comorbidities. Cognitive impairment is one of the most common feature in patients with COPD, and is associated with COPD severity and comorbidities. Cognitive impairment in COPD enhances the assistance requirement in different aspects of daily living, treatment adherence, and effectual self-management.This review describes various bioactive compounds of natural marine sources that modulate different targets shared by both COPD and cognitive impairment and hypothesizes a possible link between these two syndromes.

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Section: Discussionmentioning

confidence: 99%

Cognitive Impairment in Chronic Obstructive Pulmonary Disease (COPD): Possible Utility of Marine Bioactive Compounds

et al. 2018

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“…There are about 350,000 plant species on earth, which have been a major source of medicines for a long time. The Chinese began to use herbs to treat cancer, as well as cardiovascular and other incurable diseases, several thousands of years ago [9,10]. Astragalus roots which have been used in traditional Chinese medicine include those of Astragalus mongholicus and A. membranaceus [11].…”

Section: Introductionmentioning

confidence: 99%

Quantitative proteomics analysis of differentially expressed proteins induced by astragaloside IV in cervical cancer cell invasion

Xia

Cai

2020

Cell Mol Biol Lett

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Background: Cervical cancer remains the second leading cause of mortality in women in developing countries. While surgery, chemotherapy, radiotherapy, and vaccine therapy are being applied for its treatment, individually or in combination, the survival rate in advanced cervical cancer patients is still very low. Traditional Chinese medicine has been found to be effective in the treatment of cervical cancer. Astragaloside IV (AS-IV), a compound belonging to Astragalus polysaccharides, shows anticancer activity through several cell signaling pathways. However, the detailed molecular mechanism governing the anticancer activity of AS-IV remains unknown. Material and methods: In our study, we performed tumor xenograft analysis, transwell cell migration and invasion assay, Western blot analysis, and iTRAQ combination by parallel reaction monitoring (PRM) analysis to study the molecular mechanism of AS-IV in the suppression of cervical cancer cell invasion. Results: Our results showed that AS-IV suppressed cervical cancer cell invasion and induced autophagy in them, with the tumor growth curve increasing slowly. We also identified 32 proteins that were differentially expressed in the SiHa cells when treated with AS-IV, with 16 of them involved in the upregulation and 16 in the downregulation of these cells. These differentially expressed proteins, which were predominantly actinmyosin complexes, controlled cell proliferation and cell development by steroid binding and altering the composition of the cell cytoskeleton. DCP1A and TMSB4X, the two proteins regulating autophagy, increased in cervical cancer cells when treated with AS-IV. Conclusions: We conclude that AS-IV could inhibit cervical cancer invasion by inducing autophagy in cervical cancer cells. Since iTRAQ combination by PRM has been observed to be useful in identifying macromolecular target compounds, it may be considered as a novel strategy in the screening of anticancer compounds used in the treatment of cervical cancer.

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“…Extracts of several marine species were evaluated revealing biological activities attributed to substances isolated from these organisms. 1,2 Several biomolecules isolated directly from marine animals or from microbes associated to them present antimicrobial activity. 3,4 Gastropod mollusks, called nudibranchs and commonly known as sea slugs, produce toxic compounds for defense against predators.…”

Section: Introductionmentioning

confidence: 99%

Chemical Composition and Anticariogenic Activity of Tambja stegosauriformis Nudibranch

Braga

Iório²,

Póvoa³

et al. 2019

Rev. Virtual Quim.

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1457 Artigo Chemical Composition and Anticariogenic Activity of Tambja stegosauriformis Nudibranch Braga, R. R.;* Iorio, N. L. P. P; Póvoa, H. C. C.; Chianca, G. C.; Kachlicki, P.; Ożarowski, M.; Silva, V. O.; Félix, H. P.; Lopes, I. C.; Chaves, D. S. A.Resumo: Extrato do nudibrânquio da espécie Tambja stegosauriformis foi obtido por imersão em metanol, concentrados em um rotaevaporador e secos por liofilização. A identificação dos metabólitos secundários presentes nos extratos foi realizada por cromatografia líquida de alta eficiência com detector DAD, acoplada à espectrometria de massa (HPLC-DAD-MSn). Foram identificados oito alcaloides pirrólicos no extrato de T. stegosauriformis. Todos os alcaloides derivam da estrutura base com dois anéis pirrólicos interligados e presença de bromo ou não, as quais foram reportadas previamente na literatura. A atividade antibacteriana do extrato foi testada em amostras padrão de Strepcococcus mutans ATCC ("American Type Culture Collection") 25175 e Lactobacillus casei ATCC 393, determinando a Concentração Inibitória Mínima (CIM) e Concentração Bactericida Mínima (CBM) do extrato frente a essas bactérias. A atividade citotóxica das concentrações do extrato de T. stegosauriformis com atividade antibacteriana foi verificada em Artemia salina. O extrato de T. stegosauriformis apresentou atividade bacteriostática frente às espécies S. mutans (CIM = 1,175mg / mL) e L. casei (CIM = 0,5875 mg / mL). Os resultados indicam um potencial efeito anticariogênico de substâncias presentes no extrato do nudibrânquio T. stegosauriformis Palavras-chave: Nudibrânquios; produtos naturais marinhos; alcaloides pirrólicos; atividade antimicrobiana AbstractExtract from Tambja stegosauriformis nudibranch were obtained by immersion in methanol, concentrated in a rotary evaporator and dried by lyophilization. The identification of the secondary metabolites present in the extracts was performed by high performance liquid chromatography with DAD detector, coupled to mass spectrometry (HPLC-DAD-MSn). Eight pyrrole alkaloids were identified in the T. stegosauriformis extract. All alkaloids identified and reported previously in the literature are derived from the base structure of two interconnected pyrrole rings, some compounds are substituted with bromine. The antibacterial activity of the extracts was tested on Streptococcus mutans ATCC (American Type Culture Collection) 25175 and Lactobacillus casei ATCC 393 samples, determining the Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) of the extract against these bacteria. The cytotoxic activity against Artemia salina was detected in the T. stegosauriformis extract with antibacterial activity. The T. stegosauriformis extract presented bacteriostatic activity against S. mutans (MIC = 1.175mg / mL) and L. casei (MIC = 0.5875 mg / mL). The results indicate a potential anticariogenic effect of substances present in the T. stegosauriformis extract.

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Marine natural products for multi-targeted cancer treatment: A future insight

Cited by 51 publications

References 110 publications

Cognitive Impairment in Chronic Obstructive Pulmonary Disease (COPD): Possible Utility of Marine Bioactive Compounds

Cognitive Impairment in Chronic Obstructive Pulmonary Disease (COPD): Possible Utility of Marine Bioactive Compounds

Quantitative proteomics analysis of differentially expressed proteins induced by astragaloside IV in cervical cancer cell invasion

Chemical Composition and Anticariogenic Activity of Tambja stegosauriformis Nudibranch

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