Marine natural products with monoamine oxidase (MAO) inhibitory activity

Abstract

Context: Research interest in monoamine oxidase (MAO) as a promising drug target for neurodegenerative diseases has a long history. However, efforts to develop MAO inhibitors (MAOIs) from marine sources have been limited, despite the increasing number of interesting marine natural products. Objective: To review the potential of marine natural products as MAOIs source, including their activities and selectivity on MAO. Methods: Public databases such as SciFinder, MarinLit and PubMed were systematically searched from 1991 until Dec 2019. MAO and MAOI were the key terms searched combined with marine natural products and marine. Results: Six classes of marine natural products with good selectivity between the two MAO subtypes were organized with their selectivity and sources. Conclusions: This is the first review to investigate the potential of marine natural products as MAOIs source. Despite the small number of known MAOIs from marine sources, marine natural products are potential leads for the further development of MAOI drugs with novel chemical frames and good selectivity.

Marine natural products

“…Over 35 reviews featuring some aspect of marine bacteria chemistry or biology were published during 2020. Some review highlights included those describing the role of class I adenylate-forming enzymes in biosynthesis, 93 the discovery and importance of glycosylated NPs from marine microbes, 94 the potential of MNPs as monoamine oxidase inhibitors (including their activities and selectivity) and implications for neurodegenerative disease research, 95 the evolution of chemoenzymatic syntheses with a focus on meroterpenoids from Streptomyces species, 96 the importance of terpene synthases to the structural diversity of terpenoid NPs, 97 combating nematode infections using MNPs from epiphytic bacteria, 98 the biology and chemical diversity of tetramic acid derivatives from marine microbes, 99 an overview of bacterial tropone-derived NPs, 100 bacteria sourced NP contributions in the fight against mosquito-transmitted tropical diseases, 101 and an outline of the challenges and opportunities associated with the application of symbiotic microbes to the discovery of novel antibiotics. 102…”

Natural Products Inhibitors of Monoamine Oxidases—Potential New Drug Leads for Neuroprotection, Neurological Disorders, and Neuroblastoma

“…In the last three decades, the study of marine environments has been the source of great chemical diversity, and at least six isolated compounds from marine organisms have been FDA approved, with several others currently in clinical trials [187,188]. Several marine natural products have been reported with inhibitory activity toward MAO enzymes, including aplysinopsins, piloquinones, anthiactins, bromopyrroles, caulerpins, and astaxanthins, which have been compiled in a recent review [189]. As an update of the review mentioned before, two well-known phlorotannins isolated from the edible brown alga Eisenia bicyclis were found to be MAO inhibitors [190].…”

3-Phenethyl-2-phenylquinazolin-4(3H)-one isolated from marine-derived Acremonium sp. CNQ-049 as a dual- functional inhibitor of monoamine oxidases-B and butyrylcholinesterase

“…[33]. Especially, we have focused on marine natural inhibitors [34]. In this study, we isolated and identified one compound from a marine-derived Acremonium sp.…”