Marine Pharmacology in 2016–2017: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis and Antiviral Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action

Abstract

The review of the 2016–2017 marine pharmacology literature was prepared in a manner similar as the 10 prior reviews of this series. Preclinical marine pharmacology research during 2016–2017 assessed 313 marine compounds with novel pharmacology reported by a growing number of investigators from 54 countries. The peer-reviewed literature reported antibacterial, antifungal, antiprotozoal, antituberculosis, and antiviral activities for 123 marine natural products, 111 marine compounds with antidiabetic and anti-inflammatory activities as well as affecting the immune and nervous system, while in contrast 79 marine compounds displayed miscellaneous mechanisms of action which upon further investigation may contribute to several pharmacological classes. Therefore, in 2016–2017, the preclinical marine natural product pharmacology pipeline generated both novel pharmacology as well as potentially new lead compounds for the growing clinical marine pharmaceutical pipeline, and thus sustained with its contributions the global research for novel and effective therapeutic strategies for multiple disease categories.

Synthetic Approaches of Aplykurodinone‐1: A Minireview

“…Marine organisms are an important source of novel marine natural products, which usually contain unprecedented chemical skeletons and exhibit various biological activities such as antimicrobial, [1] antifungal, [2] anti-inflammatory, [3] anticancer, [4] and so on. [5] Owing to the significant biological activities and the scarcity of natural abundance, the organic community has been committed to challenging the total synthesis of marinederived natural products for a long time, leading to the invention of many new synthetic methods and strategies. As an example, the aplykurodins and aplykurodinones (Figure 1) have attracted the attention of synthetic chemists since their isolation.…”

Computational peptidology approach to the study of the chemical reactivity and bioactivity properties of Aspergillipeptide D, a cyclopentapeptide of marine origin

“…A cyclic pentapeptide named Aspergillipeptide D was isolated from the South China Sea gorgonian Melitodes squamata-derived fungus Aspergillus sp. SCSIO 41501 with moderate activity against herpes virus simplex type 1 (HSV-1) 13 . It also showed antiviral activity towards acyclovir-resistant clinical isolates of HSV-1-106 and HSV-1-153 14 – 16 .…”

A Meta-Omics Analysis Unveils the Shift in Microbial Community Structures and Metabolomics Profiles in Mangrove Sediments Treated with a Selective Actinobacterial Isolation Procedure

“…However, descriptions of the biotechnological potential of mangrove microbial communities through the use of genome mining is scarce, and little research has focused on identifying genes involved in the biosynthesis of medically and industrially relevant compounds from these sediments [ 29 , 30 , 31 , 32 ]. Among these genes, polyketide synthase (PKS) and non-ribosomal peptide synthetase (NRPS) genes are the most commonly used to assess the natural product potential of a community due to their involvement in the biosynthesis of numerous bioactive compounds [ 33 , 34 , 35 ].…”