Marine Natural Products, Multitarget Therapy and Repurposed Agents in Alzheimer’s Disease

Martins, Márcia; Silva, Renata; Pinto, Madalena; Sousa, Emı́lia

doi:10.3390/ph13090242

Cited by 38 publications

(31 citation statements)

References 141 publications

(254 reference statements)

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“…These compounds range from small peptides and enzymes to highly complex secondary metabolites that show bioactivities in physiological systems such as those related to movement, circulation, and respiration. The importance of marine drugs against neurodegeneration is widely recognized [ 32 , 33 ]. In fact, some natural compounds are already in preclinical studies for AD treatment [ 34 ].…”

Section: Introductionmentioning

confidence: 99%

Exploitation of Marine Molecules to Manage Alzheimer’s Disease

2021

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Neurodegenerative diseases are sociosanitary challenges of today, as a result of increased average life expectancy, with Alzheimer’s disease being one of the most prevalent. This pathology is characterized by brain impairment linked to a neurodegenerative process culminating in cognitive decline and behavioral disorders. Though the etiology of this pathology is still unknown, it is usually associated with the appearance of senile plaques and neurofibrillary tangles. The most used prophylaxis relies on anticholinesterase drugs and NMDA receptor antagonists, whose main action is to relieve symptoms and not to treat or prevent the disease. Currently, the scientific community is gathering efforts to disclose new natural compounds effective against Alzheimer’s disease and other neurodegenerative pathologies. Marine natural products have been shown to be promising candidates, and some have been proven to exert a high neuroprotection effect, constituting a large reservoir of potential drugs and nutraceutical agents. The present article attempts to describe the processes of extraction and isolation of bioactive compounds derived from sponges, algae, marine bacteria, invertebrates, crustaceans, and tunicates as drug candidates against AD, with a focus on the success of pharmacological activity in the process of finding new and effective drug compounds.

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Section: Introductionmentioning

confidence: 99%

Exploitation of Marine Molecules to Manage Alzheimer’s Disease

2021

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“…Marine natural products, developed under adverse conditions and containing unusual structures, have been a rich source for the treatment of numerous diseases including AD. A number of marine natural products, together with their derived synthetic analogs, showed good efficacy against AD [ 288 ]. Thus, marine natural products are actively sought after as neuroprotective agents for AD.…”

Section: Neuroprotective Natural Products For Admentioning

confidence: 99%

Neuroprotective Natural Products for Alzheimer’s Disease

Chen

Drew

Berney

et al. 2021

Cells

137

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Alzheimer’s disease (AD) is the number one neurovegetative disease, but its treatment options are relatively few and ineffective. In efforts to discover new strategies for AD therapy, natural products have aroused interest in the research community and in the pharmaceutical industry for their neuroprotective activity, targeting different pathological mechanisms associated with AD. A wide variety of natural products from different origins have been evaluated preclinically and clinically for their neuroprotective mechanisms in preventing and attenuating the multifactorial pathologies of AD. This review mainly focuses on the possible neuroprotective mechanisms from natural products that may be beneficial in AD treatment and the natural product mixtures or extracts from different sources that have demonstrated neuroprotective activity in preclinical and/or clinical studies. It is believed that natural product mixtures or extracts containing multiple bioactive compounds that can work additively or synergistically to exhibit multiple neuroprotective mechanisms might be an effective approach in AD drug discovery.

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“…Most investigations have been focused on their effect on MMPs during inflammatory diseases and/or cancer. Due to the relevance of MMPs (especially MMP-2 and MMP-9) in neurodegenerative diseases, marine products could also be useful for the inhibition of MMPs in AD [ 74 ].…”

Section: Natural Products From Marine Source That Modulate Mmp-2 Amentioning

confidence: 99%

Natural Marine and Terrestrial Compounds as Modulators of Matrix Metalloproteinases-2 (MMP-2) and MMP-9 in Alzheimer’s Disease

et al. 2021

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Several studies have reported neuroprotective effects by natural products. A wide range of natural compounds have been investigated, and some of these may play a beneficial role in Alzheimer’s disease (AD) progression. Matrix metalloproteinases (MMPs), a family of zinc-dependent endopeptidases, have been implicated in AD. In particular, MMP-2 and MMP-9 are able to trigger several neuroinflammatory and neurodegenerative pathways. In this review, we summarize and discuss existing literature on natural marine and terrestrial compounds, as well as their ability to modulate MMP-2 and MMP-9, and we evaluate their potential as therapeutic compounds for neurodegenerative and neuroinflammatory diseases, with a focus on Alzheimer’s disease.

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Marine Natural Products, Multitarget Therapy and Repurposed Agents in Alzheimer’s Disease

Cited by 38 publications

References 141 publications

Exploitation of Marine Molecules to Manage Alzheimer’s Disease

Exploitation of Marine Molecules to Manage Alzheimer’s Disease

Neuroprotective Natural Products for Alzheimer’s Disease

Natural Marine and Terrestrial Compounds as Modulators of Matrix Metalloproteinases-2 (MMP-2) and MMP-9 in Alzheimer’s Disease

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