The Bird's Head Seascape (BHS), Papua, Indonesia is located within the epicenter of global marine biodiversity and has been the focus of recent conservation efforts to protect marine resources. Here, we provide an overview of Marine Protected Areas (MPAs) progress in the BHS over the past decade, including establishment history, changes in management effectiveness and ecosystem health, as well as examining trends in tourism growth. While generally viewed as a conservation success story, we reflect on both successes and challenges in the BHS, identifying where we need to continue to improve and adapt in response to rapid economic and environmental change. As of 2020, BHS MPAs cover 5.1 million ha across 23 MPAs. As expected, management effectiveness is steadily increasing in BHS MPAs-although newer MPAs face Purwanto and Dominic A. Andradi-Brown should be considered joint first authors.