Marine pharmacology in 2018: Marine compounds with antibacterial, antidiabetic, antifungal, anti-inflammatory, antiprotozoal, antituberculosis and antiviral activities; affecting the immune and nervous systems, and other miscellaneous mechanisms of action

Mayer, Alejandro M. S.; Pierce, Marsha L.; Howe, Katelyn; Rodrı́guez, Abimael D.; Taglialatela‐Scafati, Orazio; Nakamura, Fumiaki; Fusetani, Nobuhiro

doi:10.1016/j.phrs.2022.106391

Cited by 24 publications

(22 citation statements)

References 260 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This observation is further supported by the high antioxidant activities of phlorotannins isolated in individual form, which were comparable or even more pronounced in comparison to raw phenol-rich isolates from the thalli of brown algae [ 40 , 41 ]. Thus, it was logical to assume that pronounced antioxidant activities of F. vesiculosus and P. canaliculata extracts are promising in the therapy of human diseases characterized by the high impact of oxidative stress on their pathogenesis [ 42 , 43 , 44 , 45 ].…”

Section: Discussionmentioning

confidence: 99%

First Insight into the Neuroprotective and Antibacterial Effects of Phlorotannins Isolated from the Cell Walls of Brown Algae Fucus vesiculosus and Pelvetia canaliculata

et al. 2023

View full text Add to dashboard Cite

Phaeophyceae (brown algae) essentially contribute to biotopes of cold and temperate seas. Their thalli are rich in biologically active natural products, which are strongly and universally dominated with phlorotannins—polyphenols of complex and diverse structure based on multiple differently arranged phloroglucinol units and well known as strong antioxidants with a broad spectrum of biological activities. In the algal cells, phlorotannins can either accumulate in the cytoplasm or can be secreted into the cell wall (CW). The biological activities of extractable intracellular phlorotannins have been comprehensively characterized, whereas the properties of the CW-bound polyphenol fraction are still mostly unknown. Recently, we identified dibenzodioxin bonding as the principal structural feature of the CW-bound phlorotannins in fucoid algae, whereas soluble intracellular phlorotannins rely on aryl and ether bonds. However, profiles of biological activity associated with these structural differences are still unknown. Therefore, to the best of our knowledge, for the first time we address the antioxidant, cytotoxic, neuroprotective, and antibacterial properties of the CW-bound phlorotannin fractions isolated from two representatives of the order Fucales—Fucus vesiculosus and Pelvetia canaliculata. The CW-bound phlorotannins appeared to be softer antioxidants, stronger antibacterial agents and were featured with essentially less cytotoxicity in comparison to the intracellular fraction. However, the neuroprotective effects of both sub-cellular phlorotannin fractions of F. vesiculosus and P. canaliculata were similar. Thus, due to their lower cytotoxicity, CW-bound phlorotannins can be considered as promising antioxidants and neuroprotectors.

show abstract

Section: Discussionmentioning

confidence: 99%

First Insight into the Neuroprotective and Antibacterial Effects of Phlorotannins Isolated from the Cell Walls of Brown Algae Fucus vesiculosus and Pelvetia canaliculata

et al. 2023

View full text Add to dashboard Cite

show abstract

“…This observation is further supported by the high antioxidant activities of phlorotannins isolated in individual form, which were comparable or even more pronounced in comparison to raw phenolrich isolates from the thalli of brown algae [40,41]. Thus, it was logical to assume that pronounced antioxidant activities of F. vesiculosus and P. canaliculata extracts are promising in therapy of human diseases characterized with high impact of oxidative stress on their pathogenesis [42][43][44][45].…”

Section: Discussionmentioning

confidence: 86%

Neuroprotective and antibacterial effects of phlorotannins isolated from the cell walls of brown algae Fucus vesiculosus and Pelvetia canaliculata

