Marine natural products of fungal origin

Saleem, Muhammad; Ali, Muhammad; Hussain, Shafqat; Jabbar, Abdul; Ashraf, Muhammad; Lee, Yong Sup

doi:10.1039/b607254m

Cited by 292 publications

(182 citation statements)

References 70 publications

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“…secondary metabolites [23][24][25] of the 18 000 marine natural products described, over 30% are from sponges and of the antitumor natural product patent registrations in recent years over 75% are from sponges [26,27] . Especially, the genus Aspergillus has been known to be a major contributor to the secondary metabolites of marine fungal origin, for example, four sesquiterpenoids with a unique nitrobenzyl ester from Aspergillus versicolor (A. versicolor), two modified cytotoxic tripeptides from Aspergillus sp., novel pentacyclic oxindole alkaloid from Aspergillus tamari [28] , four prenylated indole alkaloids from Aspergillus sp.…”

Section: Discussionmentioning

confidence: 99%

Analytical characterization and structure elucidation of metabolites from Aspergillus ochraceus MP2 fungi

Meenupriya

Thangaraj

2011

Asian Pacific Journal of Tropical Biomedicine

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Section: Discussionmentioning

confidence: 99%

Analytical characterization and structure elucidation of metabolites from Aspergillus ochraceus MP2 fungi

Meenupriya

Thangaraj

2011

Asian Pacific Journal of Tropical Biomedicine

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“…Similarly, varitrol obtained from the fungus Emericella variecolor Berk. & Broome showed cytotoxic activity against cancer cell lines from kidney and breast (Saleem et al, 2007).…”

Section: Introductionmentioning

confidence: 98%

Antiproliferative effect of extract from endophytic fungusCurvularia trifoliiisolated from the “Veracruz Reef System” in Mexico

Couttolenc

Espinoza

Fernández

et al. 2016

Pharmaceutical Biology

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Context: It is well known that marine fungi are an excellent source of biologically active secondary metabolites, and by 2011, it was reported that over 400 bioactive metabolites were derived from marine fungi. Objective: This study establishes the basis for future research on antiproliferative compounds of marine endophytes inhabited in the Veracruz Reef System. Materials and methods: Isolation of the 34 fungal strains was carried out by microbiological method from samples of sponges, corals, and other biological material from the Veracruz Reef System. The fungal biomass and broth were separated and extracted with a mixture of solvents MeOH:CHCl 3 . Characterization and molecular identification of the fungal strains were performed through microbiological methods and the analysis of the ITS-rDNA regions. Antiproliferative activity was tested at a dose of 250 mg/mL on human solid tumor cell lines HBL-100, HeLa, SW1573, T-47D, and WiDr by the SRB assay after 48 h-exposure to the fungal extracts. Results: The extracts from five isolates showed an antiproliferative effect against one or more of the tested cell lines (percentage growth 5 50%). The mycelial extract from the isolate LAEE 03 manifested the highest activity against the five cell lines (% PG of 17 HBL-100, 19 HeLa, 23 SW1573, -6 T-47D, and 10 WiDr) and the strain was identified as Curvularia trifolii (Kauffman) Boedijn (Pleosporaceae). Discussion and conclusion: The results obtained indicate that the extract from a marine derived C. trifolii has the antiproliferative effect, thus suggesting that this organism is a good candidate for further analysis of its metabolites. ARTICLE HISTORY

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“…1 Especially, marine-derived fungi are emerging as an attractive source for discovering new bioactive compounds. 2 Indeed, cytotoxic metabolites, such as diketopiperazine alkaloids, 3 trichodermatides 4 and carbonarones, 5 have been isolated from metabolites of marine-derived fungi. Tunicates are a rich source of unique and biologically active metabolites.…”

Section: Introductionmentioning

confidence: 99%

“…In the course of chemical screening for novel compounds from the metabolites of tunicate-derived fungi, we isolated two novel sesquiterpenoid compounds, designated as JBIR-27 (1) and -28 (2), from the culture broth of Penicillium sp. SS080624SCf1 (Figure 1).…”

Section: Introductionmentioning

confidence: 99%

New sesquiterpenes, JBIR-27 and -28, isolated from a tunicate-derived fungus, Penicillium sp. SS080624SCf1

et al. 2009

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In the course of our screening program for novel metabolites from tunicate-derived fungi, novel sesquiterpenoids, named JBIR-27 (1) and -28 (2), together with known sporogen-AO1 and phomenone, were isolated from the culture broth of Penicillium sp. SS080624SCf1. The structures of 1 and 2 were determined to be eremophilane analogs on the basis of extensive NMR and MS analyses. Sporogen-AO1, phomenone and 2 showed cytotoxicity against human cervical carcinoma cell line HeLa at IC 50 values of 8.3, 19 and 92 mM, respectively, whereas 1 was inactive at a concentration of 80 mM. Keywords: cytotoxicity; JBIR-27; JBIR-28; Penicillium sp.; terpenoid; tunicate INTRODUCTION Many bioactive substances have been isolated from marine organisms, such as marine microorganisms, phytoplankton, algae, sponges and tunicates. Moreover, marine microorganisms have been studied as the important resources for new biologically active metabolites. 1 Especially, marine-derived fungi are emerging as an attractive source for discovering new bioactive compounds. 2 Indeed, cytotoxic metabolites, such as diketopiperazine alkaloids, 3 trichodermatides 4 and carbonarones, 5 have been isolated from metabolites of marine-derived fungi. Tunicates are a rich source of unique and biologically active metabolites. 1 However, there have been few reports of compounds isolated from tunicate-derived fungi. 6,7 Therefore, we attempted to isolate fungi from a tunicate, Didemnum molle, and obtain secondary metabolites from the fungal culture broths.In the course of chemical screening for novel compounds from the metabolites of tunicate-derived fungi, we isolated two novel sesquiterpenoid compounds, designated as JBIR-27 (1) and -28 (2), from the culture broth of Penicillium sp. SS080624SCf1 (Figure 1). In addition, we also isolated known derivatives, sporogen-AO1 8 and phomenone 9 (Figure 1). This paper describes the fermentation, isolation and brief biological activity of 1, 2, sporogen-AO1 and phomenone, in addition to the taxonomy of the producing microorganism. The structure elucidation of 1 and 2 is also reported.

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Marine natural products of fungal origin

Cited by 292 publications

References 70 publications

Analytical characterization and structure elucidation of metabolites from Aspergillus ochraceus MP2 fungi

Analytical characterization and structure elucidation of metabolites from Aspergillus ochraceus MP2 fungi

Antiproliferative effect of extract from endophytic fungusCurvularia trifoliiisolated from the “Veracruz Reef System” in Mexico

New sesquiterpenes, JBIR-27 and -28, isolated from a tunicate-derived fungus, Penicillium sp. SS080624SCf1

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