Marine pigmented bacteria: A prospective source of antibacterial compounds

Ramesh, Chatragadda; Vinithkumar, Nambali Valsalan; Kirubagaran, Ramalingam

doi:10.4103/jnsbm.jnsbm_201_18

Cited by 49 publications

(46 citation statements)

References 7 publications

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“…Regardless of their role in the environment, they offer several benefits to humanity; one such benefit is pigment production by several microbes, of which deserved importance is being highlighted in recent times, and there are still more untapped sources to explore many unknown pigmented compounds [2]. The importance of microbial pigments has been emphasized in different applications, such as cosmetics, food, pharmaceuticals, and textiles, and these compounds are also well-known to exhibit cytotoxic, antioxidant, antimicrobial, antimalarial, anticancer, antitumor, and antifouling activities [3,4,5,6,7].…”

Section: Introductionmentioning

confidence: 99%

Multifaceted Applications of Microbial Pigments: Current Knowledge, Challenges and Future Directions for Public Health Implications

et al. 2019

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Microbial oddities such as versatile pigments are gaining more attention in current research due to their widely perceived applications as natural food colorants, textiles, antimicrobial activities, and cytotoxic activities. This indicates that the future generation will depend on microbial pigments over synthetic colorants for sustainable livelihood. Although several reviews have detailed the comprehensive applications of microbial pigments extensively, knowledge on several aspects of pigmented microbes is apparently missing and not properly reviewed anywhere. Thus, this review has been made to provide overall knowledge on biodiversity, distribution, pathogenicity, and ecological and industrial applications of microbial pigments as well as their challenges and future directions for food, industrial, and biomedical applications. Meticulously, this compendious review treatise on the pigments from bacteria, fungi, yeasts, and microalgae includes reports from the 1970s to 2018. A total of 261 pigment compounds produced by about 500 different microbial species are included, and their bioactive nature is described.

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Section: Introductionmentioning

confidence: 99%

Multifaceted Applications of Microbial Pigments: Current Knowledge, Challenges and Future Directions for Public Health Implications

et al. 2019

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“…MIC and MBC analysis of both pigment extracts obtained from strain S2.1 and BSE6.1 displayed complete inhibition of S. aureus at the ranges between 150 to 400 µg/mL concentrations, respectively (Figure 8). Prodigiosin extracts (with concentrations of 50 to 400 µg/mL) obtained from various marine bacteria are reportedly displayed effective antibacterial against different pathogenic bacteria [5]. The inhibition zones (20 to 28 mm) observed in this study are greater than the previous studies [5,24].…”

Section: Antibacterial Activity Of the Pigmentmentioning

confidence: 44%

“…Prodigiosin extracts (with concentrations of 50 to 400 µg/mL) obtained from various marine bacteria are reportedly displayed effective antibacterial against different pathogenic bacteria [5]. The inhibition zones (20 to 28 mm) observed in this study are greater than the previous studies [5,24]. Thus, strains S2.1 and BSE6.1 are offering great demand for drug development.…”

Section: Antibacterial Activity Of the Pigmentmentioning

confidence: 52%

Applications of Prodigiosin Extracted from Marine Red Pigmented Bacteria Zooshikella sp. and Actinomycete Streptomyces sp.

et al. 2020

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This study is aimed to determine the distribution, diversity and bioprospecting aspects of marine pigmented bacteria (MPB) isolated from pristine Andaman Islands, India. A total of 180 samples including seawater, sediment, marine plants, invertebrates, and vertebrates were collected and investigated for isolating pigmented bacteria. Results revealed that sediment, invertebrates, and seawater samples were colonized with a greater number of pigmented bacteria pertains to 27.9 × 103 CFU/mL, 24.1 × 103 CFU/mL and 6.7 × 103 CFU/mL respectively. Orange (21.6 × 103 CFU/mL) and red (8.0 × 103 CFU/mL) MPB were predominant than other pigmented bacteria. Fourteen potential MPB were selected based on their intense pigmentation and tested for bioactive nature and food colorant applications. Out of 14, two red pigmented strains BSE6.1 & S2.1 displayed potential multifaceted applications, such as antibacterial, antioxidant, food colorant, and staining properties. Brown pigmented strains CO8 and yellow pigmented strain SQ2.3 have displayed staining properties. Chemical characterization of red pigment using TLC, HP-LC, GC-MS, FT-IR and 1H-NMR analysis revealed prodigiosin as a main chemical constituent. Pure form of prodigiosin compound fractions obtained from both the strains displayed effective antibacterial activity against different human pathogens. MIC and MBC assays revealed that S2.1 requires 300 µg and 150 µg, respectively, and BSE6.1 require 400 µg concentrations of pigment compound for complete inhibition of S. aureus subsp. aureus. On the basis of 16S rRNA sequence analysis, strains S2.1 and BSE6.1 were identified as Zooshikella sp. and Streptomyces sp. and assigned under the GenBank accession numbers: MK680108 and MK951781 respectively.

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“…Marinoquinoline A is an anticancer alkaloid produced by Catalinimonas alkaloidigena, a marine bacterium [36] along with 13 other alkaloid metabolites. Pseudoalteromonas tunicata and P. citrea are two marine bacteria that secrete a yellow-pigmented alkaloid that belongs to a group called tambjamines, and this showed anti-tumor activity along with antimicrobial, antifungal, and antimalarial activity [37,38]. Calothrixins A and B are alkaloids containing a phenanthridine moiety that are isolated from Calothrix sp.…”

Section: Alkaloidsmentioning

confidence: 99%

“…Palmyramide A has shown moderate cytotoxic effects on human lung cell line H-460 [116]. Pitipeptolides A (40), and B (41) ( Figure 6), cyclic depsipeptides isolated from a marine cyanobacterium Lyngbya majuscule, were Obyanamide (37) (Figure 6), a cyclic depsipeptide isolated from lyngbya confervoides, has demonstrated significant cytotoxicity to the kB and LoVo cells [114]. Palau'amide (38) (Figure 6) is a cyclical depsipeptide isolated from the same marine cyanobacteria Lyngbya sp., which has shown significant cytotoxicity to kB cells [115].…”

Section: Peptidesmentioning

confidence: 99%

Marine Cyanobacteria and Microalgae Metabolites—A Rich Source of Potential Anticancer Drugs

Mondal¹,

Bose

Banerjee³

et al. 2020

Marine Drugs

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Cancer is at present one of the utmost deadly diseases worldwide. Past efforts in cancer research have focused on natural medicinal products. Over the past decades, a great deal of initiatives was invested towards isolating and identifying new marine metabolites via pharmaceutical companies, and research institutions in general. Secondary marine metabolites are looked at as a favorable source of potentially new pharmaceutically active compounds, having a vast structural diversity and diverse biological activities; therefore, this is an astonishing source of potentially new anticancer therapy. This review contains an extensive critical discussion on the potential of marine microbial compounds and marine microalgae metabolites as anticancer drugs, highlighting their chemical structure and exploring the underlying mechanisms of action. Current limitation, challenges, and future research pathways were also presented.

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Marine pigmented bacteria: A prospective source of antibacterial compounds

Cited by 49 publications

References 7 publications

Multifaceted Applications of Microbial Pigments: Current Knowledge, Challenges and Future Directions for Public Health Implications

Multifaceted Applications of Microbial Pigments: Current Knowledge, Challenges and Future Directions for Public Health Implications

Applications of Prodigiosin Extracted from Marine Red Pigmented Bacteria Zooshikella sp. and Actinomycete Streptomyces sp.

Marine Cyanobacteria and Microalgae Metabolites—A Rich Source of Potential Anticancer Drugs

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