Meshalkina

Цветкова

Orlova

et al. 2022

Preprint

View full text Add to dashboard Cite

The Phaeophyceae (brown algae) essentially contribute to biotopes of cold and temperate seas. Their thalli are rich in biologically active natural products which are strongly and universally dominated with phlorotannins – polyphenols of complex and diverse structure based on multiple differently arranged phloroglucinol units. These electron-rich compounds are strong antioxidants with antimicrobial, anti-inflammatory and neuroprotective activities. In the algal cells phlorotannins can either accumulate in cytoplasm or can be secreted into the cell wall (CW) with subsequent covalent binding to the alginate network. The biological activities of easily extractable intracellular phlorotannins were comprehensively characterized, whereas the properties of the CW-bound polyphenol fraction are still mostly unknown. Recently, we identified dibenzodioxin bonding as the principal structural feature of the CW-bound phlorotannins of fucoid algae, whereas soluble intracellular phlorotannins relied on aryl- and ether bonds. However, profiles of biological activity associated with these structural differences are still unknown. Therefore, here, to the best of our knowledge, for the first time, we address the antioxidant, cytotoxic, neuroprotective, and antibacterial properties of the CW-bound phlorotannin fractions isolated from two representatives of the order Fucales - Fucus vesiculosus and Pelvetia canaliculata. The CW-bound phlorotannins appeared to be softer antioxidants, stronger antibacterial agents and were featured with essentially less cytotoxicity in comparison to the intracellular fraction. However, the neuroprotective effects of both sub-cellular phlorotannin fractions of F. vesiculosus and P. canaliculata were essentially similar. Thus, due to their lower cytotoxicity, CW-bound phlorotannins can be considered as promising antioxidants and neuroprotectors.

show abstract

“…In particular, brown seaweeds are classi ed and evidenced for abundant secondary metabolites with excellent therapeutic potential 3 . The secondary metabolites from seaweeds are characterized as glycosides, sugars, peptides, terpenoids, polyketides, alkaloids, and steroids and were found to possess several therapeutic activities such as antioxidant, antitumor, anticoagulant, antidiabetic, and antiin ammatory properties 4,5,6 . Since, the secondary metabolites were evaluated for various bioactivities, there is no effective drug molecule has been found to halt or reverse the neurodegeneration in the brain.…”

Section: Introductionmentioning

confidence: 99%

Amelioration of oxidative stress induced neurochemical degradation and neurodegeneration: A neuroprotective natural glycoside from Turbinaria ornata

Lingappa

Ganapathy

Hemalatha

et al. 2022

Preprint

View full text Add to dashboard Cite

Seaweed’s are abundant reservoir for biologically active molecules with antioxidant, anti-inflammatory, antiapoptotic and protease inhibition activities. The multifunctional properties of glycosides from seaweed could be utilized to treat diverse pathologic aetiologies of various human diseases. There are many pathological implications, of which the neurodegeneration is a relentless neurological disorder, which is characterized by progressive atrophy in the nervous system. Reports on the use of bioactive molecules from the seaweeds for the neurodegeneration is least explored. The present study characterizes the therapeutically important active molecule from the methanolic extracts of Turbinaria ornata and was used to assess the neurological progressive atrophy ability of the same. Two major fractions, MWTO (Methanol: Water (1:1) fraction from T. ornata) and MTO (Methanol fraction from T. ornata) were purified and eluted by column chromatography and the functional group was found to be glycoside’s. The MWTO fraction showed promising antioxidant, anti-proteolytic, anti-haemolytic and anticoagulant properties compared to the MTO fraction. The acetylcholine and butyrylcholine esterase inhibition activity of the MWTO were observed as 92.21% and 54.45% at 250µg, respectively. The in-vitro study revealed that MWTO could prevent cytotoxicity and ROS formation in SH-SY5Y cells and significantly enhance the cell proliferation (50%), thus could halt the progressive atrophy of the disease in the neurons. Later, MWTO was subjected to chemical characterization by UHPLC-ESI/MS and predicted the aglycone molecule of triterpenoid Oleanolic acid with the deprotonated molecular mass of 455m/z. Therefore, the therapeutically active MWTO could be used to combat neurodegeneration and related diseases.

show abstract

Marine pharmacology in 2018: Marine compounds with antibacterial, antidiabetic, antifungal, anti-inflammatory, antiprotozoal, antituberculosis and antiviral activities; affecting the immune and nervous systems, and other miscellaneous mechanisms of action

Cited by 24 publications

References 260 publications

First Insight into the Neuroprotective and Antibacterial Effects of Phlorotannins Isolated from the Cell Walls of Brown Algae Fucus vesiculosus and Pelvetia canaliculata

First Insight into the Neuroprotective and Antibacterial Effects of Phlorotannins Isolated from the Cell Walls of Brown Algae Fucus vesiculosus and Pelvetia canaliculata

Neuroprotective and antibacterial effects of phlorotannins isolated from the cell walls of brown algae Fucus vesiculosus and Pelvetia canaliculata

Amelioration of oxidative stress induced neurochemical degradation and neurodegeneration: A neuroprotective natural glycoside from Turbinaria ornata

Contact Info

Product

Resources

About